Research group: Virulence Nano-Macromolecular MachinosomeGroup leader

Phone: +33 6 01 27 71 18

Room: BM208

Research Interests

I’m a molecular microbiologist, using different approaches including structural biology to study the intimacy of bacterial virulence factors and their implication in human health.

​I have been working for 20 years in the field of bacterial secretion systems. I love to decipher their molecular architecture, how all the pieces are put together to make these beautiful nanomachines work efficiently. My ultimate goal is to transform the molecular knowledge derived from our research to find ways to block these virulence factors by developing “grains of sand” to block the nanomachine engine. Theses molecules or peptides are promising therapeutic options to fight bacterial infections in the context of antibiotic resistance.

For more details, please visit us at VN2M Team

Publications

2020

2020
Structural basis for loading and inhibition of a bacterial T6 SS phospholipase effector by the VgrG spike

Nicolas Flaugnatti, Chiara Rapisarda, Martial Rey, Solène Beauvois, Viet Anh Nguyen, Stéphane Canaan, Eric Durand, Julia Chamot‐rooke, E. Cascales, Rémi Fronzes, Laure Journet

EMBO Journal 39:e104129 (2020)10.15252/embj.2019104129

2019

2019
Structure and Activity of the Type VI Secretion System

Yassine Cherrak, Nicolas Flaugnatti, Eric Durand, Laure Journet, E. Cascales

Microbiology Spectrum 7 (2019)10.1128/microbiolspec.PSIB-0031-2019

2019
Impact of high-fat diet and vitamin D3 supplementation on aortic stenosis establishment in waved-2 epidermal growth factor receptor mutant mice

Bérénice Colleville, Nicolas Perzo, Guillaume Avinée, Anaïs Dumesnil, Frederic Ziegler, Paul Billoir, Hélène Eltchaninoff, Vincent Richard, Eric Durand

Chinese Journal of Integrative Medicine 17:107-114 (2019)10.1016/j.joim.2019.01.010

2019
Development of a Risk Score Based on Aortic Calcification to Predict 1-Year Mortality After Transcatheter Aortic Valve Replacement

Pierre Lantelme, Hélène Eltchaninoff, Muriel Rabilloud, Geraud Souteyrand, Marion Dupré, Marco Spaziano, Clément Becle, Benjamin Riche, Eric Durand, Erik Bouvier, Jean-Nicolas Dacher, Pierre Courand, Lucie Cassagnes, Eduardo Dávila Serrano, Pascal Motreff, Loic Boussel, Thierry Lefèvre, Brahim Harbaoui

JACC: Cardiovascular Imaging 12:123-132 (2019)10.1016/j.jcmg.2018.03.018

2019
In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex

Chiara Rapisarda, Yassine Cherrak, Romain Kooger, Victoria Schmidt, Riccardo Pellarin, Laureen Logger, E. Cascales, Martin Pilhofer, Eric Durand, Rémi Fronzes

EMBO Journal 38 (2019)10.15252/embj.2018100886

2018

2018
Biogenesis and structure of a type VI secretion baseplate

Yassine Cherrak, Chiara Rapisarda, Riccardo Pellarin, Guillaume Bouvier, Benjamin Bardiaux, Fabrice Allain, Christian Malosse, Martial Rey, Julia Chamot-Rooke, E. Cascales, Rémi Fronzes, Eric Durand

Nature Microbiology 3:1404-1416 (2018)10.1038/s41564-018-0260-1

2018
Coherent beam combining of seven fiber chirped-pulse amplifiers using an interferometric phase measurement

Anke Heilmann, Jérémy Le Dortz, Louis Daniault, Ihsan Fsaifes, Séverine Bellanger, Jérôme Bourderionnet, Christian Larat, Eric Lallier, Marie Antier, Eric Durand, Christophe Simon-Boisson, Arnaud Brignon, Jean-Christophe Chanteloup

Optics Express 26:31542 (2018)10.1364/OE.26.031542

2018
Towards a complete structural deciphering of Type VI secretion system

van Son Nguyen, Badreddine Douzi, Eric Durand, Alain Roussel, E. Cascales, Christian Cambillau

Current Opinion in Structural Biology 49:77-84 (2018)10.1016/j.sbi.2018.01.007

2018
Tryptophan-mediated Dimerization of the TssL Transmembrane Anchor Is Required for Type VI Secretion System Activity

Abdelrahim Zoued, Jean-Pierre Duneau, Eric Durand, Alexandre España, Laure Journet, Françoise Guerlesquin, E. Cascales

Journal of Molecular Biology 430:987-1003 (2018)10.1016/j.jmb.2018.02.008

2017

2017
Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex

van Son Nguyen, Laureen Logger, Silvia Spinelli, Pierre Legrand, Thi Thanh Huyen Pham, Thi Trang Nhung Trinh, Yassine Cherrak, Abdelrahim Zoued, Aline Desmyter, Eric Durand, Alain Roussel, Christine Kellenberger, E. Cascales, Christian Cambillau

Nature Microbiology 2:17103 (2017)10.1038/nmicrobiol.2017.103

2017
TssA: The cap protein of the Type VI secretion system tail

Abdelrahim Zoued, Eric Durand, Yoann Santin, Laure Journet, Alain Roussel, Christian Cambillau, E. Cascales

BioEssays 39 (2017)10.1002/bies.201600262

2016

2016
Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component

Laureen Logger, Marie-Stéphanie Aschtgen, Marie Guérin, E. Cascales, Eric Durand

Journal of Molecular Biology 428:4424-4437 (2016)10.1016/j.jmb.2016.08.032

2016
Association Between Transcatheter Aortic Valve Replacement and Subsequent Infective Endocarditis and In-Hospital Death

Ander Regueiro, Axel Linke, Azeem Latib, Nikolaj Ihlemann, Marina Urena, Thomas Walther, Oliver Husser, Howard C. Herrmann, Luis Nombela-Franco, Asim N. Cheema, Hervé Le Breton, Stefan Stortecky, Samir Kapadia, Antonio L. Bartorelli, Jan Malte Sinning, Ignacio Amat-Santos, Antonio Munoz-Garcia, Stamatios Lerakis, Enrique Gutierrez-Ibanes, Mohamed Abdel-Wahab, Didier Tchetche, Luca Testa, Hélène Eltchaninoff, Ugolino Livi, Juan Carlos Castillo, Hasan Jilaihawi, John G. Webb, Marco Barbanti, Susheel Kodali, Jr. Brito, Henrique B. Ribeiro, Antonio Miceli, Claudia Fiorina, Guglielmo Mario Actis Dato, Francesco Rosato, Vicenc Serra, Jean-Bernard Masson, Harindra C. Wijeysundera, Jose A. Mangione, Maria-Cristina Ferreira, Valter C. Lima, Luiz A. Carvalho, Alexandre Abizaid, Marcos A. Marino, Vinicius Esteves, Julio C. M. Andrea, Francesco Giannini, David Messika-Zeitoun, Dominique Himbert, Won-Keun Kim, Costanza Pellegrini, Vincent Auffret, Fabian Nietlispach, Thomas Pilgrim, Eric Durand, John Lisko, Raj R. Makkar, Pedro A. Lemos, Martin B. Leon, Rishi Puri, Alberto San Roman, Alec Vahanian, Lars Sondergaard, Norman Mangner, Josep Rodes-Cabau

Journal of the American Medical Association 316:1083-1092 (2016)10.1001/jama.2016.12347

2016
Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

Thibault Sana, Nicolas Flaugnatti, Kyler Lugo, Lilian Lam, Amanda Jacobson, Virginie Baylot, Eric Durand, Laure Journet, E. Cascales, Denise Monack

Proceedings of the National Academy of Sciences of the United States of America 113:E5044-E5051 (2016)10.1073/pnas.1608858113

2016
Priming and polymerization of a bacterial contractile tail structure. 1" 2" 17

Abdelrahim Zoued, Eric Durand, Yannick Brunet, Silvia Spinelli, Badreddine Douzi, Mathilde Guzzo, Nicolas Flaugnatti, Pierre Legrand, Laure Journet, Rémi Fronzes, Tam Mignot, Christian Cambillau, E. Cascales

Nature 531:59-63 (2016)10.1038/nature17182

2016
Structure–Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes

Abdelrahim Zoued, Chloé Cassaro, Eric Durand, Badreddine Douzi, Alexandre España, Christian Cambillau, Laure Journet, E. Cascales

Journal of Molecular Biology 428:4413-4423 (2016)10.1016/j.jmb.2016.08.030

2015

2015
Biogenesis and structure of a Type VI secretion membrane core complex

Eric Durand, van Son Nguyen, Abdelrahim Zoued, Laureen Logger, Gerard Pehau-Arnaudet, Marie-Stéphanie Aschtgen, Silvia Spinelli, Aline Desmyter, Benjamin Bardiaux, Annick Dujeancourt, Alain Roussel, Christian Cambillau, E. Cascales, Rémi Fronzes

Nature 523:555-560 (2015)10.1038/nature14667

2015
Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody

van Son Nguyen, Laureen Logger, Silvia Spinelli, Aline Desmyter, Thi Thu Hang Le, Christine Kellenberger, Badreddine Douzi, Eric Durand, Alain Roussel, E. Cascales, Christian Cambillau

PLoS ONE 10:1-14 (2015)

2014

2014
Long-term outcome in early survivors of cardiogenic shock at the acute stage of myocardial infarction: a landmark analysis from the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) Registry

Nadia Aissaoui, Etienne Puymirat, Tabassome Simon, Eric Bonnefoy-Cudraz, Denis Angoulvant, Francois Schiele, Hakim Benamer, Philippe Quandalle, Fabrice Prunier, Eric Durand, Laurence Berard, Didier Blanchard, Nicolas Danchin

Critical Care 18:516 (2014)10.1186/s13054-014-0516-y

2014
Long-term outcome in early survivors of cardiogenic shock at the acute stage of myocardial infarction: a landmark analysis from the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) Registry.

Nadia Aissaoui, Etienne Puymirat, Tabassome Simon, Eric Bonnefoy-Cudraz, Denis Angoulvant, Francois Schiele, Hakim Benamer, Philippe Quandalle, Fabrice Prunier, Eric Durand, Laurence Berard, Didier Blanchard, Nicolas Danchin

Critical Care 18:516 (2014)10.1186/PREACCEPT-1446656168127984

2014
Crystal Structure and Self-Interaction of the Type VI Secretion Tail-Tube Protein from Enteroaggregative Escherichia coli

Badreddine Douzi, Silvia Spinelli, Stéphanie Blangy, Alain Roussel, Eric Durand, Yannick Brunet, E. Cascales, Christian Cambillau

PLoS ONE 9:e86918 (2014)10.1371/journal.pone.0086918

2014
Head-to-Head Comparison of a Drug-Free Early Programmed Dismantling Polylactic Acid Bioresorbable Scaffold and a Metallic Stent in the Porcine Coronary Artery

Eric Durand, Tahmer Sharkawi, Guy Leclerc, Marine Raveleau, Machiel van der Leest, Michel Vert, Antoine Lafont

Circulation: Cardiovascular Interventions 7:70-79 (2014)10.1161/CIRCINTERVENTIONS.113.000738

2014
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.

Eric Durand, Christian Cambillau, E. Cascales, Laure Journet

Trends Microbiol. 22:498-507 (2014)10.1016/j.tim.2014.06.004

2014
Architecture and assembly of the Type VI secretion system.

Abdelrahim Zoued, Yannick R Brunet, Eric Durand, Marie-Stéphanie Aschtgen, Laureen Logger, Badreddine Douzi, Laure Journet, Christian Cambillau, E. Cascales

Biochim. Biophys. Acta 1843:1664-73 (2014)10.1016/j.bbamcr.2014.03.018

2013

2013
2013
TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System

Abdelrahim Zoued, Eric Durand, Cecilia Bebeacua, Yannick Brunet, Badreddine Douzi, Christian Cambillau, E. Cascales, Laure Journet

Journal of Biological Chemistry 288:27031-27041 (2013)10.1074/jbc.M113.499772

2012

2012
Adjusting a polymer formulation for an optimal bioresorbable stent: a 6-month follow-up study

Eric Durand, Mathilde Lemitre, Ludovic Couty, Tahmer Sharkawi, Camille Brasselet, Michel Vert, Antoine Lafont

EuroIntervention 8:242-249 (2012)10.4244/EIJV8I2A38

2012
Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system.

Eric Durand, Estelle Derrez, Gilles Audoly, Silvia Spinelli, Miguel Ortiz-Lombardia, Didier Raoult, E. Cascales, Christian Cambillau

Journal of Biological Chemistry 287:38190-9 (2012)10.1074/jbc.M112.390153

2012
Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems.

Eric Durand, Abdelrahim Zoued, Silvia Spinelli, Paul J H Watson, Marie-Stéphanie Aschtgen, Laure Journet, Christian Cambillau, E. Cascales

Journal of Biological Chemistry 287:14157-68 (2012)10.1074/jbc.M111.338731

2012
Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: results of the erythropoietin in myocardial infarction trial.

Fabrice Prunier, Loïc Bière, Martine Gilard, Jacques Boschat, Frédéric Mouquet, Jean-Jacques Bauchart, Bernard Charbonnier, Olivier Genée, Patrice Guérin, Karine Warin-Fresse, Eric Durand, Antoine Lafont, Luc Christiaens, Wissam Abi-Khalil, Stéphane Delépine, Thomas Benard, Alain Furber

American Heart Journal 163:200-7.e1 (2012)10.1016/j.ahj.2011.11.005

2011

2011
Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar

Catarina Felisberto-Rodrigues, Eric Durand, Marie-Stéphanie Aschtgen, Stephanie Blangy, Miguel Ortiz-Lombardia, Badreddine Douzi, Christian Cambillau, E. Cascales

PLoS Pathogens 7:e1002386 (2011)10.1371/journal.ppat.1002386

2011
Structure of the minor pseudopilin XcpW from the Pseudomonas aeruginosa type II secretion system.

Laura P Franz, Badreddine Douzi, Eric Durand, David H Dyer, Romé Voulhoux, Katrina T Forest

Acta Crystallogr. D Biol. Crystallogr. 67:124-30 (2011)10.1107/S0907444910051954

2010

2010
Probabilistic analysis of a genealogical model of animal group patterns.

Eric Durand, Olivier François

Journal of Mathematical Biology 60:451-68 (2010)10.1007/s00285-009-0270-y

2010
Spatially explicit Bayesian clustering models in population genetics.

Olivier François, Eric Durand

Molecular Ecology Resources 10:773-84 (2010)10.1111/j.1755-0998.2010.02868.x

2009

2009
Comment on 'On the inference of spatial structure from population genetics data'.

Eric Durand, Chibiao Chen, Olivier François

Bioinformatics 25:1802-4; author reply 1805-6 (2009)10.1093/bioinformatics/btp337

2009
Le site perché moustérien de la montagne d'Andance (Saint-Bauzile, Ardèche), première approche archéologique

Eric Durand, Odile Franc, Jean-François Pasty, Philippe Alix, Marie-Hélène Moncel

Ardèche archéologie 26:15-21 (2009)

2007

2007
Bayesian clustering algorithms ascertaining spatial population structure: A new computer program and a comparison study

Chibiao Chen, Eric Durand, Florence Forbes, Olivier Francois

Molecular Ecology Notes 7:747-756 (2007)10.1111/j.1471-8286.2007.01769.x

2007
Prediction of group patterns in social mammals based on a coalescent model.

Eric Durand, Michael G B Blum, Olivier François

Journal of Theoretical Biology 249:262-70 (2007)10.1016/j.jtbi.2007.07.012

2006

2006
apTreeshape: statistical analysis of phylogenetic tree shape.

Nicolas Bortolussi, Eric Durand, Michael Blum, Olivier François

Bioinformatics 22:363-4 (2006)10.1093/bioinformatics/bti798

2005

2005
Collagen and elastin cross-linking: a mechanism of constrictive remodeling after arterial injury.

Camille Brasselet, Eric Durand, Faouzi Addad, Ayman Al Haj Zen, Mirjam Smeets, Dominique Laurent-Maquin, Sylvie Bouthors, Georges Bellon, Dominique de Kleijn, Gaston Godeau, Roselyne Garnotel, Bruno Gogly, Antoine Lafont

AJP - Heart and Circulatory Physiology 289:H2228-33 (2005)10.1152/ajpheart.00410.2005

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