2026
2026
Structure and Function of the Type IX Secretion System for Protein Secretion and Cellular Motility
Yaëlle Aouizerate, Thierry Doan, Eric Cascales
Annual Review of Microbiology (2026)10.1146/annurev-micro-042324-112641
2026
Reevaluation of mycobacterial Phosphatidyl-myo-Inositol Mannosides (PIMs) as Toll-Like Receptor 2 (TLR2) Agonists
Sonia Belkai, Christophe Carrat, Emilie Layre, Diane Cala-de Paepe, Alain Vercellone, Landry Blanc, Charlotte Dessaux, Cyrine Chanchabi, Alexandre Stella, Odile Burlet-Schiltz, Stéphane Canaan, Isabelle Vergne, Jérôme Nigou, Martine Gilleron
Journal of Lipid Research 101098 (2026)10.1016/j.jlr.2026.101098
2026
Elliptical β ‐barrel deformation underlies gating in VDAC1
L. Bergdoll, M. Elgeti, J. Belyaeva, A. Zlobin, Jean-Pierre Duneau, W. Hubbell, J. Abramson
Protein Science 35 (2026)10.1002/pro.70677
2026
Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes
Lola Bosc, Thomas Sécher, Genevieve Ball, Deborah Le Pennec, Mathilde Tribout, Moly Ba, Yingjie Bai, Laurent Ouerdane, Pascal Arnoux, Yann Denis, Xiaoguang Lei, Christophe Bordi, Nathalie Heuzé-Vourc’h, Susanne Häussler, Nicolas Oswaldo Gomez, Romé Voulhoux
Infection and Immunity 94:e00453-25 (2026)10.1128/iai.00453-25
2026
Quick and Cheap: Optimized Purification and Concentration of Bacteriophages Produced in Rich Culture Media
Amel Chaïb, Laura Schmitt, Adeline Goulet, Claire Le Marrec
Bio-protocol 16:e5608 (2026)10.21769/bioprotoc.5608
2026
Fast-growing intracellular Mycobacterium tuberculosis populations evade antibiotic treatment
Nathan J Day, Baptiste Pradel, Chak Hon Luk, Pierre Santucci, Antony Fearns, Angela Rodgers, Beren Aylan, Laure Botella, Julien Vaubourgeix, Julio Ortiz Canseco, Natalia Athanasiadi, Maximiliano G Gutierrez
Nature Communications 17:9164 (2026)10.1038/s41467-026-75915-8
2026
An ART-fold Rhs toxin from Pluralibacter gergoviae defines Tne5, a novel family of NAD(P) glycohydrolases effectors
Jonas B Desjardins, Martin Durrmeyer, Olivier Bornet, Eric Cascales
Journal of Biological Chemistry 302:113182 (2026)10.1016/j.jbc.2026.113182
2026
Cell polarity control by an unconventional G-protein complex in bacteria
Céline Dinet, Corinne Sebban-Kreuzer, Deborah Byrne-Kodjabachian, Sébastien Lhospice, Julien Herrou, Fabien Durbesson, Renaud Vincentelli, Vincent Calvez, James N. Sturgis, Alphée Michelot, Tâm Mignot
Nature Communications 17:7518 (2026)10.1038/s41467-026-74081-1
2026
Oxadiazolone Derivatives: Powerful Tools to Reduce Staphylococcus aureus Infection
Emma Forest, Jordan Lehoux, Léo Faion, David Ranava, Virginie Mohymont, Thierry Durand, Stéphane Audebert, Luc Camoin, Céline Crauste, Stéphane Canaan, Jean Michel Brunel, Françoise Van Bambeke, Jean-Michel Bolla, Jean-François Cavalier
ACS Infectious Diseases Online ahead of print (2026)10.1021/acsinfecdis.6c00165
2026
Revisiting lactococcal abortive infection-like antiphage systems: Diversity, structures and mechanisms
Andriana Grafakou, Cas Mosterd, Simon A Jackson, Paul P de Waal, Noël N M E van Peij, Christian Cambillau, Jennifer Mahony, Douwe van Sinderen
FEMS Microbiology Reviews Online ahead of print (2026)10.1093/femsre/fuag009
2026
Atypical thioredoxin Patrx2 enhances alginate production in mucoid Pseudomonas aeruginosa
Marie M Grandjean, James N Sturgis, Edwige B Garcin, Moly Ba, Olivier Bornet, Christophe Bordi, Latifa Elantak, Corinne Sebban-Kreuzer
Redox Biology 90:104010 (2026)10.1016/j.redox.2026.104010
2026
Snapshot based on whole-genome sequencing revealing the species and antimicrobial susceptibility profiles of Mycobacterium tuberculosis complex recovered at a major tertiary care center in Lebanon
Israa El Jouaid, Ghena Sobh, Wafaa Achache, Sima Tokajian, Ghiles Grine, Charbel Al Khoury, Fadi Abdel-Sater, Jamal Saad, George F Araj, Michel Drancourt
BMC Infectious Diseases 26:395 (2026)10.1186/s12879-026-12609-y
2026
“Molecular insights into the bactericidal toxin Tle1 of Pseudomonas aeruginosa: Interaction with VgrG, its adaptor, and its immunity protein”
Delphine Lefebvre, Chantal Soscia, Laura Schmitt, Adeline Goulet, Bérengère Ize, Sophie Bleves
Journal of Biological Chemistry 302:111416 (2026)10.1016/j.jbc.2026.111416
2026
Smooth-to-rough morphotype switching, a mechanism of phage resistance in Mycobacterium abscessus
Jun Hao Liew, Ayuni Norman, Morgane Illouz, Teck-Hui Teo, Riccardo Delli Ponti, Claire Hamela, Lalit Mohan, Renee Lew, Chanvutha Ron, Kay En Low, Wassim Daher, Aryeh Chiam, Joanna Maw, Yan Sun, Ria Sorayah, Stefan Oehlers, Byung Woo Jhun, Jeanette W P Teo, Adeline Goulet, Isabelle Bonne, René Wintjens, Kevin Pethe, Roland G Huber, Laurent Kremer, Pablo Bifani
Proceedings of the National Academy of Sciences of the United States of America 123:e2531197123 (2026)10.1073/pnas.2531197123
2026
Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors
Julius Martinkus, Nadège Ginibre Supersac, Nicolas Rivard, Ludovic Belot, Julien Brillard, Eric Cascales, Dukas Jurėnas
Current Biology 36:176-187.e3 (2026)10.1016/j.cub.2025.11.047
2026
Type VI and type IX secretion systems and gliding motility contribute to facultative predation by Flavobacterium johnsoniae
Maelle Paillat, Linghan Coralie Meng, Laure Journet, Eric Cascales, Thierry Doan
Current Biology 36:2649-2661.e6 (2026)10.1016/j.cub.2026.04.042
2026
Interfacial effects break the canonical permeability-selectivity trade-off in biological nanopores
María Queralt-Martín, Laidy M Alvero-Gonzalez, Marcel Aguilella-Arzo, D. Aurora Perini, Lucie A Bergdoll, Antonio Alcaraz
Journal of Colloid and Interface Science 703:139266 (2026)10.1016/j.jcis.2025.139266
2026
A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC1 Oligomerization Inhibitor
Varun Ravishankar, Luís Borges-Araújo, Megha Rajendran, Elodie Lafargue, Deborah Byrne, Nicolas Buzhinsky, Mya Wolfe, Wendy Fitzgerald, Nina Bautista, Bethel Beyene, Motahareh Larimi, Jean-Pierre Duneau, James Sturgis, Sergey Bezrukov, Ignacio Casuso, Tatiana Rostovtseva, Lucie Bergdoll
eLife (2026)10.7554/eLife.111980.2
2026
Anti-type VI tactics: bacterial defenses against type VI secretion system attacks
Nicolas Rivard, Julius Martinkus, Margot Dessartine, Jean-Philippe Côté, Eric Cascales
Trends in Biochemical Sciences 51:816-826 (2026)10.1016/j.tibs.2026.02.017
2026
Phenotypic heterogeneity optimizes trade-offs during adaptive deployment of the type VI secretion system
Boris Taillefer, Florian Schattenberg, Thierry Doan, Susann Müller, Eric Cascales
PLoS Biology 24:e3003838 (2026)10.1371/journal.pbio.3003838
2026
Identification of Fluoro-methoxy-phenyl-substituted N-sulfonylpiperidine-mono-spiro-1,2,4,5-tetraoxanes as Multispecies-targeting Molecules
Mohit Tiwari, Pawel Bakun, Emma Forest, Jean-Michel Bola, Marek Murias, Malgorzata Kucinska, Agnieszka Zgoła-Grześkowiak, Emilia Cicha, Łukasz Marczak, Jean-Franҫois Cavalier, Philippe Grellier, Tomasz Goslinski
European Journal of Medicinal Chemistry 311:118826 (2026)10.1016/j.ejmech.2026.118826
2026
Green synthesis, antibacterial activity and molecular docking study of γ-phosphonyloxime derivatives
Aymen Wahbi, Aicha Mhamdi, Wiem Tahri, Imen Dridi, Mohamed Ali Dridi, Werner Kamisky, Kamel Kaabi, Abdelwaheb Chatti, Cherif Ben Nasr, Jean‐françois Cavalier, Soufiane Touil
ChemistrySelect 11 (2026)10.1002/slct.74508
2026
Biodiversity of skunaviruses isolated from dairy fermentation facilities employing undefined mesophilic starter cultures
Kelsey White, Giovanni Eraclio, Gabriele Andrea Lugli, Marco Ventura, Natalia Biere, Frank Hille, Federica Volonté, Charles M.A.P. Franz, Christian Cambillau, Fabio Dal Bello, Jennifer Mahony, Douwe van Sinderen
International Journal of Food Microbiology 446:111509 (2026)10.1016/j.ijfoodmicro.2025.111509
2026
A T4SS effector directly disarms competing antibacterial T6SSs by hijacking their conserved spike component
Dan Xiong, Jinxing Liao, Zhiyuan Zhang, Julien Giraud, Xiuyuan Li, Dongjing Cheng, Bingxin Wang, Limin Wang, Xiaolong Shao, Long Lin, Jinshui Zheng, Xiangyang Li, Fengquan Liu, Eric Cascales, Guoliang Qian
Science China Life Sciences 69:2045-2059 (2026)10.1007/s11427-026-3315-0
2026
Functional Evaluation of a Conserved HNH Endonuclease Gene in Lactococcal Skunavirus Genomes
Jun‐hyeok Yu, Frank Hille, Christian Cambillau, Natalia Biere, Arjen Nauta, Charles M a P Franz, Jennifer Mahony, Douwe van Sinderen
Microbial Biotechnology 19:e70326 (2026)10.1111/1751-7915.70326