2018
2018
Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation
Fabien Bastaert, Saadé Kheir, Vinciane Saint-Criq, Bérengère Villeret, Pham My-Chan Dang, Jamel El-Benna, Jean-Claude Sirard, Romé Voulhoux, Jean-Michel Sallenave
Frontiers in Immunology 9:1675 (2018)10.3389/fimmu.2018.01675
2018
United we stand, divided we fall
Sophie Bleves, Benjamin Berni
Nature Microbiology (2018)10.1038/s41564-018-0130-x
2018
Antibacterial Weapons: Targeted Destruction in the Microbiota
Benoit Chassaing, E. Cascales
Trends in Microbiology 26:329-338 (2018)10.1016/j.tim.2018.01.006
2018
Biogenesis and structure of a type VI secretion baseplate
Yassine Cherrak, Chiara Rapisarda, Riccardo Pellarin, Guillaume Bouvier, Benjamin Bardiaux, Fabrice Allain, Christian Malosse, Martial Jean-Pierre Rey, Julia Chamot-Rooke, E. Cascales, Rémi Fronzes, Eric Durand
Nature Microbiology 3:1404-1416 (2018)10.1038/s41564-018-0260-1
2018
Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test
Laurent Dortet, Rémy Bonnin, Ivana Pennisi, Laura Gauthier, Agnès Jousset, Laura Dabos, R Christopher D Furniss, Despoina Mavridou, Pierre Bogaerts, Youri Glupczynski, Anaïs Potron, Patrick Plesiat, Racha Beyrouthy, Frédéric Robin, Richard Bonnet, Thierry Naas, Alain Filloux, Gerald Larrouy-Maumus, Lauraine Gauthier
Journal of Antimicrobial Chemotherapy 73:3359-3367 (2018)10.1093/jac/dky330
2018
Structure–Function Analysis of the C-Terminal Domain of the Type VI Secretion TssB Tail Sheath Subunit
Badreddine Douzi, Laureen Logger, Silvia Spinelli, Stephanie Blangy, Christian Cambillau, E. Cascales
Journal of Molecular Biology 430:297-309 (2018)10.1016/j.jmb.2017.11.015
2018
Multiple Structures Disclose the Secretins' Secrets
Alain Filloux, Romé Voulhoux
Journal of Bacteriology 200 (2018)10.1128/JB.00702-17
2018
Genome wide identification and experimental validation of Pseudomonas aeruginosa Tat substrates
Maxime Rémi Gimenez, Govind Chandra, Perrine van Overvelt, Romé Voulhoux, Sophie Bleves, Bérengère Ize
Scientific Reports 8:11950 (2018)10.1038/s41598-018-30393-x
2018
Linking glucose metabolism to the stringent response through the PTS
Richard Gourse, Emmanuelle Bouveret
Proceedings of the National Academy of Sciences of the United States of America 115:7454-7455 (2018)10.1073/pnas.1809265115
2018
Constitutive activation of MexT by amino acid substitutions results in MexEF-OprN overproduction in clinical isolates of Pseudomonas aeruginosa
Paulo Juarez, Isabelle Broutin, Christophe Bordi, Patrick Plesiat, Catherine Llanes
Antimicrobial Agents and Chemotherapy (2018)10.1128/AAC.02445-17
2018
Type IX secretion system PorM and gliding machinery GldM form extended arches spanning the periplasmic space
Philippe Leone, Jennifer Roche, Maxence S Vincent, Quang Hieu Tran, Aline Desmyter, E. Cascales, Christine Kellenberger, Christian Cambillau, Alain Roussel
Nature Communications 9 (2018)10.1038/s41467-017-02784-7
2018
Direct interactions between the secreted effector and the T2SS components GspL and GspM reveal a new effector-sensing step during type 2 secretion
Sandra Michel-Souzy, Badreddine Douzi, Frederic Cadoret, Claire Raynaud, Loïc Quinton, Genevieve Ball, Romé Voulhoux
Journal of Biological Chemistry 293:19441-19450 (2018)10.1074/jbc.RA117.001127
2018
Out-of-Equilibrium Collective Oscillation as Phonon Condensation in a Model Protein
Ilaria Nardecchia, Jeremie Torres, Mathias Lechelon, Valeria Giliberti, Michele Ortolani, Philippe Nouvel, Matteo Gori, Yoann Meriguet, Irene Donato, Jordane Preto, Luca Varani, James N. Sturgis, Marco Pettini
Physical Review X 8:031061 (2018)10.1103/physrevx.8.031061
2018
Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in Mycobacterium tuberculosis
Phuong Chi Nguyen, van Son Nguyen, Benjamin Martin, Patrick Fourquet, Luc Camoin, Chistopher Spilling, Jean-François Cavalier, Christian Cambillau, Stéphane Canaan
Journal of Molecular Biology 430:5129-5136 (2018)10.1016/j.jmb.2018.09.017
2018
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis
Phuong Chi Nguyen, Vincent Delorme, Anaïs Benarouche, Alexandre Guy, Valérie Landry, Stéphane Audebert, Matthieu Pophillat, Luc Camoin, Céline Crauste, Jean-Marie Galano, Thierry Durand, Priscille Brodin, Stéphane Canaan, Jean-François Cavalier
Bioorganic Chemistry 81:414-424 (2018)10.1016/j.bioorg.2018.08.025
2018
Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases
Phuong Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher D Spilling, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan
International Journal of Antimicrobial Agents (2018)10.1016/j.ijantimicag.2017.12.001
2018
Towards a complete structural deciphering of Type VI secretion system
van Son Nguyen, Badreddine Douzi, Eric Durand, Alain Roussel, E. Cascales, Christian Cambillau
Current Opinion in Structural Biology 49:77-84 (2018)10.1016/j.sbi.2018.01.007
2018
The potent effect of mycolactone on lipid membranes
Milène Nitenberg, Anaïs Benarouche, Ofélia Maniti, Estelle Marion, Laurent L Marsollier, Julie Géan, Erick J Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P Girard-Egrot
PLoS Pathogens 14:e1006814 (e-collection 2018 jan) (2018)10.1371/journal.ppat.1006814
2018
The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly
Melvin G Renault, Jordi Zamarreño Beas, Badreddine Douzi, Maïalène Chabalier, Abdelrahim Zoued, Yannick R Brunet, Christian Cambillau, Laure Journet, E. Cascales
Journal of Molecular Biology 430:3143-3156 (2018)10.1016/j.jmb.2018.07.018
2018
In vivo TssA proximity labeling reveals temporal interactions during Type VI secretion 1 biogenesis and TagA, a protein that stops and holds the sheath.
Yoann G Santin, Thierry Doan, Régine Lebrun, Leon Espinosa, Laure Journet, E. Cascales
Nature Microbiology 3:1304-1313 (2018)10.1038/s41564-018-0234-3
2018
Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages
Pierre Santucci, Sadia Diomandé, Isabelle Poncin, Laetitia Alibaud, Albertus Viljoen, Laurent Kremer, Chantal de Chastellier, Stéphane Canaan
Infection and Immunity 86 (2018)10.1128/IAI.00394-18
2018
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling
Pierre Santucci, Vanessa Point, Isabelle Poncin, Alexandre Guy, Céline Crauste, Carole Serveau-Avesque, Jean marie Galano, Chistopher d. Spilling, Jean-François Cavalier, Stéphane Canaan
Bioscience Reports 38:BSR20181953 (2018)10.1042/BSR20181953
2018
Lipid Droplets Breakdown: Adipose Triglyceride Lipase Leads the Way
Pierre Santucci, Stéphane Canaan
Current Protein and Peptide Science 19:1131-1133 (2018)10.2174/1389203719666180809143000
2018
Modifying Styrene-maleic Acid Co-polymer for Studying Lipid Nanodiscs by Direct Fluorescent Labeling
Victoria Schmidt, James N. Sturgis
Bio-protocol 8 (2018)10.21769/BioProtoc.2969
2018
Modifying styrene-maleic acid co-polymer for studying lipid nanodiscs
Victoria Schmidt, James N. Sturgis
Biochimica et Biophysica Acta:Biomembranes 1860:777-783 (2018)10.1016/j.bbamem.2017.12.012
2018
Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo
Albertus Viljoen, Matthias Richard, Phuong Chi Nguyen, Patrick Fourquet, Luc Camoin, Rishi R. Paudal, Giri R Gnawali, Christopher D Spilling, Jean-François Cavalier, Stéphane Canaan, Mickaël Blaise, Laurent Kremer
Journal of Biological Chemistry 293:2755-2769 (2018)10.1074/jbc.RA117.000760
2018
Tryptophan-mediated Dimerization of the TssL Transmembrane Anchor Is Required for Type VI Secretion System Activity
Abdelrahim Zoued, Jean-Pierre Duneau, Eric Durand, Alexandre España, Laure Journet, Françoise Guerlesquin, E. Cascales
Journal of Molecular Biology 430:987-1003 (2018)10.1016/j.jmb.2018.02.008