Philippe Leone
CRCN, CNRS
Publications
2024
2024
Beyond the coupled distortion model: structural analysis of the single domain cupredoxin AcoP, a green mononuclear copper centre with original features
Magali Roger, Philippe Leone, Ninian J Blackburn, Sam Horrell, Tadeo Moreno Chicano, Frédéric Biaso, Marie-Thérèse Giudici-Orticoni, Luciano A Abriata, Greg L Hura, Michael A Hough, Giuliano Sciara, Marianne Ilbert
Dalton Transactions 53:1794-1808 (2024)10.1039/d3dt03372d
2022
2022
Structural and functional analyses of the Porphyromonas gingivalis type IX secretion system PorN protein
Olivier Fuchsbauer, Ignacio Lunar Silva, Eric Cascales, Alain Roussel, Philippe Leone
Journal of Biological Chemistry 298:101618 (2022)10.1016/j.jbc.2022.101618
2021
2021
A new non-classical fold of varroa odorant-binding proteins reveals a wide open internal cavity
Beatrice Amigues, Jiao Zhu, Anais Gaubert, Giovanni Renzone, Philippe Leone, Simona Arena, Isabella Maria Fischer, Harald Paulsen, Wolfgang Knoll, Andrea Scaloni, Alain Roussel, Christian Cambillau, Paolo Pelosi
Scientific Reports (2021)
2021
Anchoring the T6SS to the Cell Wall: Crystal Structure of the Peptidoglycan Binding Domain of the TagL Accessory Protein
Van Son Nguyen, Silvia Spinelli, Éric Cascales, Alain Roussel, Christian Cambillau, Philippe Leone
PLoS ONE (2021)
2021
Anchoring the T6SS to the cell wall: Crystal structure of the peptidoglycan binding domain of the TagL accessory protein
van Son Nguyen, Silvia Spinelli, E. Cascales, Alain Roussel, Christian Cambillau, Philippe Leone
PLoS ONE 16:e0254232 (2021)10.1371/journal.pone.0254232
2021
Crystal structures of two camelid nanobodies raised against GldL, a component of the Type IX Secretion System from Flavobacterium johnsoniae
Thi Trang Nhung, Anaïs Gaubert, Pauline Melani, Christian Cambillau, Alain Roussel, Philippe Leone
Acta crystallographica Section F : Structural biology communications [2014-...] (2021)
2020
2020
Extracellular vesicles as a platform to study cell-surface membrane proteins
Vincent Delauzun, Beatrice Amigues, Anais Gaubert, Philippe Leone, Magali Grange, Laurent Gauthier, Alain Roussel
Methods 180:35-44 (2020)10.1016/j.ymeth.2020.03.004
2020
Crystal structure of Type IX secretion system PorE C-terminal domain from Porphyromonas gingivalis in complex with a peptidoglycan fragment
Nhung Thi Trang Trinh, Hieu Quang Tran, Quyen van Dong, Christian Cambillau, Alain Roussel, Philippe Leone
Scientific Reports 10 (2020)10.1038/s41598-020-64115-z
2018
2018
Type IX secretion system PorM and gliding machinery GldM form extended arches spanning the periplasmic space
Philippe Leone, Jennifer Roche, Maxence S Vincent, Quang Hieu Tran, Aline Desmyter, E. Cascales, Christine Kellenberger, Christian Cambillau, Alain Roussel
Nature Communications 9 (2018)10.1038/s41467-017-02784-7
2017
2017
Camelid nanobodies used as crystallization chaperones for different constructs of PorM, a component of the type IX secretion system from Porphyromonas gingivalis
Yoan Duhoo, Jennifer Roche, Thi Trang Nhung Trinh, Aline Desmyter, Anaïs Gaubert, Christine Kellenberger, Christian Cambillau, Alain Roussel, Philippe Leone
Acta crystallographica Section F : Structural biology communications [2014-...] 73:286-293 (2017)10.1107/S2053230X17005969
2017
Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex
Maxence S Vincent, Mickaël J Canestrari, Philippe Leone, Julien Stathopulos, Bérengère Ize, Abdelrahim Zoued, Christian Cambillau, Christine Kellenberger, Alain Roussel, E. Cascales
Journal of Biological Chemistry 292:3252-3261 (2017)10.1074/jbc.M116.765081
2016
2016
Ultrafast charge–discharge characteristics of a nanosized core–shell structured LiFePO4 material for hybrid supercapacitor applications
Katsuhiko Naoi, Kazuaki Kisu, Etsuro Iwama, Shota Nakashima, Yuki Sakai, Yuki Orikasa, Philippe Leone, Nicolas Dupré, Thierry Brousse, Patrick Rozier, Wako Naoi, Patrice Simon
Energy & Environmental Science vol. 9:pp. 2143-2151 (2016)10.1039/c6ee00829a
2015
2015
X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form
Philippe Leone, Cecilia Bebeacua, Onya Opota, Christine Kellenberger, Bruno Klaholz, Igor Orlov, Christian Cambillau, Bruno Lemaitre, Alain Roussel
Journal of Biological Chemistry 290:13191-13201 (2015)10.1074/jbc.M115.646109
2015
Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen-allergic patients
E. Nony, J. Bouley, M. Le Mignon, P. Lemoine, K. Jain, S. Horiot, L. Mascarell, M. Pallardy, R. Vincentelli, Philippe Leone, A. Roussel, T. Batard, K. Abiteboul, B. Robin, O. de Beaumont, M. Arvidsson, S. Rak, P. Moingeon
Allergy 70:795-804 (2015)10.1111/all.12622
2015
Crystallization and preliminary X-ray analysis of the C-terminal fragment of PorM, a subunit of the Porphyromonas gingivalis type IX secretion system
Julien Stathopulos, Christian Cambillau, E. Cascales, Alain Roussel, Philippe Leone
Acta crystallographica Section F : Structural biology communications [2014-...] 71:71-74 (2015)10.1107/S2053230X1402559X
2014
2014
Thermochromism in Yttrium Iron Garnet Compounds
Hélène Sérier-Brault, Lucile Thibault, Magalie Legrain, Philippe Deniard, Xavier Rocquefelte, Philippe Leone, Jean-Luc Perillon, Stéphanie Le Bris, Jean Waku, Stéphane Jobic
Inorganic Chemistry 53:12378-12383 (2014)10.1021/ic501708b
2013
2013
Crystallization and preliminary X-ray analysis of monalysin, a novel β-pore-forming toxin from the entomopathogen Pseudomonas entomophila
Philippe Leone, Maryline Blemont, Renaud Vincentelli, Christine Kellenberger, Onya Opota, Bruno Lemaitre, Alain Roussel
Acta Crystallographica Section F: Structural Biology and Crystallization Communications 69:930-933 (2013)10.1107/S174430911301885X
2012
2012
Stoichiometric Arsenopyrite, FeAsS, from La Roche-Balue Quarry, Loire-Atlantique, France: Crystal Structure and Mossbauer Study
Luca Bindi, Yves Moelo, Philippe Leone, Michel Suchaud
The Canadian Mineralogist 50:471 (2012)10.3749/canmin.50.2.471
2011
2011
The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway
Nada Basbous, Franck Coste, Philippe Leone, Renaud Vincentelli, Julien Royet, Christine Kellenberger, Alain Roussel
EMBO Reports 12:327-333 (2011)10.1038/embor.2011.19
2011
Structure-Function Analysis of Grass Clip Serine Protease Involved in Drosophila Toll Pathway Activation
Christine Kellenberger, Philippe Leone, Laurent Coquet, Thierry Jouenne, Jean-Marc Reichhart, Alain Roussel
Journal of Biological Chemistry 286:12300-12307 (2011)10.1074/jbc.M110.182741
2011
2010
2010
Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions.
Philippe Leone, Davide Comoletti, Géraldine Ferracci, Sandrine Conrod, Simon U Garcia, Palmer Taylor, Yves Bourne, Pascale Marchot
EMBO Journal 29:2461-71 (2010)10.1038/emboj.2010.123
2010
Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: A comparison with acetylcholinesterase.
Philippe Leone, Davide Comoletti, Palmer Taylor, Yves Bourne, Pascale Marchot
Chemico-Biological Interactions epub ahead of print (2010)10.1016/j.cbi.2010.01.030
2008
2008
Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan
Philippe Leone, Vincent Bischoff, Christine Kellenberger, Charles Hetru, Julien Royetd, Alain Roussel
Molecular Immunology 45:2521-2530 (2008)10.1016/j.molimm.2008.01.015
2008
Structure of Locusta migratoria protease inhibitor 3 (LMPI-3) in complex with Fusarium oxysporum trypsin
Philippe Leone, Alain Roussel, Christine Kellenberger
Acta crystallographica Section D : Structural biology [1993-...] 64:1165-1171 (2008)10.1107/S0907444908030400
2007
2007
Structural Analysis of the Synaptic Protein Neuroligin and Its β-Neurexin Complex: Determinants for Folding and Cell Adhesion
Igor Fabrichny, Philippe Leone, Gerlind Sulzenbacher, Davide Comoletti, Meghan Miller, Palmer Taylor, Yves Bourne, Pascale Marchot
Neuron 56:979-991 (2007)10.1016/j.neuron.2007.11.013
2007
Structural basis for AMP binding to mammalian AMP-activated protein kinase
Bing Xiao, Richard Heath, Peter Saiu, Fiona Leiper, Philippe Leone, Chun Jing, Philip Walker, Lesley Haire, John Eccleston, Colin Davis, Stephen Martin, David Carling, Steven Gamblin
Nature 449:496-500 (2007)10.1038/nature06161
2006
2006
Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-Å
Philippe Leone, Laurence Menu-Bouaouiche, Willy Peumans, Françoise Payan, Annick Barre, Alain Roussel, Els J.M. van Damme, Pierre Rougé
Biochimie 88:45-52 (2006)10.1016/j.biochi.2005.07.001
2004
2004
The Dual Nature of the Wheat Xylanase Protein Inhibitor XIP-I
Françoise Payan, Philippe Leone, Sophie Porciero, Caroline Furniss, Tariq Tahir, Gary Williamson, Anne Durand, Paloma Manzanares, Harry Gilbert, Nathalie Juge, Alain Roussel
Journal of Biological Chemistry 279:36029-36037 (2004)10.1074/jbc.M404225200
2003
2003
Selective Inhibition of Trypsins by Insect Peptides: Role of P6−P10 Loop
Philippe Leone, C. Kellenberger, G. Ferrat, H. Darbon, A. Roussel
Biochemistry 42:13605-13612 (2003)10.1021/bi035318t
1999
1999
Concomitant Intercalation and Decomplexation of Ferrocene Sulfonates in Layered Double Hydroxides
Sandrine Morlat-Therias, Christine Mousty, Pierre Palvadeau, Philippe Molinie, Philippe Leone, Jean Rouxel, Christine Taviot-Gueho, Abderrahman Ennaqui, André de Roy, Pierre Besse
Journal of Solid State Chemistry 144:143-151 (1999)10.1006/jssc.1999.8134
1997
1997
XAS study of the structural and electronic changes in the negative electrode LiNiVO4 during battery discharge
Christine Mousty, S. Therias, Bettina Aboab, Philippe Molinie, M. Queignec, Philippe Leone, Cécile Rossignol, Pierre Palvadeau
New Journal of Chemistry 21:pp. 1321-1330 (1997)