Research group: Host-Pathogen Interaction

Phone: +33 (0)4 91 16 41 24

Room: BM303

Publications

2022

2022
Structural and functional analyses of the Porphyromonas gingivalis type IX secretion system PorN protein

Olivier Fuchsbauer, Ignacio Lunar Silva, Eric Cascales, Alain Roussel, Philippe Leone

Journal of Biological Chemistry 298 (2022)10.1016/j.jbc.2022.101618

2021

2021
A new non-classical fold of varroa odorant-binding proteins reveals a wide open internal cavity

Beatrice Amigues, Jiao Zhu, Anais Gaubert, Giovanni Renzone, Philippe Leone, Simona Arena, Isabella Maria Fischer, Harald Paulsen, Wolfgang Knoll, Andrea Scaloni, Alain Roussel, Christian Cambillau, Paolo Pelosi

Scientific Reports (2021)

2021
Anchoring the T6SS to the Cell Wall: Crystal Structure of the Peptidoglycan Binding Domain of the TagL Accessory Protein

Van Son Nguyen, Silvia Spinelli, Éric Cascales, Alain Roussel, Christian Cambillau, Philippe Leone

PLoS ONE (2021)

2021
Anchoring the T6SS to the cell wall: Crystal structure of the peptidoglycan binding domain of the TagL accessory protein

van Son Nguyen, Silvia Spinelli, E. Cascales, Alain Roussel, Christian Cambillau, Philippe Leone

PLoS ONE 16:e0254232 (2021)10.1371/journal.pone.0254232

2021
Crystal structures of two camelid nanobodies raised against GldL, a component of the Type IX Secretion System from Flavobacterium johnsoniae

Thi Trang Nhung, Anaïs Gaubert, Pauline Melani, Christian Cambillau, Alain Roussel, Philippe Leone

Acta crystallographica Section F : Structural biology communications [2014-...] (2021)

2020

2020
Extracellular vesicles as a platform to study cell-surface membrane proteins

Vincent Delauzun, Beatrice Amigues, Anais Gaubert, Philippe Leone, Magali Grange, Laurent Gauthier, Alain Roussel

Methods 180:35-44 (2020)10.1016/j.ymeth.2020.03.004

2020
Crystal structure of Type IX secretion system PorE C-terminal domain from Porphyromonas gingivalis in complex with a peptidoglycan fragment

Nhung Thi Trang Trinh, Hieu Quang Tran, Quyen van Dong, Christian Cambillau, Alain Roussel, Philippe Leone

Scientific Reports 10 (2020)10.1038/s41598-020-64115-z

2018

2018
Type IX secretion system PorM and gliding machinery GldM form extended arches spanning the periplasmic space

Philippe Leone, Jennifer Roche, Maxence S Vincent, Quang Hieu Tran, Aline Desmyter, E. Cascales, Christine Kellenberger, Christian Cambillau, Alain Roussel

Nature Communications 9 (2018)10.1038/s41467-017-02784-7

2017

2017
Camelid nanobodies used as crystallization chaperones for different constructs of PorM, a component of the type IX secretion system from Porphyromonas gingivalis

Yoan Duhoo, Jennifer Roche, Thi Trang Nhung Trinh, Aline Desmyter, Anaïs Gaubert, Christine Kellenberger, Christian Cambillau, Alain Roussel, Philippe Leone

Acta crystallographica Section F : Structural biology communications [2014-...] 73:286-293 (2017)10.1107/S2053230X17005969

2017
Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex

Maxence S Vincent, Mickaël J Canestrari, Philippe Leone, Julien Stathopulos, Bérengère Ize, Abdelrahim Zoued, Christian Cambillau, Christine Kellenberger, Alain Roussel, E. Cascales

Journal of Biological Chemistry 292:3252-3261 (2017)10.1074/jbc.M116.765081

2016

2016
Ultrafast charge–discharge characteristics of a nanosized core–shell structured LiFePO4 material for hybrid supercapacitor applications

Katsuhiko Naoi, Kazuaki Kisu, Etsuro Iwama, Shota Nakashima, Yuki Sakai, Yuki Orikasa, Philippe Leone, Nicolas Dupré, Thierry Brousse, Patrick Rozier, Wako Naoi, Patrice Simon

Energy & Environmental Science vol. 9:pp. 2143-2151 (2016)10.1039/c6ee00829a

2015

2015
X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form

Philippe Leone, Cecilia Bebeacua, Onya Opota, Christine Kellenberger, Bruno Klaholz, Igor Orlov, Christian Cambillau, Bruno Lemaitre, Alain Roussel

Journal of Biological Chemistry 290:13191-13201 (2015)10.1074/jbc.M115.646109

2015
Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen-allergic patients

E. Nony, J. Bouley, M. Le Mignon, P. Lemoine, K. Jain, S. Horiot, L. Mascarell, M. Pallardy, R. Vincentelli, Philippe Leone, A. Roussel, T. Batard, K. Abiteboul, B. Robin, O. de Beaumont, M. Arvidsson, S. Rak, P. Moingeon

Allergy 70:795-804 (2015)10.1111/all.12622

2015
Crystallization and preliminary X-ray analysis of the C-terminal fragment of PorM, a subunit of the Porphyromonas gingivalis type IX secretion system

Julien Stathopulos, Christian Cambillau, E. Cascales, Alain Roussel, Philippe Leone

Acta crystallographica Section F : Structural biology communications [2014-...] 71:71-74 (2015)10.1107/S2053230X1402559X

2014

2014
Thermochromism in Yttrium Iron Garnet Compounds

Hélène Sérier-Brault, Lucile Thibault, Magalie Legrain, Philippe Deniard, Xavier Rocquefelte, Philippe Leone, Jean-Luc Perillon, Stéphanie Le Bris, Jean Waku, Stéphane Jobic

Inorganic Chemistry 53:12378-12383 (2014)10.1021/ic501708b

2013

2013
Crystallization and preliminary X-ray analysis of monalysin, a novel β-pore-forming toxin from the entomopathogen Pseudomonas entomophila

Philippe Leone, Maryline Blemont, Renaud Vincentelli, Christine Kellenberger, Onya Opota, Bruno Lemaitre, Alain Roussel

Acta Crystallographica Section F: Structural Biology and Crystallization Communications 69:930-933 (2013)10.1107/S174430911301885X

2012

2011

2011
The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway

Nada Basbous, Franck Coste, Philippe Leone, Renaud Vincentelli, Julien Royet, Christine Kellenberger, Alain Roussel

EMBO Reports 12:327-333 (2011)10.1038/embor.2011.19

2011
Structure-Function Analysis of Grass Clip Serine Protease Involved in Drosophila Toll Pathway Activation

Christine Kellenberger, Philippe Leone, Laurent Coquet, Thierry Jouenne, Jean-Marc Reichhart, Alain Roussel

Journal of Biological Chemistry 286:12300-12307 (2011)10.1074/jbc.M110.182741

2011
Kinesin regulation by Salmonella.

Philippe Leone, Stéphane Méresse

Virulence 2:63-6 (2011)

2010

2010
Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions.

Philippe Leone, Davide Comoletti, Géraldine Ferracci, Sandrine Conrod, Simon U Garcia, Palmer Taylor, Yves Bourne, P. Marchot

EMBO Journal 29:2461-71 (2010)10.1038/emboj.2010.123

2010
Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: A comparison with acetylcholinesterase.

Philippe Leone, Davide Comoletti, Palmer Taylor, Yves Bourne, P. Marchot

Chem Biol Interact epub ahead of print (2010)10.1016/j.cbi.2010.01.030

2008

2008
Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan

Philippe Leone, Vincent Bischoff, Christine Kellenberger, Charles Hetru, Julien Royetd, Alain Roussel

Molecular Immunology 45:2521-2530 (2008)10.1016/j.molimm.2008.01.015

2008
Structure of Locusta migratoria protease inhibitor 3 (LMPI-3) in complex with Fusarium oxysporum trypsin

Philippe Leone, Alain Roussel, Christine Kellenberger

Acta crystallographica Section D : Structural biology [1993-...] 64:1165-1171 (2008)10.1107/S0907444908030400

2007

2007
Structural Analysis of the Synaptic Protein Neuroligin and Its β-Neurexin Complex: Determinants for Folding and Cell Adhesion

Igor Fabrichny, Philippe Leone, Gerlind Sulzenbacher, Davide Comoletti, Meghan Miller, Palmer Taylor, Yves Bourne, P. Marchot

Neuron 56:979-991 (2007)10.1016/j.neuron.2007.11.013

2007
Structural basis for AMP binding to mammalian AMP-activated protein kinase

Bing Xiao, Richard Heath, Peter Saiu, Fiona Leiper, Philippe Leone, Chun Jing, Philip Walker, Lesley Haire, John Eccleston, Colin Davis, Stephen Martin, David Carling, Steven Gamblin

Nature 449:496-500 (2007)10.1038/nature06161

2006

2006
Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-Å

Philippe Leone, Laurence Menu-Bouaouiche, Willy Peumans, Françoise Payan, Annick Barre, Alain Roussel, Els J.M. van Damme, Pierre Rougé

Biochimie 88:45-52 (2006)10.1016/j.biochi.2005.07.001

2004

2004
The Dual Nature of the Wheat Xylanase Protein Inhibitor XIP-I

Françoise Payan, Philippe Leone, Sophie Porciero, Caroline Furniss, Tariq Tahir, Gary Williamson, Anne Durand, Paloma Manzanares, Harry Gilbert, Nathalie Juge, Alain Roussel

Journal of Biological Chemistry 279:36029-36037 (2004)10.1074/jbc.M404225200

2003

2003
Selective Inhibition of Trypsins by Insect Peptides: Role of P6−P10 Loop

Philippe Leone, C. Kellenberger, G. Ferrat, H. Darbon, A. Roussel

Biochemistry 42:13605-13612 (2003)10.1021/bi035318t

1999

1999
Concomitant Intercalation and Decomplexation of Ferrocene Sulfonates in Layered Double Hydroxides

Sandrine Morlat-Therias, Christine Mousty, Pierre Palvadeau, Philippe Molinie, Philippe Leone, Jean Rouxel, Christine Taviot-Gueho, Abderrahman Ennaqui, André de Roy, Pierre Besse

Journal of Solid State Chemistry 144:143-151 (1999)10.1006/jssc.1999.8134

1997

1997
XAS study of the structural and electronic changes in the negative electrode LiNiVO4 during battery discharge

Christine Mousty, S. Therias, Bettina Aboab, Philippe Molinie, M. Queignec, Philippe Leone, Cécile Rossignol, Pierre Palvadeau

New Journal of Chemistry 21:pp. 1321-1330 (1997)

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