Laure Journet
DR2, CNRS
Research group: Assembly of bacterial multi-protein complexes
Phone: +33 (0)4 91 16 44 62
Room: B211
Publications
2024
2024
The type VI secretion system of Stenotrophomonas rhizophila CFBP13503 limits the transmission of Xanthomonas campestris pv. campestris 8004 from radish seeds to seedlings
Tiffany Garin, Chrystelle Brin, Anne Préveaux, Agathe Brault, Martial Briand, Marie Simonin, Matthieu Barret, Laure Journet, Alain Sarniguet
Molecular Plant Pathology 25:e13412 (2024)10.1111/mpp.13412
2023
2023
The tip protein PAAR is required for the function of the type VI secretion system
Solène G Beauvois, Nicolas Flaugnatti, Marianne Ilbert, Marie Boyer, Esther Gavello-Fernandez, Rémi Fronzes, Dukas Jurėnas, Laure Journet
Microbiology Spectrum (2023)10.1128/spectrum.01478-23
2023
Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model
Thi Thu Hang Le, Christine Kellenberger, Marie Boyer, Pierre Santucci, Nicolas Flaugnatti, Eric Cascales, Alain Roussel, Stéphane Canaan, Laure Journet, Christian Cambillau
International Journal of Molecular Sciences 24:1740 (2023)10.3390/ijms24021740
2021
2021
Activity, delivery and diversity of Type VI secretion effectors
Dukas Jurėnas, Laure Journet
Molecular Microbiology 115:383-394 (2021)10.1111/mmi.14648
2020
2020
Structural basis for loading and inhibition of a bacterial T6 SS phospholipase effector by the VgrG spike
Nicolas Flaugnatti, Chiara Rapisarda, Martial Rey, Solène G Beauvois, Viet Anh Nguyen, Stéphane Canaan, Eric Durand, Julia Chamot‐rooke, E. Cascales, Rémi Fronzes, Laure Journet
EMBO Journal 39:e104129 (2020)10.15252/embj.2019104129
2019
2019
Structure and Activity of the Type VI Secretion System
Yassine Cherrak, Nicolas Flaugnatti, Eric Durand, Laure Journet, E. Cascales
Microbiology Spectrum 7 (2019)10.1128/microbiolspec.PSIB-0031-2019
2019
Cell width dictates Type VI secretion tail length
Yoann G Santin, Thierry Doan, Laure Journet, E. Cascales
Current Biology - CB (2019)10.1016/j.cub.2019.08.058
2018
2018
The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly
Melvin G Renault, Jordi Zamarreño Beas, Badreddine Douzi, Maïalène Chabalier, Abdelrahim Zoued, Yannick R Brunet, Christian Cambillau, Laure Journet, E. Cascales
Journal of Molecular Biology 430:3143-3156 (2018)10.1016/j.jmb.2018.07.018
2018
In vivo TssA proximity labeling reveals temporal interactions during Type VI secretion 1 biogenesis and TagA, a protein that stops and holds the sheath.
Yoann G Santin, Thierry Doan, Régine Lebrun, Leon Espinosa, Laure Journet, E. Cascales
Nature Microbiology 3:1304-1313 (2018)10.1038/s41564-018-0234-3
2018
Tryptophan-mediated Dimerization of the TssL Transmembrane Anchor Is Required for Type VI Secretion System Activity
Abdelrahim Zoued, Jean-Pierre Duneau, Eric Durand, Alexandre España, Laure Journet, Françoise Guerlesquin, E. Cascales
Journal of Molecular Biology 430:987-1003 (2018)10.1016/j.jmb.2018.02.008
2017
2017
TssA: The cap protein of the Type VI secretion system tail
Abdelrahim Zoued, Eric Durand, Yoann G Santin, Laure Journet, Alain Roussel, Christian Cambillau, E. Cascales
BioEssays 39 (2017)10.1002/bies.201600262
2016
2016
Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli
Badreddine Douzi, Yannick R Brunet, Silvia Spinelli, Valentine Lensi, Stephanie Blangy, Anant Kumar, Laure Journet, Pierre Legrand, E. Cascales, Christian Cambillau
Scientific Reports 6 (2016)10.1038/srep34405
2016
A phospholipase A 1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery
Nicolas Flaugnatti, Thi Thu Hang Le, Stéphane Canaan, Marie-Stéphanie Aschtgen, Vân Nguyên, Stephanie Blangy, Christine Kellenberger, Alain Roussel, Christian Cambillau, E. Cascales, Laure Journet
Molecular Microbiology 99:1099-1118 (2016)10.1111/mmi.13292
2016
The Type VI Secretion System in Escherichia coli and Related Species
Laure Journet, E. Cascales
EcoSal Plus 7 (2016)10.1128/ecosalplus.ESP-0009-2015
2016
Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut
Thibault G Sana, Nicolas Flaugnatti, Kyler A Lugo, Lilian H Lam, Amanda Jacobson, Virginie Baylot, Eric Durand, Laure Journet, E. Cascales, Denise M Monack
Proceedings of the National Academy of Sciences of the United States of America 113:E5044-E5051 (2016)10.1073/pnas.1608858113
2016
Priming and polymerization of a bacterial contractile tail structure. 1" 2" 17
Abdelrahim Zoued, Eric Durand, Yannick R Brunet, Silvia Spinelli, Badreddine Douzi, Mathilde Guzzo, Nicolas Flaugnatti, Pierre Legrand, Laure Journet, Rémi Fronzes, Tam Mignot, Christian Cambillau, E. Cascales
Nature 531:59-63 (2016)10.1038/nature17182
2016
Structure–Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes
Abdelrahim Zoued, Chloé J Cassaro, Eric Durand, Badreddine Douzi, Alexandre España, Christian Cambillau, Laure Journet, E. Cascales
Journal of Molecular Biology 428:4413-4423 (2016)10.1016/j.jmb.2016.08.030
2014
2014
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.
Eric Durand, Christian Cambillau, E. Cascales, Laure Journet
Trends Microbiol. 22:498-507 (2014)10.1016/j.tim.2014.06.004
2014
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors
Eric Durand, Christian Cambillau, E. Cascales, Laure Journet
Trends in Microbiology 22:498-507 (2014)10.1016/j.tim.2014.06.004
2014
Architecture and assembly of the Type VI secretion system
Abdelrahim Zoued, Yannick Brunet, Eric Durand, Marie-Stéphanie Aschtgen, Laureen Logger, Badreddine Douzi, Laure Journet, Christian Cambillau, E. Cascales
Biochimica et Biophysica Acta - Molecular Cell Research 1843:1664-1673 (2014)10.1016/j.bbamcr.2014.03.018
2014
Architecture and assembly of the Type VI secretion system.
Abdelrahim Zoued, Yannick R Brunet, Eric Durand, Marie-Stéphanie Aschtgen, Laureen Logger, Badreddine Douzi, Laure Journet, Christian Cambillau, E. Cascales
Biochim. Biophys. Acta 1843:1664-73 (2014)10.1016/j.bbamcr.2014.03.018
2013
2013
Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator
Erwan Gueguen, Eric Durand, Xiang y Zhang, Quentin d'Amalric, Laure Journet, E. Cascales
PLoS ONE 8:e66615 (2013)10.1371/journal.pone.0066615
2013
Dissection of the TssB-TssC Interface during Type VI Secretion Sheath Complex Formation
Xiang Y. Zhang, Yannick R Brunet, Laureen Logger, Badreddine Douzi, Christian Cambillau, Laure Journet, E. Cascales
PLoS ONE 8:e81074 (2013)10.1371/journal.pone.0081074
2013
TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System
Abdelrahim Zoued, Eric Durand, Cecilia C. Bebeacua, Yannick R Brunet, Badreddine Douzi, Christian Cambillau, E. Cascales, Laure Journet
Journal of Biological Chemistry 288:27031-27041 (2013)10.1074/jbc.M113.499772
2012
2012
The C‐tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci‐1 Type VI secretion system, is inserted by YidC
Marie-Stéphanie Aschtgen, Abdelrahim Zoued, Roland Lloubès, Laure Journet, E. Cascales
MicrobiologyOpen 1:71-82 (2012)10.1002/mbo3.9
2012
An ABC transporter with two periplasmic binding proteins involved in iron acquisition in Pseudomonas aeruginosa
Karl Brillet, Frank Ruffenach, Hendrik Adams, Laure Journet, Véronique Gasser, Françoise Hoegy, Laurent Guillon, Mélissa Hannauer, Adeline Page, Isabelle Schalk
ACS Chemical Biology 7:2036-2045 (2012)10.1021/cb300330v
2012
Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems.
Eric Durand, Abdelrahim Zoued, Silvia Spinelli, Paul J H Watson, Marie-Stéphanie Aschtgen, Laure Journet, Christian Cambillau, E. Cascales
Journal of Biological Chemistry 287:14157-68 (2012)10.1074/jbc.M111.338731
2012
The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC.
Abdelrahim Zoued, Roland Lloubes, Laure Journet, E. Cascales, Marie-Stéphanie Aschtgen
MicrobiologyOpen 1:71-82 (2012)10.1002/mbo3.9
2011
2011
Mechanism of Ferripyoverdine Uptake by Pseudomonas aeruginosa Outer Membrane Transporter FpvA: No Diffusion Channel Formed at Any Time during Ferrisiderophore Uptake
Mirella Nader, Laure Journet, Ahmed Meksem, Laurent Guillon, Isabelle Schalk
Biochemistry 50:2530-2540 (2011)10.1021/bi101821n
2010
2010
Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation
Emilie Yeterian, Lois W. Martin, Laurent Guillon, Laure Journet, Iain L. Lamont, Isabelle Schalk
Amino Acids 38:1447-1459 (2010)10.1007/s00726-009-0358-0
2007
2007
A beta strand lock exchange for signal transduction in TonB-dependent transducers on the basis of a common structural motif.
David Cobessi, Hervé Célia, Franc Pattus, Laure Journet, Karl Brillet
Structure 11:1383-1391 (2007)10.1016/j.str.2007.08.013
2007
Real time fluorescent resonance energy transfer visualization of ferric pyoverdine uptake in Pseudomonas aeruginosa. A role for ferrous iron.
Jason Greenwald, Françoise Hoegy, Mirella Nader, Laure Journet, Gaëtan L A Mislin, Peter L Graumann, Isabelle J Schalk
Journal of Biological Chemistry 282:2987-95 (2007)10.1074/jbc.M609238200
2007
Identification of residues of FpvA involved in the different steps of Pvd-Fe uptake in Pseudomonas aeruginosa.
Mirella Nader, Wim Dobbelaere, Michel Vincent, Laure Journet, Hendrik Adams, David Cobessi, Jacques Gallay, Isabelle J Schalk
Biochemistry 46:11707-17 (2007)10.1021/bi700997w
2005
2005
Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica.
Céline Agrain, Isabelle Callebaut, Laure Journet, Isabel Sorg, Cécile Paroz, Luís Jaime Mota, Guy R. Cornelis
Molecular Microbiology 51:54-57 (2005)10.1111/j.1365-2958.2005.04534.x
2005
Type III secretion: a secretory pathway serving both motility and virulence (review).
Laure Journet, Kelly T Hughes, Guy R Cornelis
Molecular Membrane Biology 22:41-50 (2005)
2005
Bacterial injectisomes: needle length does matter.
Luís Jaime Mota, Laure Journet, Isabel Sorg, Céline Agrain, Guy R Cornelis
Science 307:1278 (2005)10.1126/science.1107679
2004
2004
Improved methods for producing outer membrane vesicles in Gram-negative bacteria.
Thomas Henry, Stéphanie Pommier, Laure Journet, Alain Bernadac, Jean-Pierre Gorvel, Roland Lloubès
Research in Microbiology 155:437-46 (2004)10.1016/j.resmic.2004.04.007
2003
2003
The needle length of bacterial injectisomes is determined by a molecular ruler.
Laure Journet, Céline Agrain, Petr Broz, Guy R Cornelis
Science 302:1757-60 (2003)10.1126/science.1091422
2003
Genetic analysis of the formation of the Ysc-Yop translocation pore in macrophages by Yersinia enterocolitica: role of LcrV, YscF and YopN.
Marie-Noëlle Marenne, Laure Journet, Luis Jaime Mota, Guy R Cornelis
Microbial Pathogenesis 35:243-58 (2003)
2002
2002
Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.
Emmanuelle Bouveret, Laure Journet, Anne Walburger, E. Cascales, Hélène Bénédetti, Roland Lloubes
Biochimie 84:413-21 (2002)
2001
2001
Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm.
Laure Journet, E. Bouveret, A. Rigal, R Lloubes, C Lazdunski, H Bénédetti
Molecular Microbiology 42:331-44 (2001)
2001
The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity?
Roland Lloubès, E. Cascales, Anne Walburger, Emmanuelle Bouveret, Claude Lazdunski, Alain Bernadac, Laure Journet
Research in Microbiology 152:523-529 (2001)10.1016/s0923-2508(01)01226-8
2000
2000
Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors
C. Lazdunski, E. Bouveret, A Rigal, Laure Journet, R. Lloubes, H. Bénédetti
International Journal of Medical Microbiology 290:337-344 (2000)10.1016/S1438-4221(00)80037-5
1999
1999
Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.
Laure Journet, A Rigal, C Lazdunski, H Bénédetti
Journal of Bacteriology 181:4476-84 (1999)
1998
1998
Colicin import into Escherichia coli cells.
C.J Lazdunski, E. Bouveret, A. Rigal, Laure Journet, R Lloubès, H Bénédetti
Journal of Bacteriology 180:4993-5002 (1998)