Research group: Assembly of bacterial multi-protein complexes

Phone: +33 (0)4 91 16 44 62

Room: B211

Publications

2021

2021
Activity, delivery and diversity of Type VI secretion effectors

Dukas Jurėnas, Laure Journet

Molecular Microbiology 115:383-394 (2021)10.1111/mmi.14648

2020

2020
Structural basis for loading and inhibition of a bacterial T6 SS phospholipase effector by the VgrG spike

Nicolas Flaugnatti, Chiara Rapisarda, Martial Rey, Solène Beauvois, Viet Anh Nguyen, Stéphane Canaan, Eric Durand, Julia Chamot‐rooke, E. Cascales, Rémi Fronzes, Laure Journet

EMBO Journal 39:e104129 (2020)10.15252/embj.2019104129

2019

2019
Structure and Activity of the Type VI Secretion System

Yassine Cherrak, Nicolas Flaugnatti, Eric Durand, Laure Journet, E. Cascales

Microbiology Spectrum 7 (2019)10.1128/microbiolspec.PSIB-0031-2019

2019
Cell width dictates Type VI secretion tail length

Yoann Santin, Thierry Doan, Laure Journet, E. Cascales

Current Biology - CB (2019)10.1016/j.cub.2019.08.058

2018

2018
The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly

Melvin Renault, Jordi Zamarreño Beas, Badreddine Douzi, Maïalène Chabalier, Abdelrahim Zoued, Yannick Brunet, Christian Cambillau, Laure Journet, E. Cascales

Journal of Molecular Biology 430:3143-3156 (2018)10.1016/j.jmb.2018.07.018

2018
In vivo TssA proximity labeling reveals temporal interactions during Type VI secretion 1 biogenesis and TagA, a protein that stops and holds the sheath.

Yoann Santin, Thierry Doan, Régine Lebrun, Leon Espinosa, Laure Journet, E. Cascales

Nature Microbiology 3:1304-1313 (2018)10.1038/s41564-018-0234-3

2018
Tryptophan-mediated Dimerization of the TssL Transmembrane Anchor Is Required for Type VI Secretion System Activity

Abdelrahim Zoued, Jean-Pierre Duneau, Eric Durand, Alexandre España, Laure Journet, Françoise Guerlesquin, E. Cascales

Journal of Molecular Biology 430:987-1003 (2018)10.1016/j.jmb.2018.02.008

2017

2017
TssA: The cap protein of the Type VI secretion system tail

Abdelrahim Zoued, Eric Durand, Yoann Santin, Laure Journet, Alain Roussel, Christian Cambillau, E. Cascales

BioEssays 39 (2017)10.1002/bies.201600262

2016

2016
Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli

Badreddine Douzi, Yannick Brunet, Silvia Spinelli, Valentine Lensi, Stephanie Blangy, Anant Kumar, Laure Journet, Pierre Legrand, E. Cascales, Christian Cambillau

Scientific Reports 6 (2016)10.1038/srep34405

2016
A phospholipase A 1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery

Nicolas Flaugnatti, Thi Thu Hang Le, Stéphane Canaan, Marie-Stéphanie Aschtgen, Vân Nguyên, Stephanie Blangy, Christine Kellenberger, Alain Roussel, Christian Cambillau, E. Cascales, Laure Journet

Molecular Microbiology 99:1099-1118 (2016)10.1111/mmi.13292

2016
Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

Thibault Sana, Nicolas Flaugnatti, Kyler Lugo, Lilian Lam, Amanda Jacobson, Virginie Baylot, Eric Durand, Laure Journet, E. Cascales, Denise Monack

Proceedings of the National Academy of Sciences of the United States of America 113:E5044-E5051 (2016)10.1073/pnas.1608858113

2016
Priming and polymerization of a bacterial contractile tail structure. 1" 2" 17

Abdelrahim Zoued, Eric Durand, Yannick Brunet, Silvia Spinelli, Badreddine Douzi, Mathilde Guzzo, Nicolas Flaugnatti, Pierre Legrand, Laure Journet, Rémi Fronzes, Tam Mignot, Christian Cambillau, E. Cascales

Nature 531:59-63 (2016)10.1038/nature17182

2016
Structure–Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes

Abdelrahim Zoued, Chloé Cassaro, Eric Durand, Badreddine Douzi, Alexandre España, Christian Cambillau, Laure Journet, E. Cascales

Journal of Molecular Biology 428:4413-4423 (2016)10.1016/j.jmb.2016.08.030

2014

2014
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.

Eric Durand, Christian Cambillau, E. Cascales, Laure Journet

Trends Microbiol. 22:498-507 (2014)10.1016/j.tim.2014.06.004

2014
Architecture and assembly of the Type VI secretion system.

Abdelrahim Zoued, Yannick R Brunet, Eric Durand, Marie-Stéphanie Aschtgen, Laureen Logger, Badreddine Douzi, Laure Journet, Christian Cambillau, E. Cascales

Biochim. Biophys. Acta 1843:1664-73 (2014)10.1016/j.bbamcr.2014.03.018

2013

2013
2013
Dissection of the TssB-TssC Interface during Type VI Secretion Sheath Complex Formation

Xiang Zhang, Yannick Brunet, Laureen Logger, Badreddine Douzi, Christian Cambillau, Laure Journet, E. Cascales

PLoS ONE 8:e81074 (2013)10.1371/journal.pone.0081074

2013
TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System

Abdelrahim Zoued, Eric Durand, Cecilia Bebeacua, Yannick Brunet, Badreddine Douzi, Christian Cambillau, E. Cascales, Laure Journet

Journal of Biological Chemistry 288:27031-27041 (2013)10.1074/jbc.M113.499772

2012

2012
Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems.

Eric Durand, Abdelrahim Zoued, Silvia Spinelli, Paul J H Watson, Marie-Stéphanie Aschtgen, Laure Journet, Christian Cambillau, E. Cascales

Journal of Biological Chemistry 287:14157-68 (2012)10.1074/jbc.M111.338731

2012
The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC.

Abdelrahim Zoued, Roland Lloubes, Laure Journet, E. Cascales, Marie-Stéphanie Aschtgen

MicrobiologyOpen 1:71-82 (2012)10.1002/mbo3.9

2011

2010

2010
Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation

Emilie Yeterian, Lois W. Martin, Laurent Guillon, Laure Journet, Iain L. Lamont, Isabelle Schalk

Amino Acids 38:1447-1459 (2010)10.1007/s00726-009-0358-0

2007

2007
A beta strand lock exchange for signal transduction in TonB-dependent transducers on the basis of a common structural motif.

David Cobessi, Hervé Célia, Franc Pattus, Laure Journet, Karl Brillet

Structure 11:1383-1391 (2007)10.1016/j.str.2007.08.013

2007
Real time fluorescent resonance energy transfer visualization of ferric pyoverdine uptake in Pseudomonas aeruginosa. A role for ferrous iron.

Jason Greenwald, Françoise Hoegy, Mirella Nader, Laure Journet, Gaëtan L A Mislin, Peter L Graumann, Isabelle J Schalk

Journal of Biological Chemistry 282:2987-95 (2007)10.1074/jbc.M609238200

2007
Identification of residues of FpvA involved in the different steps of Pvd-Fe uptake in Pseudomonas aeruginosa.

Mirella Nader, Wim Dobbelaere, Michel Vincent, Laure Journet, Hendrik Adams, David Cobessi, Jacques Gallay, Isabelle J Schalk

Biochemistry 46:11707-17 (2007)10.1021/bi700997w

2005

2005
Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica.

Céline Agrain, Isabelle Callebaut, Laure Journet, Isabel Sorg, Cécile Paroz, Luís Jaime Mota, Guy R. Cornelis

Molecular Microbiology 51:54-57 (2005)10.1111/j.1365-2958.2005.04534.x

2005
Type III secretion: a secretory pathway serving both motility and virulence (review).

Laure Journet, Kelly T Hughes, Guy R Cornelis

Molecular Membrane Biology 22:41-50 (2005)

2005
Bacterial injectisomes: needle length does matter.

Luís Jaime Mota, Laure Journet, Isabel Sorg, Céline Agrain, Guy R Cornelis

Science 307:1278 (2005)10.1126/science.1107679

2004

2004
Improved methods for producing outer membrane vesicles in Gram-negative bacteria.

Thomas Henry, Stéphanie Pommier, Laure Journet, Alain Bernadac, Jean-Pierre Gorvel, Roland Lloubès

Research in Microbiology 155:437-46 (2004)10.1016/j.resmic.2004.04.007

2003

2003
The needle length of bacterial injectisomes is determined by a molecular ruler.

Laure Journet, Céline Agrain, Petr Broz, Guy R Cornelis

Science 302:1757-60 (2003)10.1126/science.1091422

2003
Genetic analysis of the formation of the Ysc-Yop translocation pore in macrophages by Yersinia enterocolitica: role of LcrV, YscF and YopN.

Marie-Noëlle Marenne, Laure Journet, Luis Jaime Mota, Guy R Cornelis

Microbial Pathogenesis 35:243-58 (2003)

2002

2002
Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.

Emmanuelle Bouveret, Laure Journet, Anne Walburger, E. Cascales, Hélène Bénédetti, Roland Lloubes

Biochimie 84:413-21 (2002)

2001

2001
Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm.

Laure Journet, E. Bouveret, A. Rigal, R Lloubes, C Lazdunski, H Bénédetti

Molecular Microbiology 42:331-44 (2001)

2000

2000
Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors

C. Lazdunski, E. Bouveret, A Rigal, Laure Journet, R. Lloubes, H. BÉnÉdetti

International Journal of Medical Microbiology 290:337-344 (2000)10.1016/S1438-4221(00)80037-5

1999

1999
Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.

Laure Journet, A Rigal, C Lazdunski, H Bénédetti

Journal of Bacteriology 181:4476-84 (1999)

1998

1998
Colicin import into Escherichia coli cells.

C.J Lazdunski, E. Bouveret, A. Rigal, Laure Journet, R Lloubès, H Bénédetti

Journal of Bacteriology 180:4993-5002 (1998)

© 2021 LISM - Laboratoire d'Ingénierie des Systèmes Macromoléculaires - CNRS UMR7255

31 Chemin Joseph Aiguier, 13402 Marseille cedex 20, France