Research group: Host-Pathogen Interaction

Phone: +33 (0)4 91 16 41 28

Room: BM304

Publications

2022

2022
A structural discovery journey of streptococcal phages adhesion devices by AlphaFold2

Adeline Goulet, Raphaela Joos, Katherine Lavelle, Douwe van Sinderen, Jennifer Mahony, Christian Cambillau

Frontiers in Molecular Biosciences 9 (2022)10.3389/fmolb.2022.960325

2022
Replication of the coronavirus genome: A paradox among positive-strand RNA viruses

Emeline Grellet, India l'Hôte, Adeline Goulet, Isabelle Imbert

Journal of Biological Chemistry 298:101923 (2022)10.1016/j.jbc.2022.101923

2022
A truncated anti-CRISPR protein prevents spacer acquisition but not interference

Cécile Philippe, Carlee Morency, Pier-Luc Plante, Edwige Zufferey, Rodrigo Achigar, Denise M Tremblay, Geneviève M Rousseau, Adeline Goulet, Sylvain Moineau

Nature Communications 13 (2022)10.1038/s41467-022-30310-x

2021

2020

2020
Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9

Daniel Agudelo, Sophie Carter, Minja Velimirovic, Alexis Duringer, Jean-François Rivest, Sébastien Levesque, Jérémy Loehr, Mathilde Mouchiroud, Denis Cyr, Paula Waters, Mathieu Laplante, Sylvain Moineau, Adeline Goulet, Yannick Doyon

Genome Research 30:107-117 (2020)10.1101/gr.255414.119

2020
2020
Diversity of molecular mechanisms used by anti-CRISPR proteins: the tip of an iceberg?

Pierre Hardouin, Adeline Goulet

Biochemical Society Transactions 48:507-516 (2020)10.1042/BST20190638

2020
Revisiting the host adhesion determinants of Streptococcus thermophilus siphophages

Katherine Lavelle, Adeline Goulet, Brian Mcdonnell, Silvia Spinelli, Douwe Van Sinderen, Jennifer Mahony, Christian Cambillau

Microbial Biotechnology 13:1765-1779 (2020)10.1111/1751-7915.13593

2020
Wine phenolic compounds differently affect the host-killing activity of two lytic bacteriophages infecting the lactic acid bacterium oenococcus oeni

Cécile Philippe, Amel Chaib, Fety Jaomanjaka, Stéphanie Cluzet, Aurélie Lagarde, Patricia Ballestra, Alain Decendit, Melina Petrel, Olivier Claisse, Adeline Goulet, Christian C. Cambillau, Claire Le Marrec

Viruses 12:1-19 (2020)10.3390/v12111316

2020
Structural Insights into Lactococcal Siphophage p2 Baseplate Activation Mechanism

Silvia Spinelli, Denise Tremblay, Sylvain Moineau, Christian Cambillau, Adeline Goulet

Viruses 12 (2020)10.3390/v12080878

2019

2019
Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase

Claire Debarnot, Yoan Monneau, Veronique Roig-Zamboni, Vincent Delauzun, Christine Le Narvor, Emeline Richard, Jérôme Hénault, Adeline Goulet, Firas Fadel, Romain R Vivès, Bernard Priem, David Bonnaffé, Hugues Lortat-Jacob, Yves Bourne

Proceedings of the National Academy of Sciences of the United States of America 116:6760-6765 (2019)10.1073/pnas.1818333116

2019
Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6

Olivier Fuchsbauer, Paolo Swuec, Claire Zimberger, Beatrice Amigues, Sébastien Levesque, Daniel Agudelo, Alexis Duringer, Antonio Chaves-Sanjuan, Silvia Spinelli, Geneviève Rousseau, Minja Velimirovic, Martino Bolognesi, Alain Roussel, Christian C. Cambillau, Sylvain Moineau, Yannick Doyon, Adeline Goulet

Molecular Cell 76:922-937.e7 (2019)10.1016/j.molcel.2019.09.012

2018

2018
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

Alexander Hynes, Geneviève Rousseau, Daniel Agudelo, Adeline Goulet, Béatrice Amigues, Jeremy Loehr, Dennis Romero, Christophe Fremaux, Philippe Horvath, Yannick Doyon, Christian Cambillau, Sylvain S. Moineau

Nature Communications 9:2919 (2018)10.1038/s41467-018-05092-w

2017

2017
Toscana virus nucleoprotein oligomer organization observed in solution

Amal Baklouti, Adeline Goulet, Julie Lichiere, Bruno Canard, Remi Charrel, Francois Ferron, Bruno Coutard, Nicolas Papageorgiou

Acta crystallographica Section D : Structural biology [1993-...] 73:650-659 (2017)10.1107/S2059798317008774

2016

2016
Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism

Adeline Goulet, Mishan Britto, Syeda Rizvi, Ottilie von Loeffelholz, Carolyn Moores, Robert Cross

Proceedings of the National Academy of Sciences of the United States of America 113:E7483-E7489 (2016)10.1073/pnas.1611581113

2015

2015
RNA 1 and RNA 2 Genomic Segments of Chronic Bee Paralysis Virus Are Infectious and Induce Chronic Bee Paralysis Disease

Ibrahim Youssef, Frank Schurr, Adeline Goulet, Nicolas Cougoule, Magali Ribiere-Chabert, Herve Darbon, Richard Thiery, Eric Dubois

Journal of Immunology Research 2015:423493 (8 pages) (2015)10.1155/2015/423493

2014

2014
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family

Adeline Goulet, Jennifer Major, Yonggun Jun, Steven Gross, Steven Rosenfeld, Carolyn Moores

Proceedings of the National Academy of Sciences of the United States of America 111:1837-1842 (2014)10.1073/pnas.1319848111

2013

2013
New Insights into the Mechanism of Force Generation by Kinesin-5 Molecular Motors

Adeline Goulet, Carolyn Moores, William Behnke-Parks, Charles Sindelar, Jennifer Major, Steven Rosenfeld

Journal of Biological Chemistry 304:419-466 (2013)10.1016/B978-0-12-407696-9.00008-7

2012

2012
Crystal Structure of ATVORF273, a New Fold for a Thermo- and Acido-Stable Protein from the Acidianus Two-Tailed Virus

Catarina Felisberto-Rodrigues, Stéphanie Blangy, Adeline Goulet, Gisle Vestergaard, Christian Cambillau, Roger Garrett, Miguel Ortiz-Lombardía

PLoS ONE 7:e45847 (2012)10.1371/journal.pone.0045847

2012
The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

Adeline Goulet, William M Behnke-Parks, Charles V Sindelar, Jennifer Major, Steven S Rosenfeld, Carolyn A Moores

Journal of Biological Chemistry 287:44654-44666 (2012)10.1074/jbc.m112.404228

2011

2011
The Opening of the SPP1 Bacteriophage Tail, a Prevalent Mechanism in Gram-positive-infecting Siphophages

Adeline Goulet, Joséphine Lai-Kee-Him, David Veesler, Isabelle Auzat, Gautier Robin, Dale Shepherd, Alison Ashcroft, Eric Richard, Julie Lichière, Paulo Tavares, Christian Cambillau, Patrick Bron

Journal of Biological Chemistry 286:25397-25405 (2011)10.1074/jbc.M111.243360

2009

2009
Acidianus filamentous virus 1 coat proteins display a helical fold spanning the filamentous archaeal viruses lineage.

Adeline Goulet, Stéphanie Blangy, Peter Redder, David Prangishvili, Catarina Felisberto-Rodrigues, Patrick Forterre, Valérie Campanacci, Christian Cambillau

Proceedings of the National Academy of Sciences of the United States of America 106:21155-60 (2009)10.1073/pnas.0909893106

2009
The crystal structure of ORF14 from Sulfolobus islandicus filamentous virus

Adeline Goulet, Silvia Spinelli, Stéphanie Blangy, Herman van Tilbeurgh, Nicolas Leulliot, Tamara Basta, David Prangishvili, Christian Cambillau, Valérie Campanacci

Proteins - Structure, Function and Bioinformatics 76:1020-1022 (2009)10.1002/prot.22448

2009
The thermo- and acido-stable ORF-99 from the archaeal virus AFV1

Adeline Goulet, Silvia Spinelli, Stéphanie Blangy, Herman van Tilbeurgh, Nicolas Leulliot, Tamara Basta, David Prangishvili, Christian Cambillau, Valérie Campanacci

Protein Science 18:1316-1320 (2009)10.1002/pro.122

2006

2006
Crystallization and preliminary X-ray diffraction analysis of protein 14 from Sulfolobus islandicus filamentous virus (SIFV)

Adeline Goulet, Silvia Spinelli, Sophie Porciero, Stéphanie Blangy, Roger Garrett, Herman van Tilbeurgh, Nicolas Leulliot, Tamara Basta, David Prangishvili, Christian Cambillau

Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62:884-886 (2006)10.1107/S1744309106029150

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