Christian Cambillau
DRCE2, CNRS
Emeritus
Research group: Host-Pathogen Interaction
Publications
2024
2024
Molecular mechanisms underlying the structural diversity of rhamnose-rich cell wall polysaccharides in lactococci
Hugo Guérin, Pascal Courtin, Alain Guillot, Christine Péchoux, Jennifer Mahony, Douwe van Sinderen, Saulius Kulakauskas, Christian Cambillau, Thierry Touzé, Marie-Pierre Chapot-Chartier
Journal of Biological Chemistry 300:105578 (2024)10.1016/j.jbc.2023.105578
2023
2023
Exploring Host-Binding Machineries of Mycobacteriophages with AlphaFold2
Christian Cambillau, Adeline Goulet
Journal of Virology 97:01793-22 (2023)10.1128/jvi.01793-22
2023
Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model
Thi Thu Hang Le, Christine Kellenberger, Marie Boyer, Pierre Santucci, Nicolas Flaugnatti, Eric Cascales, Alain Roussel, Stéphane Canaan, Laure Journet, Christian Cambillau
International Journal of Molecular Sciences 24:1740 (2023)10.3390/ijms24021740
2023
Partial Atomic Model of the Tailed Lactococcal Phage TP901-1 as Predicted by AlphaFold2: Revelations and Limitations
Jennifer Mahony, Adeline Goulet, Douwe van Sinderen, Christian Cambillau
Viruses 15 (2023)10.3390/v15122440
2022
2022
SARS-CoV-2 detection using a nanobody-functionalized voltammetric device
Quentin Pagneux, Alain Roussel, Hiba Saada, Christian Cambillau, Béatrice Amigues, Vincent Delauzun, Ilka Engelmann, Enagnon Kazali Alidjinou, Judith Ogiez, Anne Sophie Rolland, Emmanuelle Faure, Julien Poissy, Alain Duhamel, Rabah Boukherroub, David Devos, Sabine Szunerits
Communications Medicine 2:56 (2022)10.1038/s43856-022-00113-8
2022
[Review] The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors
Sabine Szunerits, Quentin Pagneux, Abir Swaidan, Vladyslav Mishyn, Alain Roussel, Christian Cambillau, David Devos, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Happy, Rabah Boukherroub
Analytical and Bioanalytical Chemistry 414:pp 103-113 (2022)10.1007/s00216-020-03137-y
2021
2021
Preanalytical issues and cycle threshold values in SARS-CoV-2 real-time RT-PCR testing: should test results include these?
Ilka Engelmann, Enagnon Kazali Alidjinou, Judith Ogiez, Quentin Pagneux, Sana Miloudi, Ilyes Benhalima, Mahdi Ouafi, Famara Sané, Didier Hober, Alain Roussel, Christian Cambillau, David Devos, Rabah Boukherroub, Sabine Szunerits
ACS Omega 6:6528-6536 (2021)10.1021/acsomega.1c00166
2021
Structure and Topology Prediction of Phage Adhesion Devices Using AlphaFold2: The Case of Two Oenococcus oeni Phages
Adeline Goulet, Christian Cambillau
Microorganisms 9:2151 (2021)10.3390/microorganisms9102151
2021
Anchoring the T6SS to the Cell Wall: Crystal Structure of the Peptidoglycan Binding Domain of the TagL Accessory Protein
Van Son Nguyen, Silvia Spinelli, Éric Cascales, Alain Roussel, Christian Cambillau, Philippe Leone
PLoS ONE (2021)
2021
Anchoring the T6SS to the cell wall: Crystal structure of the peptidoglycan binding domain of the TagL accessory protein
van Son Nguyen, Silvia Spinelli, E. Cascales, Alain Roussel, Christian Cambillau, Philippe Leone
PLoS ONE 16:e0254232 (2021)10.1371/journal.pone.0254232
2021
Crystal structures of two camelid nanobodies raised against GldL, a component of the Type IX Secretion System from Flavobacterium johnsoniae
Thi Trang Nhung, Anaïs Gaubert, Pauline Melani, Christian Cambillau, Alain Roussel, Philippe Leone
Acta crystallographica Section F : Structural biology communications [2014-...] (2021)
2021
Biogenesis of a Bacteriophage Long Non-Contractile Tail
Anait Seul, Sandrine Brasilès, Isabelle Petitpas, Rudi Lurz, Valérie Campanacci, Christian Cambillau, Frank Weise, Mohamed Zairi, Paulo Tavares, Isabelle Auzat
Journal of Molecular Biology 433:167112 (2021)10.1016/j.jmb.2021.167112
2020
2020
Revisiting the host adhesion determinants of Streptococcus thermophilus siphophages
Katherine Lavelle, Adeline Goulet, Brian Mcdonnell, Silvia Spinelli, Douwe Van Sinderen, Jennifer Mahony, Christian Cambillau
Microbial Biotechnology 13:1765-1779 (2020)10.1111/1751-7915.13593
2020
The CWPS Rubik’s cube: Linking diversity of cell wall polysaccharide structures with the encoded biosynthetic machinery of selected Lactococcus lactis strains
Jennifer Mahony, Cyril Frantzen, Evgeny Vinogradov, Irina Sadovskaya, Ilias Theodorou, Philip Kelleher, Marie‐pierre Chapot-Chartier, Christian Cambillau, Helge Holo, Douwe Sinderen
Molecular Microbiology 114:582-596 (2020)10.1111/mmi.14561
2020
Novel Genus of Phages Infecting Streptococcus thermophilus : Genomic and Morphological Characterization
Cécile Philippe, Sébastien Levesque, Moïra Dion, Denise Tremblay, Philippe Horvath, Natascha Lüth, Christian Cambillau, Charles Franz, Horst Neve, Christophe Fremaux, Knut Heller, Sylvain Moineau
Applied and Environmental Microbiology 86 (2020)10.1128/AEM.00227-20
2020
Crystal structure of Type IX secretion system PorE C-terminal domain from Porphyromonas gingivalis in complex with a peptidoglycan fragment
Nhung Thi Trang Trinh, Hieu Quang Tran, Quyen van Dong, Christian Cambillau, Alain Roussel, Philippe Leone
Scientific Reports 10 (2020)10.1038/s41598-020-64115-z
2019
2019
Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6
Olivier Fuchsbauer, Paolo Swuec, Claire Zimberger, Beatrice Amigues, Sébastien Levesque, Daniel Agudelo, Alexis Duringer, Antonio Chaves-Sanjuan, Silvia Spinelli, Geneviève Rousseau, Minja Velimirovic, Martino Bolognesi, Alain Roussel, Christian Cambillau, Sylvain Moineau, Yannick Doyon, Adeline Goulet
Molecular Cell 76:922-937.e7 (2019)10.1016/j.molcel.2019.09.012
2019
Ubiquitous Carbohydrate Binding Modules Decorate 936 Lactococcal Siphophage Virions
Stephen Hayes, Jennifer Mahony, Renaud Vincentelli, Laurie Ramond, Arjen Nauta, Douwe van Sinderen, Christian Cambillau
Viruses 11:631 (2019)10.3390/v11070631
2018
2018
ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets
Matija Brozovic, Christelle Dantec, Justine Dardaillon, Delphine Dauga, Emmanuel Faure, Mathieu Gineste, Alexandra Louis, Magali Naville, Kazuhiro R. Nitta, Jacques Piette, Wendy Reeves, Celine Scornavacca, Paul Simion, Renaud Vincentelli, Maëlle Bellec, Sameh Ben Aicha, Marie Fagotto, Marion Gueroult-Bellone, Maximilian Haeussler, Edwin Jacox, Elijah K. Lowe, Mickaël Mendez, Alexis Roberge, Alberto Stolfi, Rui Yokomori, C. Titus Brown, Christian Cambillau, Lionel Christiaen, Frédéric Delsuc, Emmanuel J.P. Douzery, Rémi Dumollard, Takehiro Kusakabe, Kenta Nakai, Hiroki Nishida, Yutaka Satou, Billie Swalla, Michael Veeman, Jean-Nicolas Volff, Patrick Lemaire
Nucleic Acids Research 46:D718-D725 (2018)10.1093/nar/gkx1108
2018
Structure–Function Analysis of the C-Terminal Domain of the Type VI Secretion TssB Tail Sheath Subunit
Badreddine Douzi, Laureen Logger, Silvia Spinelli, Stephanie Blangy, Christian Cambillau, E. Cascales
Journal of Molecular Biology 430:297-309 (2018)10.1016/j.jmb.2017.11.015
2018
Functional carbohydrate binding modules identified in evolved dits from siphophages infecting various Gram-positive bacteria
Stephen Hayes, Renaud Vincentelli, Jennifer Mahony, Arjen Nauta, Laurie Ramond, Gabriele Lugli, Marco Ventura, Douwe van Sinderen, Christian Cambillau
Molecular Microbiology 110:777-795 (2018)10.1111/mmi.14124
2018
Identification of Dual Receptor Binding Protein Systems in Lactococcal 936 Group Phages
Stephen Hayes, Yoan Duhoo, Horst H. Neve, James Murphy, Jean-Paul Noben, Charles M. A. P. Franz, Christian Cambillau, Jennifer Mahony, Arjen Nauta, Douwe van Sinderen
Viruses 10:668 (2018)10.3390/v10120668
2018
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
Alexander Hynes, Geneviève Rousseau, Daniel Agudelo, Adeline Goulet, Béatrice Amigues, Jeremy Loehr, Dennis Romero, Christophe Fremaux, Philippe Horvath, Yannick Doyon, Christian Cambillau, Sylvain S. Moineau
Nature Communications 9:2919 (2018)10.1038/s41467-018-05092-w
2018
A Decade of Streptococcus thermophilus Phage Evolution in an Irish Dairy Plant
Katherine Lavelle, James Murphy, Brian Fitzgerald, Gabriele Lugli, Aldert Zomer, Horst H. Neve, Marco Ventura, Charles M. A. P. Franz, Christian Cambillau, Douwe van Sinderen, Jennifer Mahony
Applied and Environmental Microbiology 84 (2018)10.1128/AEM.02855-17
2018
Towards a complete structural deciphering of Type VI secretion system
van Son Nguyen, Badreddine Douzi, Eric Durand, Alain Roussel, E. Cascales, Christian Cambillau
Current Opinion in Structural Biology 49:77-84 (2018)10.1016/j.sbi.2018.01.007
2018
Structure of the type VI secretion system TssK–TssF–TssG baseplate subcomplex revealed by cryo-electron microscopy
Young-Jun Park, Kaitlyn Lacourse, Christian Cambillau, Frank Dimaio, Joseph D. Mougous, David Veesler
Nature Communications 9:5385 (2018)10.1038/s41467-018-07796-5
2018
The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly
Melvin G Renault, Jordi Zamarreño Beas, Badreddine Douzi, Maïalène Chabalier, Abdelrahim Zoued, Yannick R Brunet, Christian Cambillau, Laure Journet, E. Cascales
Journal of Molecular Biology 430:3143-3156 (2018)10.1016/j.jmb.2018.07.018
2017
2017
Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions
Els Beirnaert, Aline Desmyter, Silvia Spinelli, Marc Lauwereys, Lucien Aarden, Torsten Dreier, Remy Loris, Karen Silence, Caroline Pollet, Christian Cambillau, Hans de Haard
Frontiers in Immunology 8:867 (2017)10.3389/fimmu.2017.00867
2017
Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine–Nanobody Complex
Aline Desmyter, Silvia Spinelli, Carlo Boutton, Michael Saunders, Christophe Blachetot, Hans de Haard, Geertrui Denecker, Maarten van Roy, Christian Cambillau, Heidi Rommelaere
Frontiers in Immunology 8:884 (2017)10.3389/fimmu.2017.00884
2017
Evolved distal tail carbohydrate binding modules of L actobacillus phage J-1: a novel type of anti-receptor widespread among lactic acid bacteria phages
Maria-Eugenia Dieterle, Silvia Spinelli, Irina I. Sadovskaya, Mariana Piuri, Christian Cambillau
Molecular Microbiology 104:608-620 (2017)10.1111/mmi.13649
2017
Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and Dynamics
Badreddine Douzi, Nhung Trinh, Sandra Michel-Souzy, Aline Desmyter, Genevieve Ball, Pascale Barbier, Artemis Kosta, Eric Durand, Katrina Forest, Christian Cambillau, Alain Roussel, Romé Voulhoux
mBio 8 (2017)10.1128/mBio.01185-17
2017
Camelid nanobodies used as crystallization chaperones for different constructs of PorM, a component of the type IX secretion system from Porphyromonas gingivalis
Yoan Duhoo, Jennifer Roche, Thi Trang Nhung Trinh, Aline Desmyter, Anaïs Gaubert, Christine Kellenberger, Christian Cambillau, Alain Roussel, Philippe Leone
Acta crystallographica Section F : Structural biology communications [2014-...] 73:286-293 (2017)10.1107/S2053230X17005969
2017
Genetic and functional characterisation of the lactococcal P335 phage-host interactions
Jennifer Mahony, Joana Oliveira, Barry Collins, Laurens Hanemaaijer, Gabriele Andrea Lugli, Horst H. Neve, Marco Ventura, Thijs Kouwen, Christian Cambillau, Douwe van Sinderen
BMC Genomics 18:146 (2017)10.1186/s12864-017-3537-5
2017
Host recognition by lactic acid bacterial phages
Jennifer Mahony, Christian Cambillau, Douwe van Sinderen
FEMS Microbiology Reviews 41:S16-S26 (2017)10.1093/femsre/fux019
2017
Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex
van Son Nguyen, Laureen Logger, Silvia Spinelli, Pierre Legrand, Thi Thanh Huyen Pham, Thi Trang Nhung Trinh, Yassine Cherrak, Abdelrahim Zoued, Aline Desmyter, Eric Durand, Alain Roussel, Christine Kellenberger, E. Cascales, Christian Cambillau
Nature Microbiology 2:17103 (2017)10.1038/nmicrobiol.2017.103
2017
Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex
Maxence S Vincent, Mickaël J Canestrari, Philippe Leone, Julien Stathopulos, Bérengère Ize, Abdelrahim Zoued, Christian Cambillau, Christine Kellenberger, Alain Roussel, E. Cascales
Journal of Biological Chemistry 292:3252-3261 (2017)10.1074/jbc.M116.765081
2017
Reverse chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles
Jiao Zhu, Simona Arena, Silvia Spinelli, Dingzhen Liu, Guiquan Zhang, Rongping Wei, Christian Cambillau, Andrea Scaloni, Guirong Wang, Paolo Pelosi
Proceedings of the National Academy of Sciences of the United States of America 114:E9802-E9810 (2017)10.1073/pnas.1711437114
2017
TssA: The cap protein of the Type VI secretion system tail
Abdelrahim Zoued, Eric Durand, Yoann G Santin, Laure Journet, Alain Roussel, Christian Cambillau, E. Cascales
BioEssays 39 (2017)10.1002/bies.201600262
2016
2016
The Baseplate of Lactobacillus delbrueckii Bacteriophage Ld17 Harbors a Glycerophosphodiesterase
Anneleen Cornelissen, Irina Sadovskaya, Evgeny Vinogradov, Stephanie Blangy, Silvia Spinelli, Eoghan Casey, Jennifer Mahony, Jean-Paul Noben, Fabio Dal Bello, Christian Cambillau, Douwe Van Sinderen
Journal of Biological Chemistry 291:16816+ (2016)10.1074/jbc.M116.728279
2016
Characterization of prophages containing "evolved" Dit/Tal modules in the genome of Lactobacillus casei BL23.
María Eugenia Dieterle, Joaquina Fina Martin, Rosario Durán, Sergio I Nemirovsky, Carmen Sanchez Rivas, Charles Bowman, Daniel Russell, Graham F Hatfull, Christian Cambillau, Mariana Piuri
Applied Microbiology and Biotechnology 100:9201-9215 (2016)10.1007/s00253-016-7727-x
2016
Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli
Badreddine Douzi, Yannick R Brunet, Silvia Spinelli, Valentine Lensi, Stephanie Blangy, Anant Kumar, Laure Journet, Pierre Legrand, E. Cascales, Christian Cambillau
Scientific Reports 6 (2016)10.1038/srep34405
2016
A phospholipase A 1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery
Nicolas Flaugnatti, Thi Thu Hang Le, Stéphane Canaan, Marie-Stéphanie Aschtgen, Vân Nguyên, Stephanie Blangy, Christine Kellenberger, Alain Roussel, Christian Cambillau, E. Cascales, Laure Journet
Molecular Microbiology 99:1099-1118 (2016)10.1111/mmi.13292
2016
Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies
Anna Hultberg, Anke Kretz-Rommel, Silvia Spinelli, Remy Loris, Christian Cambillau, Hans De Haard, Christophe Blanchetot, Natalie de Jonge, Aline Desmyter, Nico Ongenae, Erik Hofman, Alex Klarenbeek, Ava Sadi
Journal of Biological Chemistry 291:13846-13854 (2016)10.1074/jbc.M115.695528
2016
Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics
Alex Klarenbeek, Christophe Blanchetot, Georg Schragel, Ava S. Sadi, Nico Ongenae, Wieger Hemrika, John Wijdenes, Silvia Spinelli, Aline Desmyter, Christian Cambillau, Anna Hultberg, Anke Kretz-Rommel, Torsten Dreier, Hans J. W. de Haard, Rob C. Roovers
Protein Engineering, Design and Selection 29:123-133 (2016)10.1093/protein/gzw003
2016
Structure of the host-recognition device of Staphylococcus aureus phage phi 11
Cengiz Koç, Guoqing Xia, Petra Kuehner, Silvia Spinelli, Alain Roussel, Christian Cambillau, Thilo Stehle
Scientific Reports 6 (2016)10.1038/srep27581
2016
The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules
Pierre Legrand, Barry Collins, Stephanie Blangy, James Murphy, Silvia Spinelli, Carlos Gutierrez, Nicolas Richet, Christine Kellenberger, Aline Desmyter, Jennifer Mahony, Douwe Van Sinderen, Christian Cambillau
mBio 7 (2016)10.1128/mBio.01781-15
2016
An essential role for the baseplate protein Gp45 in phage adsorption to Staphylococcus aureus
Xuehua Li, Cengiz Koc, Petra Kuehner, York-Dieter Stierhof, Bernhard Krismer, Mark C. Enright, Jose R. Penades, Christiane Wolz, Thilo Stehle, Christian Cambillau, Andreas Peschel, Guoqing Xia
Scientific Reports 6 (2016)10.1038/srep26455
2016
Functional and structural dissection of the tape measure protein of lactococcal phage TP901-1
Jennifer Mahony, Mona Alqarni, Stephen Stockdale, Silvia Spinelli, Marine Feyereisen, Christian Cambillau, Douwe Van Sinderen
Scientific Reports 6 (2016)10.1038/srep36667
2016
Priming and polymerization of a bacterial contractile tail structure. 1" 2" 17
Abdelrahim Zoued, Eric Durand, Yannick R Brunet, Silvia Spinelli, Badreddine Douzi, Mathilde Guzzo, Nicolas Flaugnatti, Pierre Legrand, Laure Journet, Rémi Fronzes, Tam Mignot, Christian Cambillau, E. Cascales
Nature 531:59-63 (2016)10.1038/nature17182
2016
Structure–Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes
Abdelrahim Zoued, Chloé J Cassaro, Eric Durand, Badreddine Douzi, Alexandre España, Christian Cambillau, Laure Journet, E. Cascales
Journal of Molecular Biology 428:4413-4423 (2016)10.1016/j.jmb.2016.08.030
2015
2015
Bacteriophage module reshuffling results in adaptive host range as exemplified by the baseplate model of listerial phage A118
Christian Cambillau
Virology 484:86-92 (2015)10.1016/j.virol.2015.05.015
2015
Camelid nanobodies: killing two birds with one stone
Aline Desmyter, Silvia Spinelli, Alain Roussel, Christian Cambillau
Current Opinion in Structural Biology 32:1-8 (2015)10.1016/j.sbi.2015.01.001
2015
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform
Alex Klarenbeek, Khalil El Mazouari, Aline Desmyter, Christophe Blanchetot, Anna Hultberg, Natalie De Jonge, Rob C. Roovers, Christian Cambillau, Sylvia Spinelli, Jurgen Del-Favero, Theo Verrips, Hans J. De Haard, Ikbel Achour
mAbs 7:693-706 (2015)10.1080/19420862.2015.1046648
2015
X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form
Philippe Leone, Cecilia Bebeacua, Onya Opota, Christine Kellenberger, Bruno Klaholz, Igor Orlov, Christian Cambillau, Bruno Lemaitre, Alain Roussel
Journal of Biological Chemistry 290:13191-13201 (2015)10.1074/jbc.M115.646109
2015
The targeted recognition of Lactococcus lactis phages to their polysaccharide receptors
Orla Mccabe, Silvia Spinelli, Carine Farenc, Myriam Labbe, Denise Tremblay, Stephanie Blangy, Stefan Oscarson, Sylvain Moineau, Christian Cambillau
Molecular Microbiology 96:875-886 (2015)10.1111/mmi.12978
2015
Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody
van Son Nguyen, Laureen Logger, Silvia Spinelli, Aline Desmyter, Thi Thu Hang Le, Christine Kellenberger, Badreddine Douzi, Eric Durand, Alain Roussel, E. Cascales, Christian Cambillau
PLoS ONE 10:1-14 (2015)
2015
Production, crystallization and X-ray diffraction analysis of a complex between a fragment of the TssM T6SS protein and a camelid nanobody
van Son Nguyen, Silvia Spinelli, Aline Desmyter, Thi Thu Hang Le, Christine Kellenberger, E. Cascales, Christian Cambillau, Alain Roussel
Acta crystallographica Section F : Structural biology communications [2014-...] 71:266-271 (2015)10.1107/S2053230X15000709
2015
Crystallization and preliminary X-ray analysis of the C-terminal fragment of PorM, a subunit of the Porphyromonas gingivalis type IX secretion system
Julien Stathopulos, Christian Cambillau, E. Cascales, Alain Roussel, Philippe Leone
Acta crystallographica Section F : Structural biology communications [2014-...] 71:71-74 (2015)10.1107/S2053230X1402559X
2015
Structure and Assembly of TP901-1 Virion Unveiled by Mutagenesis
Stephen R. Stockdale, Barry Collins, Silvia Spinelli, François P. Douillard, Jennifer Mahony, Christian Cambillau, Douwe van Sinderen
PLoS ONE 1-22 (2015)10.1371/journal.pone.0131676
2014
2014
Differences in lactococcal cell wall polysaccharide structure are major determining factors in bacteriophage sensitivity
Stuart Ainsworth, Irina Sadovskaya, Evguenii Vinogradov, Pascal Courtin, Yann Guerardel, Jennifer Mahony, Thierry Grard, Christian Cambillau, Marie-Pierre Chapot-Chartier, Douwe van Sinderen
mBio 5:np (2014)10.1128/mBio.00880-14
2014
Crystal Structure and Self-Interaction of the Type VI Secretion Tail-Tube Protein from Enteroaggregative Escherichia coli
Badreddine Douzi, Silvia Spinelli, Stéphanie Blangy, Alain Roussel, Eric Durand, Yannick Brunet, E. Cascales, Christian Cambillau
PLoS ONE 9:e86918 (2014)10.1371/journal.pone.0086918
2014
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.
Eric Durand, Christian Cambillau, E. Cascales, Laure Journet
Trends Microbiol. 22:498-507 (2014)10.1016/j.tim.2014.06.004
2014
VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors
Eric Durand, Christian Cambillau, E. Cascales, Laure Journet
Trends in Microbiology 22:498-507 (2014)10.1016/j.tim.2014.06.004
2014
A Cutinase from Trichoderma reesei with a Lid-Covered Active Site and Kinetic Properties of True Lipases
Alain Roussel, Sawsan Amara, Antti Nyyssölä, Eduardo Mateos-Diaz, Stéphanie Blangy, Hanna Kontkanen, Ann Westerholm-Parvinen, Frédéric Carrière, Christian Cambillau
Journal of Molecular Biology 426:3757-3772 (2014)10.1016/j.jmb.2014.09.003
2014
Architecture and assembly of the Type VI secretion system
Abdelrahim Zoued, Yannick Brunet, Eric Durand, Marie-Stéphanie Aschtgen, Laureen Logger, Badreddine Douzi, Laure Journet, Christian Cambillau, E. Cascales
Biochimica et Biophysica Acta - Molecular Cell Research 1843:1664-1673 (2014)10.1016/j.bbamcr.2014.03.018
2014
Architecture and assembly of the Type VI secretion system.
Abdelrahim Zoued, Yannick R Brunet, Eric Durand, Marie-Stéphanie Aschtgen, Laureen Logger, Badreddine Douzi, Laure Journet, Christian Cambillau, E. Cascales
Biochim. Biophys. Acta 1843:1664-73 (2014)10.1016/j.bbamcr.2014.03.018
2013
2013
Biochemical and structural characterization of non-glycosylated Yarrowia lipolytica LIP2 lipase
Ahmed Aloulou, Anaïs Bénarouche, Delphine Puccinelli, Silvia Spinelli, Jean-François Cavalier, Christian Cambillau, Frédéric Carrière
European Journal of Lipid Science and Technology 115:429-441 (2013)10.1002/ejlt.201200440
2013
X-ray structure of a superinfection exclusion lipoprotein from phage TP-J34 and identification of the tape measure protein as its target
Cecilia C. Bebeacua, Juan Carlos Lorenzo Fajardo, Stéphanie Blangy, Silvia Spinelli, Stefanie Bollmann, Horst H. Neve, Christian Cambillau, Knut Heller
Molecular Microbiology 89:152-165 (2013)10.1111/mmi.12267
2013
Dissection of the TssB-TssC Interface during Type VI Secretion Sheath Complex Formation
Xiang Y. Zhang, Yannick R Brunet, Laureen Logger, Badreddine Douzi, Christian Cambillau, Laure Journet, E. Cascales
PLoS ONE 8:e81074 (2013)10.1371/journal.pone.0081074
2013
TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System
Abdelrahim Zoued, Eric Durand, Cecilia C. Bebeacua, Yannick R Brunet, Badreddine Douzi, Christian Cambillau, E. Cascales, Laure Journet
Journal of Biological Chemistry 288:27031-27041 (2013)10.1074/jbc.M113.499772
2012
2012
Structural biology of type VI secretion systems
E. Cascales, Christian Cambillau
Philosophical Transactions of the Royal Society B: Biological Sciences 367:1102-1111 (2012)10.1098/rstb.2011.0209
2012
Structural biology of type VI secretion systems.
E. Cascales, Christian Cambillau
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 367:1102-11 (2012)10.1098/rstb.2011.0209
2012
Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system.
Eric Durand, Estelle Derrez, Gilles Audoly, Silvia Spinelli, Miguel Ortiz-Lombardia, Didier Raoult, E. Cascales, Christian Cambillau
Journal of Biological Chemistry 287:38190-9 (2012)10.1074/jbc.M112.390153
2012
Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems.
Eric Durand, Abdelrahim Zoued, Silvia Spinelli, Paul J H Watson, Marie-Stéphanie Aschtgen, Laure Journet, Christian Cambillau, E. Cascales
Journal of Biological Chemistry 287:14157-68 (2012)10.1074/jbc.M111.338731
2012
Crystal Structure of the VgrG1 Actin Cross-linking Domain of the Vibrio cholerae Type VI Secretion System
Eric Durand, Estelle Derrez, Gilles Audoly, Silvia Spinelli, Miguel Ortiz-Lombardia, Didier Raoult, E. Cascales, Christian Cambillau
Journal of Biological Chemistry 287:38190-38199 (2012)10.1074/jbc.M112.390153
2012
Crystal Structure of ATVORF273, a New Fold for a Thermo- and Acido-Stable Protein from the Acidianus Two-Tailed Virus
Catarina Felisberto-Rodrigues, Stéphanie Blangy, Adeline Goulet, Gisle Vestergaard, Christian Cambillau, Roger Garrett, Miguel Ortiz-Lombardía
PLoS ONE 7:e45847 (2012)10.1371/journal.pone.0045847
2011
2011
Deciphering the Xcp Pseudomonas aeruginosa type II secretion machinery through multiple interactions with substrates.
Badreddine Douzi, Geneviève Ball, Christian Cambillau, Mariella Tegoni, Romé Voulhoux
Journal of Biological Chemistry 286:40792-801 (2011)10.1074/jbc.M111.294843
2011
Towards a Structural Comprehension of Bacterial Type VI Secretion Systems: Characterization of the TssJ-TssM Complex of an Escherichia coli Pathovar
Catarina Felisberto-Rodrigues, Eric Durand, Marie-Stéphanie Aschtgen, Stéphanie Blangy, Miguel Ortiz-Lombardia, Badreddine Douzi, Christian Cambillau, E. Cascales
PLoS Pathogens 7:e1002386 (2011)10.1371/journal.ppat.1002386
2011
Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar
Catarina Felisberto-Rodrigues, Eric Durand, Marie-Stéphanie Aschtgen, Stephanie Blangy, Miguel Ortiz-Lombardia, Badreddine Douzi, Christian Cambillau, E. Cascales
PLoS Pathogens 7:e1002386 (2011)10.1371/journal.ppat.1002386
2011
The Opening of the SPP1 Bacteriophage Tail, a Prevalent Mechanism in Gram-positive-infecting Siphophages
Adeline Goulet, Joséphine Lai-Kee-Him, David Veesler, Isabelle Auzat, Gautier Robin, Dale Shepherd, Alison Ashcroft, Eric Richard, Julie Lichière, Paulo Tavares, Christian Cambillau, Patrick Bron
Journal of Biological Chemistry 286:25397-25405 (2011)10.1074/jbc.M111.243360
2010
2010
Solution and electron microscopy characterization of lactococcal phage baseplates expressed in Escherichia coli.
Valérie Campanacci, David Veesler, Julie Lichière, Stéphanie Blangy, Giuliano Sciara, Sylvain Moineau, Douwe van Sinderen, Patrick Bron, Christian Cambillau
Journal of Structural Biology 172:75-84 (2010)10.1016/j.jsb.2010.02.007
2010
Mammalian G protein-coupled receptor expression in Escherichia coli: II. Refolding and biophysical characterization of mouse cannabinoid receptor 1 and human parathyroid hormone receptor 1.
Kerstin Michalke, Céline Huyghe, Julie Lichière, Marie-Eve Gravière, Marina Siponen, Giuliano Sciara, Isabelle Lepaul, Renaud Wagner, Christine Magg, Rainer Rudolph, Christian Cambillau, Aline Desmyter
Analytical Biochemistry 401:74-80 (2010)10.1016/j.ab.2010.02.017
2010
Structure of lactococcal phage p2 baseplate and its mechanism of activation.
Giuliano Sciara, Cecilia Bebeacua, Patrick Bron, Denise Tremblay, Miguel Ortiz-Lombardia, Julie Lichière, Marin van Heel, Valérie Campanacci, Sylvain Moineau, Christian Cambillau
Proceedings of the National Academy of Sciences of the United States of America 107:6852-7 (2010)10.1073/pnas.1000232107
2010
Crystal structure of Bacillus subtilis SPP1 phage gp22 shares fold similarity with a domain of lactococcal phage p2 RBP
David Veesler, Stéphanie Blangy, Silvia Spinelli, Paulo Tavares, Valérie Campanacci, Christian Cambillau
Protein Science 19:1439-1443 (2010)10.1002/pro.416
2010
Crystal structure of Bacillus subtilis SPP1 phage gp23.1, a putative chaperone
David Veesler, Stéphanie Blangy, Julie Lichiere, Miguel Ortiz-Lombardía, Paulo Tavares, Valérie Campanacci, Christian Cambillau
Protein Science 19:1812-1816 (2010)10.1002/pro.464
2009
2009
Surfactant Poloxamer 188 as a New Crystallizing Agent for Urate Oxidase
Marion Giffard, Vanessa Delfosse, Giuliano Sciara, Claudine Mayer, Christian Cambillau, Mohamed El Hajji, Bertrand Castro, Françoise Bonneté
Crystal Growth & Design 9:4199-4206 (2009)10.1021/cg900473n
2009
Acidianus filamentous virus 1 coat proteins display a helical fold spanning the filamentous archaeal viruses lineage.
Adeline Goulet, Stéphanie Blangy, Peter Redder, David Prangishvili, Catarina Felisberto-Rodrigues, Patrick Forterre, Valérie Campanacci, Christian Cambillau
Proceedings of the National Academy of Sciences of the United States of America 106:21155-60 (2009)10.1073/pnas.0909893106
2009
The crystal structure of ORF14 from Sulfolobus islandicus filamentous virus
Adeline Goulet, Silvia Spinelli, Stéphanie Blangy, Herman van Tilbeurgh, Nicolas Leulliot, Tamara Basta, David Prangishvili, Christian Cambillau, Valérie Campanacci
Proteins - Structure, Function and Bioinformatics 76:1020-1022 (2009)10.1002/prot.22448
2009
The thermo- and acido-stable ORF-99 from the archaeal virus AFV1
Adeline Goulet, Silvia Spinelli, Stéphanie Blangy, Herman van Tilbeurgh, Nicolas Leulliot, Tamara Basta, David Prangishvili, Christian Cambillau, Valérie Campanacci
Protein Science 18:1316-1320 (2009)10.1002/pro.122
2009
Mammalian G-protein-coupled receptor expression in Escherichia coli: I. High-throughput large-scale production as inclusion bodies
Kerstin Michalke, Marie-Eve Gravière, Céline Huyghe, Renaud Vincentelli, Renaud Wagner, Franc Pattus, Kathrin Schroeder, Jan Oschmann, Rainer Rudolph, Christian Cambillau, Aline Desmyter
Analytical Biochemistry 386:147-155 (2009)10.1016/j.ab.2008.12.016
2009
Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release
Marion E. Pesenti, Silvia Spinelli, Valérie Bézirard, Loïc Briand, J Claude Pernollet, Valérie Campanacci, Mariella Tegoni, Christian Cambillau
Journal of Molecular Biology 390:981-990 (2009)10.1016/j.jmb.2009.05.067
2009
Crystal structure of ORF12 from Lactococcus lactis phage p2 identifies a tape measure protein chaperone.
Marina Siponen, Giuliano Sciara, Manuela Villion, Silvia Spinelli, Julie Lichière, Christian Cambillau, Sylvain Moineau, Valérie Campanacci
Journal of Bacteriology 191:728-34 (2009)10.1128/JB.01363-08
2009
Production and biophysical characterization of the CorA transporter from Methanosarcina mazei.
David Veesler, Stéphanie Blangy, Marina Siponen, Renaud Vincentelli, Christian Cambillau, Giuliano Sciara
Analytical Biochemistry 388:115-21 (2009)10.1016/j.ab.2009.02.018
2008
2008
Structure of Human Pancreatic Lipase-Related Protein 2 with the Lid in an Open Conformation ,
Cécilia Eydoux, Silvia Spinelli, Tara Davis, John Walker, Alma Seitova, Sirano Dhe-Paganon, Alain de Caro, Christian Cambillau, Frédéric Carrière
Biochemistry 47:9553-9564 (2008)10.1021/bi8005576
2008
Structural basis of the honey bee PBP pheromone and pH-induced conformational change
Marion E. Pesenti, Silvia Spinelli, Valérie Bézirard, Loïc Briand, J Claude Pernollet, Mariella Tegoni, Christian Cambillau
Journal of Molecular Biology 380:158-169 (2008)10.1016/j.jmb.2008.04.048