Jean-François Cavalier
DR2, CNRS
Publications
2024
2024
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus
Magali Casanova, Marc Maresca, Isabelle Poncin, Vanessa Point, Hamza Olleik, Céline Boidin-Wichlacz, Aurélie Tasiemski, Kamel Mabrouk, Jean-François Cavalier, Stéphane Canaan
Journal of Biomedical Science 31:18 (2024)10.1186/s12929-024-01007-8
2024
Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities
Attilio Di Maio, Hamza Olleik, Elise Courvoisier-Dezord, Sophie Guillier, Fabienne Neulat-Ripoll, Romain Haudecoeur, Jean-Michel Bolla, Magali Casanova, Jean-François Cavalier, Stéphane Canaan, Valérie Pique, Yolande Charmasson, Elias Baydoun, Akram Hijazi, Josette Perrier, Marc Maresca, Maxime Robin
Antibiotics 13 (2024)10.3390/antibiotics13040300
2023
2023
Evaluation of the Efficiency of Random and Diblock Methacrylate-Based Amphiphilic Cationic Polymers against Major Bacterial Pathogens Associated with Cystic Fibrosis
Magali Casanova, Hamza Olleik, Slim Hdiouech, Clarisse Roblin, Jean-François Cavalier, Vanessa Point, Katy Jeannot, Baptiste Caron, Josette Perrier, Siméon Charriau, Mickael Lafond, Yohann Guillaneuf, Stéphane Canaan, Catherine Lefay, Marc Maresca
Antibiotics 12:120 (2023)10.3390/antibiotics12010120
2022
2022
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis
Sarah Barelier, Romain Avellan, Giri Raj Gnawali, Patrick Fourquet, Véronique Roig-Zamboni, Isabelle Poncin, Vanessa Point, Yves Bourne, Stéphane Audebert, Luc Camoin, Christopher Spilling, Stéphane Canaan, Jean‐françois Cavalier, Gerlind Sulzenbacher
FEBS Journal (2022)10.1111/febs.16645
2022
Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives
Vasiliki Mavrikaki, Alexandros Pagonis, Isabelle Poncin, Ivy Mallick, Stéphane Canaan, Victoria Magrioti, Jean-François Cavalier
Bioorganic and Medicinal Chemistry Letters 64:128692 (2022)10.1016/j.bmcl.2022.128692
2022
Synthesis and Biological Characterization of Fluorescent Cyclipostins and Cyclophostin Analogues: New Insights for the Diagnosis of Mycobacterial-Related Diseases
Morgane Sarrazin, Benjamin Martin, Romain Avellan, Giri Raj Gnawali, Isabelle Poncin, Hugo Le Guenno, Christopher Spilling, Jean-François Cavalier, Stéphane Canaan
ACS Infectious Diseases (2022)10.1021/acsinfecdis.2c00448
2021
2021
Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis?
Ivy Mallick, Pierre Santucci, Isabelle Poncin, Vanessa Point, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan
FEMS Microbiology Reviews (2021)10.1093/femsre/fuab029
2020
2020
Lipolytic enzymes inhibitors: A new way for antibacterial drugs discovery
Jean-François Cavalier, Christopher D Spilling, Thierry Durand, Luc Camoin, Stéphane Canaan
European Journal of Medicinal Chemistry 112908 (2020)10.1016/j.ejmech.2020.112908
2020
Experimental and computational investigation of Z/E isomerism, X-ray crystal structure and molecular docking study of (2-(hydroxyimino)cyclohexyl)diphenylphosphine sulfide, a potential antibacterial agent
Nejib Jebli, Youssef Arfaoui, Kristof van Hecke, Jean-François Cavalier, Soufiane Touil
Journal of Molecular Structure 129634 (2020)10.1016/j.molstruc.2020.129634
2020
Synthesis, antimicrobial activity and molecular docking study of novel α‐(diphenylphosphoryl)‐ and α‐(diphenylphosphorothioyl)cycloalkanone oximes
Nejib Jebli, Selma Hamimed, Kristof van Hecke, Jean-François Cavalier, Soufiane Touil
Chemistry and Biodiversity 17:e2000217 (2020)10.1002/cbdv.202000217
2020
Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus
Abdeldjalil Madani, Ivy Mallick, Alexandre Guy, Céline Crauste, Thierry Durand, Patrick Fourquet, Stéphane Audebert, Luc Camoin, Stéphane Canaan, Jean-François Cavalier
PLoS ONE 15:e0238178 (2020)10.1371/journal.pone.0238178
2019
2019
Design, synthesis, antimicrobial evaluation, and molecular docking studies of novel symmetrical 2,5‐difunctionalized 1,3,4‐oxadiazoles
Shaima Hkiri, Afifa Hafidh, Jean-François Cavalier, Soufiane Touil, Ali Samarat
Journal of Heterocyclic Chemistry (2019)10.1002/jhet.3837
2019
Cyclipostins and Cyclophostin Analogues as Multitarget Inhibitors That Impair Growth of Mycobacterium abscessus
Abdeldjalil Madani, Jeremy Ridenour, Benjamin Martin, Rishi Paudel, Anosha Abdul Basir, Vincent Le Moigne, Jean-Louis Herrmann, Stéphane Audebert, Luc Camoin, Laurent Kremer, Christopher D Spilling, Stéphane Canaan, Jean-François Cavalier
ACS Infectious Diseases (2019)10.1021/acsinfecdis.9b00172
2019
Worms’ Antimicrobial Peptides
Bruno Renato, Marc Maresca, Stéphane Canaan, Jean-François Cavalier, Kamel Mabrouk, Céline Boidin-Wichlacz, Hamza Olleik, Daniela Zeppilli, Priscille Brodin, François Massol, Didier Jollivet, Sacha Jung, Aurélie Tasiemski
Marine drugs 17:512 (2019)10.3390/md17090512
2019
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains
Pierre Santucci, Nabil Smichi, Sadia Diomandé, Isabelle Poncin, Vanessa Point, Hélène Gaussier, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan
FEBS Journal (2019)10.1111/febs.14864
2019
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria
Pierre Santucci, Matt Johansen, Vanessa Point, Isabelle Poncin, Albertus Viljoen, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan
Scientific Reports 9 (2019)10.1038/s41598-019-45164-5
2019
Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria
Pierre Santucci, Christina Dedaki, Alexandros Athanasoulis, Laura Gallorini, Anaïs Munoz, Stéphane Canaan, Jean-François Cavalier, Victoria Magrioti
ChemMedChem 14:349-358 (2019)10.1002/cmdc.201800720
2019
Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility
Dong Yang, Guy Vandenbussche, Didier Vertommen, Damien Evrard, Romany Abskharon, Jean-François Cavalier, Gilles Berger, Stéphane Canaan, Mohammad Shahneawz Khan, Sheng Zeng, Alexandre Wohlkonig, Martine Prévost, Patrice Soumillion, Véronique Fontaine
FEBS Letters (2019)10.1002/1873-3468.13555
2018
2018
Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in Mycobacterium tuberculosis
Phuong Chi Nguyen, van Son Nguyen, Benjamin Martin, Patrick Fourquet, Luc Camoin, Chistopher Spilling, Jean-François Cavalier, Christian Cambillau, Stéphane Canaan
Journal of Molecular Biology 430:5129-5136 (2018)10.1016/j.jmb.2018.09.017
2018
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis
Phuong Chi Nguyen, Vincent Delorme, Anaïs Benarouche, Alexandre Guy, Valérie Landry, Stéphane Audebert, Matthieu Pophillat, Luc Camoin, Céline Crauste, Jean-Marie Galano, Thierry Durand, Priscille Brodin, Stéphane Canaan, Jean-François Cavalier
Bioorganic Chemistry 81:414-424 (2018)10.1016/j.bioorg.2018.08.025
2018
Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases
Phuong Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher D Spilling, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan
International Journal of Antimicrobial Agents (2018)10.1016/j.ijantimicag.2017.12.001
2018
The potent effect of mycolactone on lipid membranes
Milène Nitenberg, Anaïs Benarouche, Ofélia Maniti, Estelle Marion, Laurent L Marsollier, Julie Géan, Erick J Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P Girard-Egrot
PLoS Pathogens 14:e1006814 (e-collection 2018 jan) (2018)10.1371/journal.ppat.1006814
2018
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling
Pierre Santucci, Vanessa Point, Isabelle Poncin, Alexandre Guy, Céline Crauste, Carole Serveau-Avesque, Jean-Marie Galano, Chistopher d. Spilling, Jean-François Cavalier, Stéphane Canaan
Bioscience Reports 38:BSR20181953 (2018)10.1042/BSR20181953
2018
Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo
Albertus Viljoen, Matthias Richard, Phuong Chi Nguyen, Patrick Fourquet, Luc Camoin, Rishi R. Paudal, Giri R Gnawali, Christopher D Spilling, Jean-François Cavalier, Stéphane Canaan, Mickaël Blaise, Laurent Kremer
Journal of Biological Chemistry 293:2755-2769 (2018)10.1074/jbc.RA117.000760
2017
2017
Efficient synthesis of novel dialkyl-3-cyanopropylphosphate derivatives and evaluation of their anticholinesterase activity
Iyadh Aouani, Badreddine Sellami, Karima Lahbib, Jean-François Cavalier, Soufiane Touil
Bioorganic Chemistry 72:301-307 (2017)10.1016/j.bioorg.2017.05.008
2017
Interfacial Properties of N TAIL , an Intrinsically Disordered Protein
Anaïs Benarouche, Johnny Habchi, Alain Cagna, Ofelia Maniti, Agnès P Girard-Egrot, Jean-François Cavalier, Sonia Longhi, Frédéric Carriere
Biophysical Journal 113:2723-2735 (2017)10.1016/j.bpj.2017.10.010
2017
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis
Phuong Chi Nguyen, Vincent Delorme, Anaïs Benarouche, Benjamin Martin, Rishi Paudel, Giri R Gnawali, Abdeldjalil Madani, Rémy N Puppo, Valérie Landry, Laurent Kremer, Priscille Brodin, Christopher D Spilling, Jean-François Cavalier, Stéphane Canaan
Scientific Reports 7:11751 (2017)10.1038/s41598-017-11843-4
2016
2016
Adsorption of gastric lipase onto multicomponent model lipid monolayers with phase separation
Claire Bourlieu, Gilles Paboeuf, Sophie Chever, Stephane Pezennec, Jean-François Cavalier, Fanny Guyomarc'H, Amélie Deglaire, Said Bouhallab, Didier Dupont, Frédéric Carrière, V. Vié
Colloids and Surfaces B: Biointerfaces 143:97-106 (2016)10.1016/j.colsurfb.2016.03.032
2016
Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration
Fanny Lemarie, Jean-François Cavalier, Cyrielle Garcia, F. Boissel, V. Point, Daniel D. Catheline, Philippe P. Legrand, F. Carriere, Vincent V. Rioux
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861:1111-1120 (2016)10.1016/j.bbalip.2016.06.009
2016
Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis
Vanessa Point, Anaïs Benarouche, Julie Zarrillo, Alexandre Guy, Romain Magnez, Laurence Fonseca, Brigitt Raux, Julien Leclaire, Gérard Buono, Frédéric Fotiadu, Thierry Durand, Frédéric Carrière, Carole Vaysse, Leslie Couedelo, Jean-François Cavalier
European Journal of Medicinal Chemistry 123 (2016)10.1016/j.ejmech.2016.08.009
2016
New lipase assay using Pomegranate oil coating in microtiter plates
S Ulker,, C Placidi,, V Point,, Stéphane Canaan, B. Gadenne, Carole Serveau-Avesque, Frédéric Carrière, Jean-François Cavalier
Biochimie 110-118 (2016)
2015
2015
Biochemical characterization of Yarrowia lipolytica LIP8, a secreted lipase with a cleavable C-terminal region
Jannet Kamoun, Mathieu Schué, Wala Messaoud, Justine Baignol, Vanessa Point, Eduardo Mateos-Diaz, Pascal Mansuelle, Youssef Gargouri, Goetz Parsiegla, Jean-François Cavalier, Frédéric Carrière, Ahmed Aloulou
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1851:129-140 (2015)10.1016/j.bbalip.2014.10.012
2014
2014
An interfacial and comparative in vitro study of gastrointestinal lipases and Yarrowia lipolytica LIP2 lipase, a candidate for enzyme replacement therapy
Anaïs Bénarouche, Vanessa Point, Frédéric Carrière, Jean-François Cavalier
Biochimie 102:145-153 (2014)10.1016/j.biochi.2014.03.004
2014
Using the reversible inhibition of gastric lipase by Orlistat for investigating simultaneously lipase adsorption and substrate hydrolysis at the lipid–water interface
Anaïs Bénarouche, Vanessa Point, Frédéric Carrière, Jean-François Cavalier
Biochimie 101:221-231 (2014)10.1016/j.biochi.2014.01.019
2013
2013
Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: a new class of peptide amphiphiles
Antonella Accardo, Marilisa Leone, Diego Tesauro, Rosa Aufiero, Anaïs Bénarouche, Jean-François Cavalier, Sonia Longhi, Frederic Carriere, Filomena Rossi
Molecular BioSystems 9:1401 (2013)10.1039/c3mb25507g
2013
Biochemical and structural characterization of non-glycosylated Yarrowia lipolytica LIP2 lipase
Ahmed Aloulou, Anaïs Bénarouche, Delphine Puccinelli, Silvia Spinelli, Jean-François Cavalier, Christian Cambillau, Frédéric Carrière
European Journal of Lipid Science and Technology 115:429-441 (2013)10.1002/ejlt.201200440
2013
New insights into the pH-dependent interfacial adsorption of dog gastric lipase using the monolayer technique
Anaïs Bénarouche, Vanessa Point, Goetz Parsiegla, Frédéric Carrière, Jean-François Cavalier
Colloids and Surfaces B: Biointerfaces 111:306-312 (2013)10.1016/j.colsurfb.2013.06.025
2013
Effects of the propeptide of group X secreted phospholipase A2 on substrate specificity and interfacial activity on phospholipid monolayers
Vanessa Point, Anaïs Bénarouche, Ikram Jemel, Goetz Parsiegla, Gérard Lambeau, Frédéric Carrière, Jean-François Cavalier
Biochimie 95:51-58 (2013)10.1016/j.biochi.2012.07.023
2013
Enantioselective Inhibition of Microbial Lipolytic Enzymes by Nonracemic Monocyclic Enolphosphonate Analogues of Cyclophostin
Vanessa Point, Raj Malla, Frederic Carrière, Stéphane Canaan, Christopher Spilling, Jean-François Cavalier
Journal of Medicinal Chemistry 56:4393-4401 (2013)10.1021/jm4000787
2012
2012
MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth
Vincent Delorme, Sadia V. Diomandé, Luc Dedieu, Jean-François Cavalier, Fredéric Carrière, Laurent Kremer, Julien Leclaire, Frédéric Fotiadu, Stéphane Canaan
PLoS ONE 7:e46493 (2012)10.1371/journal.pone.0046493
2012
Synthesis and Kinetic Evaluation of Cyclophostin and Cyclipostins Phosphonate Analogs As Selective and Potent Inhibitors of Microbial Lipases
Vanessa Point, Raj Malla, Sadia Diomande, Benjamin Martin, Vincent Delorme, Frederic Carriere, Stephane Canaan, Nigam Rath, Christopher Spilling, Jean-François Cavalier
Journal of Medicinal Chemistry 55:10204-10219 (2012)10.1021/jm301216x
2009
2009
Synthesis, Structure-activity Relationship and In Vitro Evaluation of Coelenterazine and Coelenteramine Derivatives as Inhibitors of Lipid Peroxidation
Maggi Burton, Catherine de Tollenaere, Jean-François Cavalier, Cécile Marchand, Frédérique Dussart, Jacqueline Marchand-Brynaert, Jean-François Rees
Free Radical Research 37:145-158 (2009)10.1080/1071576021000036443
2009
Validation of lipolysis product extraction from aqueous/biological samples, separation and quantification by thin-layer chromatography with flame ionization detection analysis using O-cholesteryl ethylene glycol as a new internal standard
Jean-François Cavalier, Dominique Lafont, Paul Boullanger, David Houisse, Jacqueline Giallo, Jean-Michel Ballester, Frédéric Carrière
Journal of Chromatography A 1216:6543-6548 (2009)10.1016/j.chroma.2009.07.061
2005
2005
Discrimination between closed and open forms of lipases using electrophoretic techniques
Jean-François Cavalier, N. Miled, M. Riviere, J.F. Cavalier, G. Buono, L. Berti, R. Verger
Analytical Biochemistry 338:171-178 (2005)10.1016/j.ab.2004.11.046
2004
2004
2,6-Diamino-3,5-diaryl-1,4-pyrazine Derivatives as Novel Antioxidants
Jean-François Cavalier, Maggi Burton, Catherine de Tollenaere, Frédérique Dussart, Cécile Marchand, Jean-François Rees, Jacqueline Marchand-Brynaert
Synthesis: Journal of Synthetic Organic Chemistry 2001:0768-0772 (2004)10.1055/s-2001-12764
2003
2003
N -(Alkyl)-2-amino-1,4-pyrazine Derivatives: Synthesis and Antioxidative Properties of 3- and 3,5- p -Hydroxyphenyl-Substituted Compounds
Paul Jeanjot, Frédéric Bruyneel, Axelle Arrault, Sonia Gharbi, Jean-François Cavalier, Agnès Abels, Cécile Marchand, Roland Touillaux, Jean-François Rees, Jacqueline Marchand-Brynaert
Synthesis: Journal of Synthetic Organic Chemistry 2003:0513-0522 (2003)10.1055/s-2003-37652
2001
2001
Catechol derivatives of aminopyrazine and cell protection against uvb-induced mortality
Jean-François Cavalier, Maggi Burton, Frédérique Dussart, Cécile Marchand, Jean-François Rees, Jacqueline Marchand-Brynaert
Bioorganic and Medicinal Chemistry Letters 9:1037-1044 (2001)10.1016/s0968-0896(00)00321-7
2000
2000
2000
Covalent Inhibition of Digestive Lipases by Chiral Phosphonates
Jean-François Cavalier, Gerard Buono, Robert Verger
Accounts of Chemical Research 33:579-589 (2000)10.1021/ar990150i
1999
1999
Inhibition of human gastric and pancreatic lipases by chiral alkylphosphonates. A kinetic study with 1,2-didecanoyl-sn-glycerol monolayer
Jean-François Cavalier, Stéphane Ransac, Robert Verger, Gérard Buono
Chemistry and Physics of Lipids 100:3-31 (1999)10.1016/s0009-3084(99)00028-6
1999
Interfacial and/or molecular recognition by lipases of mixed monomolecular films of 1,2-dicaprin and chiral organophosphorus glyceride analogues?
Frank Marguet, Isabelle Douchet, Jean-François Cavalier, Gerard Buono, Robert Verger
Colloids and Surfaces B: Biointerfaces 13:37-45 (1999)10.1016/S0927-7765(98)00099-X
1999
New Synthesis of sn-1,2-and sn-2,3-O-Diacylglycerols ؊ Application to the Synthesis of Enantiopure Phosphonates Analogous to Triglycerides: A New Class of Inhibitors of Lipases
Frank Marguet, Jean-François Cavalier, Robert Verger, Gérard Buono
European Journal of Organic Chemistry (1999)
1998
1998
New Highly Diastereoselective Synthesis of Phosphoramidates. A Route to Chiral Methyl p -Nitrophenyl Alkylphosphonates
Jean-François Cavalier, Frédéric Fotiadu, Robert Verger, Gérard Buono
SYNLETT 1998:73-75 (1998)10.1055/s-1998-1560