Research group: Lipolysis & Bacterial Pathogenicity

Phone: +33 (0)4 91 16 40 93

Room: BM311

Publications

2021

2021
Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis?

Ivy Mallick, Pierre Santucci, Isabelle Poncin, Vanessa Point, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan

FEMS Microbiology Reviews (2021)10.1093/femsre/fuab029

2020

2020
Lipolytic enzymes inhibitors: A new way for antibacterial drugs discovery

Jean-François Cavalier, Christopher Spilling, Thierry Durand, Luc Camoin, Stéphane Canaan

European Journal of Medicinal Chemistry 112908 (2020)10.1016/j.ejmech.2020.112908

2020
Synthesis, antimicrobial activity and molecular docking study of novel α‐(diphenylphosphoryl)‐ and α‐(diphenylphosphorothioyl)cycloalkanone oximes

Nejib Jebli, Selma Hamimed, Kristof van Hecke, Jean-François Cavalier, Soufiane Touil

Chemistry and Biodiversity 17:e2000217 (2020)10.1002/cbdv.202000217

2020
Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus

Abdeldjalil Madani, Ivy Mallick, Alexandre Guy, Céline Crauste, Thierry Durand, Patrick Fourquet, Stéphane Audebert, Luc Camoin, Stéphane Canaan, Jean-François Cavalier

PLoS ONE 15:e0238178 (2020)10.1371/journal.pone.0238178

2019

2019
Design, synthesis, antimicrobial evaluation, and molecular docking studies of novel symmetrical 2,5‐difunctionalized 1,3,4‐oxadiazoles

Shaima Hkiri, Afifa Hafidh, Jean-François Cavalier, Soufiane Touil, Ali Samarat

Journal of Heterocyclic Chemistry (2019)10.1002/jhet.3837

2019
Cyclipostins and Cyclophostin Analogues as Multitarget Inhibitors That Impair Growth of Mycobacterium abscessus

Abdeldjalil Madani, Jeremy Ridenour, Benjamin Martin, Rishi Paudel, Anosha Abdul Basir, Vincent Le Moigne, Jean-Louis Herrmann, Stéphane Audebert, Luc Camoin, Laurent Kremer, Christopher Spilling, Stéphane Canaan, Jean-François Cavalier

ACS Infectious Diseases (2019)10.1021/acsinfecdis.9b00172

2019
Worms’ Antimicrobial Peptides

Bruno Renato, Marc Maresca, Stéphane Canaan, Jean-François Cavalier, Kamel Mabrouk, Céline Boidin-Wichlacz, Hamza Olleik, D. Zeppilli, Priscille Brodin, François Massol, Didier Jollivet, Sacha Jung, Aurélie Tasiemski

Marine drugs 17:512 (2019)10.3390/md17090512

2019
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains

Pierre Santucci, Nabil Smichi, Sadia Diomandé, Isabelle Poncin, Vanessa Point, Hélène Gaussier, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan

FEBS Journal (2019)10.1111/febs.14864

2019
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria

Pierre Santucci, Matt Johansen, Vanessa Point, Isabelle Poncin, Albertus Viljoen, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan

Scientific Reports 9 (2019)10.1038/s41598-019-45164-5

2019
Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria

Pierre Santucci, Christina Dedaki, Alexandros Athanasoulis, Laura Gallorini, Anaïs Munoz, Stéphane Canaan, Jean-François Cavalier, Victoria Magrioti

ChemMedChem 14:349-358 (2019)10.1002/cmdc.201800720

2019
Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility

Dong Yang, Guy Vandenbussche, Didier Vertommen, Damien Evrard, Romany Abskharon, Jean-François Cavalier, Gilles Berger, Stéphane Canaan, Mohammad Shahneawz Khan, Sheng Zeng, Alexandre Wohlkonig, Martine Prévost, Patrice Soumillion, Véronique Fontaine

FEBS Letters (2019)10.1002/1873-3468.13555

2018

2018
Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in Mycobacterium tuberculosis

Phuong Chi Nguyen, van Son Nguyen, Benjamin Martin, Patrick Fourquet, Luc Camoin, Chistopher Spilling, Jean-François Cavalier, Christian Cambillau, Stéphane Canaan

Journal of Molecular Biology 430:5129-5136 (2018)10.1016/j.jmb.2018.09.017

2018
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis

Phuong Chi Nguyen, Vincent Delorme, Anaïs Benarouche, Alexandre Guy, Valérie Landry, Stéphane Audebert, Matthieu Pophillat, Luc Camoin, Céline Crauste, Jean-Marie Galano, Thierry Durand, Priscille Brodin, Stéphane Canaan, Jean-François Cavalier

Bioorganic Chemistry 81:414-424 (2018)10.1016/j.bioorg.2018.08.025

2018
Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases

Phuong Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher Spilling, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan

International Journal of Antimicrobial Agents (2018)10.1016/j.ijantimicag.2017.12.001

2018
The potent effect of mycolactone on lipid membranes

Milène Nitenberg, Anaïs Benarouche, Ofélia Maniti, Estelle Marion, Laurent Marsollier, Julie Géan, Erick Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès Girard-Egrot

PLoS Pathogens 14:e1006814 (e-collection 2018 jan) (2018)10.1371/journal.ppat.1006814

2018
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling

Pierre Santucci, Vanessa Point, Isabelle Poncin, Alexandre Guy, Céline Crauste, Carole Serveau-Avesque, Jean marie Galano, Chistopher d. Spilling, Jean-François Cavalier, Stéphane Canaan

Bioscience Reports 38:BSR20181953 (2018)10.1042/BSR20181953

2018
Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo

Albertus Viljoen, Matthias Richard, Phuong Chi Nguyen, Patrick Fourquet, Luc Camoin, Rishi R. Paudal, Giri Gnawali, Christopher Spilling, Jean-François Cavalier, Stéphane Canaan, Mickaël Blaise, Laurent Kremer

Journal of Biological Chemistry 293:2755-2769 (2018)10.1074/jbc.RA117.000760

2017

2017
Interfacial Properties of N TAIL , an Intrinsically Disordered Protein

Anaïs Benarouche, Johnny Habchi, Alain Cagna, Ofelia Maniti, Agnès Girard-Egrot, Jean-François Cavalier, Sonia Longhi, Frédéric Carriere

Biophysical Journal 113:2723-2735 (2017)10.1016/j.bpj.2017.10.010

2017
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis

Phuong Chi Nguyen, Vincent Delorme, Anaïs Benarouche, Benjamin Martin, Rishi Paudel, Giri Gnawali, Abdeldjalil Madani, Rémy Puppo, Valérie Landry, Laurent Kremer, Priscille Brodin, Christopher Spilling, Jean-François Cavalier, Stéphane Canaan

Scientific Reports 7:11751 (2017)10.1038/s41598-017-11843-4

2016

2016
Adsorption of gastric lipase onto multicomponent model lipid monolayers with phase separation

Claire Bourlieu, Gilles Paboeuf, Sophie Chever, Stephane Pezennec, Jean-François Cavalier, Fanny Guyomarc'H, Amélie Deglaire, Said Bouhallab, Didier Dupont, Frédéric Carrière, V. Vié

Colloids and Surfaces B: Biointerfaces 143:97-106 (2016)10.1016/j.colsurfb.2016.03.032

2016
Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration

Fanny Lemarie, Jean-François Cavalier, Cyrielle Garcia, F. Boissel, V. Point, Daniel Catheline, Philippe Legrand, F. Carriere, Vincent Rioux

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861:1111-1120 (2016)10.1016/j.bbalip.2016.06.009

2016
Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis

Vanessa Point, Anaïs Benarouche, Julie Zarrillo, Alexandre Guy, Romain Magnez, Laurence Fonseca, Brigitt Raux, Julien Leclaire, Gérard Buono, Frédéric Fotiadu, Thierry Durand, Frédéric Carrière, Carole Vaysse, Leslie Couedelo, Jean-François Cavalier

European Journal of Medicinal Chemistry 123 (2016)10.1016/j.ejmech.2016.08.009

2016
New lipase assay using Pomegranate oil coating in microtiter plates

S Ulker,, C Placidi,, V Point,, Stéphane Canaan, B. Gadenne, Carole Serveau-Avesque, Frédéric Carrière, Jean-François Cavalier

Biochimie 110-118 (2016)

2015

2015
Biochemical characterization of Yarrowia lipolytica LIP8, a secreted lipase with a cleavable C-terminal region

Jannet Kamoun, Mathieu Schué, Wala Messaoud, Justine Baignol, Vanessa Point, Eduardo Mateos-Diaz, Pascal Mansuelle, Youssef Gargouri, Goetz Parsiegla, Jean-François Cavalier, Frédéric Carrière, Ahmed Aloulou

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1851:129-140 (2015)10.1016/j.bbalip.2014.10.012

2014

2013

2013
Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: a new class of peptide amphiphiles

Antonella Accardo, Marilisa Leone, Diego Tesauro, Rosa Aufiero, Anaïs Bénarouche, Jean-François Cavalier, Sonia Longhi, Frederic Carriere, Filomena Rossi

Molecular BioSystems 9:1401 (2013)10.1039/c3mb25507g

2013
Biochemical and structural characterization of non-glycosylated Yarrowia lipolytica LIP2 lipase

Ahmed Aloulou, Anaïs Bénarouche, Delphine Puccinelli, Silvia Spinelli, Jean-François Cavalier, Christian Cambillau, Frédéric Carrière

European Journal of Lipid Science and Technology 115:429-441 (2013)10.1002/ejlt.201200440

2013
New insights into the pH-dependent interfacial adsorption of dog gastric lipase using the monolayer technique

Anaïs Bénarouche, Vanessa Point, Goetz Parsiegla, Frédéric Carrière, Jean-François Cavalier

Colloids and Surfaces B: Biointerfaces 111:306-312 (2013)10.1016/j.colsurfb.2013.06.025

2013
Effects of the propeptide of group X secreted phospholipase A2 on substrate specificity and interfacial activity on phospholipid monolayers

Vanessa Point, Anaïs Bénarouche, Ikram Jemel, Goetz Parsiegla, Gérard Lambeau, Frédéric Carrière, Jean-François Cavalier

Biochimie 95:51-58 (2013)10.1016/j.biochi.2012.07.023

2012

2012
MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth

Vincent Delorme, Sadia V. Diomandé, Luc Dedieu, Jean-François Cavalier, Fredéric Carrière, Laurent Kremer, Julien Leclaire, Frédéric Fotiadu, Stéphane Canaan

PLoS ONE 7:e46493 (2012)10.1371/journal.pone.0046493

2009

2009
Synthesis, Structure-activity Relationship and In Vitro Evaluation of Coelenterazine and Coelenteramine Derivatives as Inhibitors of Lipid Peroxidation

Maggi Burton, Catherine de Tollenaere, Jean-François Cavalier, Cécile Marchand, Frédérique Dussart, Jacqueline Marchand-Brynaert, Jean-François Rees

Free Radical Research 37:145-158 (2009)10.1080/1071576021000036443

2009
Validation of lipolysis product extraction from aqueous/biological samples, separation and quantification by thin-layer chromatography with flame ionization detection analysis using O-cholesteryl ethylene glycol as a new internal standard

Jean-François Cavalier, Dominique Lafont, Paul Boullanger, David Houisse, Jacqueline Giallo, Jean-Michel Ballester, Frédéric Carrière

Journal of Chromatography A 1216:6543-6548 (2009)10.1016/j.chroma.2009.07.061

2005

2005
Discrimination between closed and open forms of lipases using electrophoretic techniques

Jean-François Cavalier, N. Miled, M. Riviere, J.F. Cavalier, G. Buono, L. Berti, R. Verger

Analytical Biochemistry 338:171-178 (2005)10.1016/j.ab.2004.11.046

2004

2004
2,6-Diamino-3,5-diaryl-1,4-pyrazine Derivatives as Novel Antioxidants

Jean-François Cavalier, Maggi Burton, Catherine de Tollenaere, Frédérique Dussart, Cécile Marchand, Jean-François Rees, Jacqueline Marchand-Brynaert

SYNTHESIS 2001:0768-0772 (2004)10.1055/s-2001-12764

2003

2003
N -(Alkyl)-2-amino-1,4-pyrazine Derivatives: Synthesis and Antioxidative Properties of 3- and 3,5- p -Hydroxyphenyl-Substituted Compounds

Paul Jeanjot, Frédéric Bruyneel, Axelle Arrault, Sonia Gharbi, Jean-François Cavalier, Agnès Abels, Cécile Marchand, Roland Touillaux, Jean-François Rees, Jacqueline Marchand-Brynaert

SYNTHESIS 2003:0513-0522 (2003)10.1055/s-2003-37652

2001

2001
Catechol derivatives of aminopyrazine and cell protection against uvb-induced mortality

Jean-François Cavalier, Maggi Burton, Frédérique Dussart, Cécile Marchand, Jean-François Rees, Jacqueline Marchand-Brynaert

Bioorganic & Medicinal Chemistry Letters 9:1037-1044 (2001)10.1016/s0968-0896(00)00321-7

2000

2000
Chlorosulfonyl Isocyanate

Jean-François Cavalier

SYNLETT 2000:427 (2000)10.1055/s-2000-6546

2000
Covalent Inhibition of Digestive Lipases by Chiral Phosphonates

Jean-François Cavalier, Gerard Buono, Robert Verger

Accounts of Chemical Research 33:579-589 (2000)10.1021/ar990150i

1999

1999
Inhibition of human gastric and pancreatic lipases by chiral alkylphosphonates. A kinetic study with 1,2-didecanoyl-sn-glycerol monolayer

Jean-François Cavalier, Stéphane Ransac, Robert Verger, Gérard Buono

Chemistry and Physics of Lipids 100:3-31 (1999)10.1016/s0009-3084(99)00028-6

1999
1999
Interfacial and/or molecular recognition by lipases of mixed monomolecular films of 1,2-dicaprin and chiral organophosphorus glyceride analogues?

Frank Marguet, Isabelle Douchet, Jean-François Cavalier, Gerard Buono, Robert Verger

Colloids and Surfaces B: Biointerfaces 13:37-45 (1999)10.1016/S0927-7765(98)00099-X

1998

1998
New Highly Diastereoselective Synthesis of Phosphoramidates. A Route to Chiral Methyl p -Nitrophenyl Alkylphosphonates

Jean-François Cavalier, Frédéric Fotiadu, Robert Verger, Gérard Buono

SYNLETT 1998:73-75 (1998)10.1055/s-1998-1560

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