Pierre Santucci
CRCN CNRS
Publications
2025
2025
A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria
Tonia Dargham, John Jairo Aguilera-Correa, Romain Avellan, Ivy Mallick, Léa Celik, Pierre Santucci, Gael Brasseur, Isabelle Poncin, Vanessa Point, Stéphane Audebert, Luc Camoin, Wassim Daher, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan
mBio 16:e01475-24 (2025)10.1128/mbio.01475-24
2025
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms.
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci
FEBS Letters (2025)10.1002/1873-3468.70023
2024
2024
Host cell environments and antibiotic efficacy in tuberculosis
Nathan J Day, Pierre Santucci, Maximiliano G Gutierrez
Trends in Microbiology 32:270-279 (2024)10.1016/j.tim.2023.08.009
2024
Antitubercular potential and p H ‐driven mode of action of salicylic acid derivatives
Janïs Laudouze, Thomas Francis, Emma Forest, Frédérique Mies, Jean‐michel Bolla, Céline Crauste, Stéphane Canaan, Vadim Shlyonsky, Pierre Santucci, Jean‐françois Cavalier
FEBS Open Bio (2024)10.1002/2211-5463.13944
2024
Fluorescence‐based CRISPR interference system for controlled genetic repression and live single‐cell imaging in mycobacteria
Janïs Laudouze, Vanessa Point, Wafaa Achache, Céline Crauste, Stéphane Canaan, Pierre Santucci
FEBS Letters (2024)10.1002/1873-3468.15071
2024
Molecular Microbiology of Microbiomes
Pierre Santucci
Molecular Microbiology 122:271-272 (2024)10.1111/mmi.15308
2024
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus
Morgane Sarrazin, Isabelle Poncin, Patrick Fourquet, Stéphane Audebert, Luc Camoin, Yann Denis, Pierre Santucci, Christopher D Spilling, Laurent Kremer, Vincent Le Moigne, Jean-Louis Herrmann, Jean-François Cavalier, Stéphane Canaan
Journal of Biomedical Science 31:103 (2024)10.1186/s12929-024-01091-w
2023
2023
Intrabacterial lipid inclusion‐associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis
Tonia Dargham, Ivy Mallick, Laurent Kremer, Pierre Santucci, Stéphane Canaan
FEBS Open Bio 13:2306-2323 (2023)10.1002/2211-5463.13721
2023
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
Enrica Pellegrino, Beren Aylan, Claudio Bussi, Antony Fearns, Elliott Bernard, Natalia Athanasiadi, Pierre Santucci, Laure Botella, Maximiliano Gutierrez
Journal of Cell Biology 222:e202303066 (2023)10.1083/jcb.202303066
2023
Meet early career researcher—Ismath Sadhir—Awardee of the molecular microbiology poster prize at the EMBO workshop bacterial morphogenesis, survival and virulence: Dynamic genomes and envelopes
Pierre Santucci
Molecular Microbiology 120:103-104 (2023)10.1111/mmi.15111
2022
2022
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott Bernard, Nourdine Bah, Mariana Silva dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James Macrae, Maria Greco, Thomas Reinheckel, Matthias Trost, Maximiliano Gutierrez
Nature Communications 13:7338 (2022)10.1038/s41467-022-34632-8
2022
Cell wall architecture and function in microbial physiology
Pierre Santucci
Molecular Microbiology 117:715-716 (2022)10.1111/mmi.14892
2022
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis
Pierre Santucci, Beren Aylan, Laure Botella, Elliott Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano Gutierrez
mBio 13 (2022)10.1128/mbio.00117-22
2021
2021
Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis?
Ivy Mallick, Pierre Santucci, Isabelle Poncin, Vanessa Point, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan
FEMS Microbiology Reviews (2021)10.1093/femsre/fuab029
2021
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
Pierre Santucci, Daniel Greenwood, Antony Fearns, Kai Chen, Haibo Jiang, Maximiliano Gutierrez
Nature Communications 12:3816 (2021)10.1038/s41467-021-24127-3
2021
Intracellular pathogens, membrane damage and cytosolic access
Pierre Santucci
Cellular Microbiology 23 (2021)10.1111/cmi.13296
2020
2020
M. tuberculosis infection of human iPSDM reveals complex membrane dynamics during xenophagy evasion
Elliott Bernard, Antony Fearns, Claudio Bussi, Pierre Santucci, Christopher Peddie, Rachel Lai, Lucy Collinson, Maximiliano Gutierrez
Journal of Cell Science (2020)10.1242/jcs.252973
2019
2019
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains
Pierre Santucci, Nabil Smichi, Sadia Diomandé, Isabelle Poncin, Vanessa Point, Hélène Gaussier, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan
FEBS Journal (2019)10.1111/febs.14864
2019
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria
Pierre Santucci, Matt Johansen, Vanessa Point, Isabelle Poncin, Albertus Viljoen, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan
Scientific Reports 9 (2019)10.1038/s41598-019-45164-5
2019
Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria
Pierre Santucci, Christina Dedaki, Alexandros Athanasoulis, Laura Gallorini, Anaïs Munoz, Stéphane Canaan, Jean-François Cavalier, Victoria Magrioti
ChemMedChem 14:349-358 (2019)10.1002/cmdc.201800720
2018
2018
Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases
Phuong Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher D Spilling, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan
International Journal of Antimicrobial Agents (2018)10.1016/j.ijantimicag.2017.12.001
2018
Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages
Pierre Santucci, Sadia Diomandé, Isabelle Poncin, Laetitia Alibaud, Albertus Viljoen, Laurent Kremer, Chantal de Chastellier, Stéphane Canaan
Infection and Immunity 86 (2018)10.1128/IAI.00394-18
2018
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling
Pierre Santucci, Vanessa Point, Isabelle Poncin, Alexandre Guy, Céline Crauste, Carole Serveau-Avesque, Jean-Marie Galano, Chistopher d. Spilling, Jean-François Cavalier, Stéphane Canaan
Bioscience Reports 38:BSR20181953 (2018)10.1042/BSR20181953
2018
Lipid Droplets Breakdown: Adipose Triglyceride Lipase Leads the Way
Pierre Santucci, Stéphane Canaan
Current Protein and Peptide Science 19:1131-1133 (2018)10.2174/1389203719666180809143000
2016
2016
Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage
Valentina Guerrini, Selvakumar Subbian, Pierre Santucci, Stéphane Canaan, Maria Laura Gennaro, Gianni Pozzi
PLoS ONE 11:e0167989 (2016)10.1371/journal.pone.0167989
2016
Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis
Pierre Santucci, Eerie Bouzid, Nabil Smichi, Isabelle Poncin, Laurent Kremer, Chantal de Chastellier, Michel Drancourt, Stéphane Canaan
Frontiers in Cellular and Infection Microbiology 6:122 (2016)10.3389/fcimb.2016.00122