Research group: Lipolysis & Bacterial Pathogenicity

Phone: +33 (0)4 91 16 40 91

Room: BM309

Publications

2022

2022
Cell wall architecture and function in microbial physiology

Pierre Santucci

Molecular Microbiology 117:715-716 (2022)10.1111/mmi.14892

2022
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis

Pierre Santucci, Beren Aylan, Laure Botella, Elliott Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano Gutierrez

mBio 13 (2022)10.1128/mbio.00117-22

2021

2021
Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis?

Ivy Mallick, Pierre Santucci, Isabelle Poncin, Vanessa Point, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan

FEMS Microbiology Reviews (2021)10.1093/femsre/fuab029

2021
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Pierre Santucci, Daniel Greenwood, Antony Fearns, Kai Chen, Haibo Jiang, Maximiliano Gutierrez

Nature Communications 12:3816 (2021)10.1038/s41467-021-24127-3

2021

2020

2020
M. tuberculosis infection of human iPSDM reveals complex membrane dynamics during xenophagy evasion

Elliott Bernard, Antony Fearns, Claudio Bussi, Pierre Santucci, Christopher Peddie, Rachel Lai, Lucy Collinson, Maximiliano Gutierrez

Journal of Cell Science (2020)10.1242/jcs.252973

2019

2019
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains

Pierre Santucci, Nabil Smichi, Sadia Diomandé, Isabelle Poncin, Vanessa Point, Hélène Gaussier, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan

FEBS Journal (2019)10.1111/febs.14864

2019
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria

Pierre Santucci, Matt Johansen, Vanessa Point, Isabelle Poncin, Albertus Viljoen, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan

Scientific Reports 9 (2019)10.1038/s41598-019-45164-5

2019
Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria

Pierre Santucci, Christina Dedaki, Alexandros Athanasoulis, Laura Gallorini, Anaïs Munoz, Stéphane Canaan, Jean-François Cavalier, Victoria Magrioti

ChemMedChem 14:349-358 (2019)10.1002/cmdc.201800720

2018

2018
Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases

Phuong Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher D Spilling, Laurent Kremer, Jean-François Cavalier, Stéphane Canaan

International Journal of Antimicrobial Agents (2018)10.1016/j.ijantimicag.2017.12.001

2018
Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages

Pierre Santucci, Sadia Diomandé, Isabelle Poncin, Laetitia Alibaud, Albertus Viljoen, Laurent Kremer, Chantal de Chastellier, Stéphane Canaan

Infection and Immunity 86 (2018)10.1128/IAI.00394-18

2018
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling

Pierre Santucci, Vanessa Point, Isabelle Poncin, Alexandre Guy, Céline Crauste, Carole Serveau-Avesque, Jean marie Galano, Chistopher d. Spilling, Jean-François Cavalier, Stéphane Canaan

Bioscience Reports 38:BSR20181953 (2018)10.1042/BSR20181953

2018
Lipid Droplets Breakdown: Adipose Triglyceride Lipase Leads the Way

Pierre Santucci, Stéphane Canaan

Current Protein and Peptide Science 19:1131-1133 (2018)10.2174/1389203719666180809143000

2016

2016
Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage

Valentina Guerrini, Selvakumar Subbian, Pierre Santucci, Stéphane Canaan, Maria Laura Gennaro, Gianni Pozzi

PLoS ONE 11:e0167989 (2016)10.1371/journal.pone.0167989

2016
Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis

Pierre Santucci, Eerie Bouzid, Nabil Smichi, Isabelle Poncin, Laurent Kremer, Chantal de Chastellier, Michel Drancourt, Stéphane Canaan

Frontiers in Cellular and Infection Microbiology 6:122 (2016)10.3389/fcimb.2016.00122

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