Roland Lloubès
DR, CNRS Emeritat
Research group: Molecular transport across the bacterial cell enveloppe
Phone: +33 (0)4 91 16 41 56
Room: BM109
Publications
2025
2025
Cryo-EM structures of the E. coli Ton and Tol motor complexes
Herve Celia, Istvan Botos, Rodolfo Ghirlando, Denis Duché, Bridgette Beach, Roland Lloubes, Susan Buchanan
Nature Communications 16:5506 (2025)10.1038/s41467-025-61286-z
2019
2019
Tol Energy-Driven Localization of Pal and Anchoring to the Peptidoglycan Promote Outer-Membrane Constriction
Melissa Petiti, Bastien Serrano, Laura Faure, Roland Lloubes, Tam Mignot, Denis Duché
Journal of Molecular Biology 431:3275-3288 (2019)10.1016/j.jmb.2019.05.039
2019
Decoupling filamentous phage uptake and energy of the TolQRA motor in Escherichia coli .
Poutoum Samire, Bastien Serrano, Denis Duché, Emeline Lemarie, Roland Lloubes, Laetitia Houot
Journal of Bacteriology (2019)10.1128/JB.00428-19
2017
2017
Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury
Martina Bielaszewska, Christian Rüter, Andreas Bauwens, Lilo Greune, Kevin-André Jarosch, Daniel Steil, Wenlan Zhang, Xiaohua He, Roland Lloubès, Angelika Fruth, Kwang Sik K. S. Kim, Alexander Schmidt, Ulrich Dobrindt, Alexander Mellmann, Helge Karch
PLoS Pathogens 13 (2017)10.1371/journal.ppat.1006159
2017
Electrostatic interactions between the CTX phage minor coat protein and the bacterial host receptor TolA drive the pathogenic conversion of Vibrio cholerae
Laetitia Houot, Romain Navarro, Matthieu Nouailler, Denis Duché, Francoise Guerlesquin, Roland Lloubès
Journal of Biological Chemistry 292:13584-13598 (2017)10.1074/jbc.M117.786061
2016
2016
Structural insight into the role of the Ton complex in energy transduction
Hervé H. Celia, Nicholas Noinaj, Stanislav D Zakharov, Enrica Bordignon, Istvan Botos, Mónica Santamaria, Travis J Barnard, William A Cramer, Roland Lloubès, Susan K Buchanan
Nature 538:60-65 (2016)10.1038/nature19757
2016
(1)H, (15)N and (13)C resonance assignments of the C-terminal domain of Vibrio cholerae TolA protein.
Romain Navarro, Olivier Bornet, Laetitia Houot, Roland Lloubes, Francoise Guerlesquin, Matthieu Nouailler
Biomol NMR Assign (2016)10.1007/s12104-016-9690-y
2015
2015
Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain
Lisa Kunsmann, Christian Rüter, Andreas Bauwens, Lilo Greune, Malte Glüder, Björn Kemper, Angelika Fruth, Sun Nyunt Wai, Xiaohua He, Roland Lloubes, M. Alexander Schmidt, Ulrich Dobrindt, Alexander Mellmann, Helge Karch, Martina Bielaszewska
Scientific Reports 1-18 (2015)10.1038/srep13252
2013
2013
Non classical secretion systems.
Roland Lloubes, Alain Bernadac, Laetitia Houot, Stéphanie Pommier
Res. Microbiol. 164:655-63 (2013)10.1016/j.resmic.2013.03.015
2012
2012
Characterization of colicin M and its orthologs targeting bacterial cell wall peptidoglycan biosynthesis.
Hélène Barreteau, Meriem El Ghachi, Aurélie Barnéoud-Arnoulet, Emmanuelle Sacco, Thierry Touzé, Denis Duché, Fabien Gérard, Mark Brooks, Delphine Patin, Ahmed Bouhss, Didier Blanot, Herman Van Tilbeurgh, Michel Arthur, Roland Lloubes, Dominique Mengin-Lecreulx
Microb. Drug Resist. 18:222-9 (2012)10.1089/mdr.2011.0230
2012
Energetics of colicin import revealed by genetic cross-complementation between the Tol and Ton systems.
Roland Lloubes, Emilie Goemaere, Xiang Y. Zhang, E. Cascales, Denis Duché
Biochem. Soc. Trans. 40:1480-5 (2012)10.1042/BST20120181
2012
Colicin M, a peptidoglycan lipid-II-degrading enzyme: potential use for antibacterial means?
Thierry Touzé, Hélène Barreteau, Meriem El Ghachi, Ahmed Bouhss, Aurélie Barnéoud-Arnoulet, Delphine Patin, Emmanuelle Sacco, Didier Blanot, Michel Arthur, Denis Duché, Roland Lloubes, Dominique Mengin-Lecreulx
Biochem. Soc. Trans. 40:1522-7 (2012)10.1042/BST20120189
2012
The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC.
Abdelrahim Zoued, Roland Lloubes, Laure Journet, E. Cascales, Marie-Stéphanie Aschtgen
MicrobiologyOpen 1:71-82 (2012)10.1002/mbo3.9
2011
2011
Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins.
Christophe S Bernard, Yannick R Brunet, Marthe Gavioli, Roland Lloubes, E. Cascales
Journal of Bacteriology 193:2158-67 (2011)10.1128/JB.00029-11
2011
An epigenetic switch involving overlapping fur and DNA methylation optimizes expression of a type VI secretion gene cluster
Yannick R Brunet, Christophe S Bernard, Marthe Gavioli, Roland Lloubes, E. Cascales
PLoS Genetics 7:e1002205 (2011)10.1371/journal.pgen.1002205
2011
Mapping the interactions between Escherichia coli TolQ transmembrane segments
Xiang Y-Z Zhang, Emilie L Goemaere, Nadir Seddiki, Hervé H. Celia, Marthe Gavioli, E. Cascales, Roland Lloubes
Journal of Biological Chemistry 286:11756-64 (2011)10.1074/jbc.M110.192773
2010
2010
Toxicity of the Colicin M Catalytic Domain Exported to the Periplasm Is FkpA Independent
Aurélie Barnéoud-Arnoulet, Hélène Barreteau, Thierry Touze, Dominique Mengin-Lecreulx, Roland Lloubes, Denis Duché
Journal of Bacteriology 192:5212-5219 (2010)10.1128/JB.00431-10
2010
Deciphering the Catalytic Domain of Colicin M, a Peptidoglycan Lipid II-degrading Enzyme
Hélène Barreteau, Ahmed Bouhss, Fabien Gérard, Denis Duché, Boubekeur Boussaid, Didier Blanot, Roland Lloubes, Dominique Mengin-Lecreulx, Thierry Touze
Journal of Biological Chemistry 285:12378-12389 (2010)10.1074/jbc.M109.093583
2010
Channel Domain of Colicin A Modifies the Dimeric Organization of Its Immunity Protein
Xiang Y-Z Zhang, Roland Lloubes, Denis Duché
Journal of Biological Chemistry 285:38053-38061 (2010)10.1074/jbc.M110.144071
2008
2008
Immunity Protein Protects Colicin E2 from OmpT Protease
Denis Duché, Mohamed Issouf, Roland Lloubes
Journal of Biochemistry 145:95-101 (2008)10.1093/jb/mvn149
2007
2007
Colicin biology.
E. Cascales, Susan Buchanan, Denis Duché, Colin Kleanthous, Roland Lloubes, Kathleen Postle, Margaret Riley, Stephen Slatin, Danièle Cavard
Microbiology and Molecular Biology Reviews 71:158-229 (2007)10.1128/MMBR.00036-06
2006
2006
Release of Immunity Protein Requires Functional Endonuclease Colicin Import Machinery
Denis Duché, Aurélie Frenkian, Valérie Prima, Roland Lloubes
Journal of Bacteriology 188:8593-8600 (2006)10.1128/JB.00941-06
2004
2004
Improved methods for producing outer membrane vesicles in Gram-negative bacteria.
Thomas Henry, Stéphanie Pommier, Laure Journet, Alain Bernadac, Jean-Pierre Gorvel, Roland Lloubès
Research in Microbiology 155:437-46 (2004)10.1016/j.resmic.2004.04.007
2002
2002
Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.
Emmanuelle Bouveret, Laure Journet, Anne Walburger, E. Cascales, Hélène Bénédetti, Roland Lloubes
Biochimie 84:413-21 (2002)
1994
1994
The colicin A pore-forming domain fused to mitochondrial intermembrane space sorting signals can be functionally inserted into the Escherichia coli plasma membrane by a mechanism that bypasses the Tol proteins
David Espesset, Yves Corda, Kyle Cunningham, Hélène Bénédetti, Roland Lloubes, Claude Lazdunski, Vincent Géli
Molecular Microbiology 13:1121-1131 (1994)10.1111/j.1365-2958.1994.tb00503.x