Sophie Bleves
PU, AMU
Research group: Pseudomonas aeruginosa pathogenicityGroup leader
Phone: +33 (0)4 91 16 44 51
Room: BM102
Publications
2025
2025
Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in gram‐negative bacteria
Audrey Goman, Bérengère Ize, Katy Jeannot, Camille Pin, Delphine Payros, Cécile Goursat, Léa Ravon-Katossky, Kazunori Murase, Camille Chagneau, Hélène Revillet, Frédéric Taieb, Sophie Bleves, Laure David, Etienne Meunier, Priscilla Branchu, Eric Oswald
Journal of Extracellular Vesicles 14:e270032 (2025)10.1002/jev2.70032
2022
2022
What Is New in the Anti–Pseudomonas aeruginosa Clinical Development Pipeline Since the 2017 WHO Alert?
Sébastien Reig, Audrey Le Gouellec, Sophie Bleves
Frontiers in Cellular and Infection Microbiology 12 (2022)10.3389/fcimb.2022.909731
2021
2021
Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1 sub-unit
Eliza Ye-Chen Soh, Frances Smith, Maxime Rémi Gimenez, Liang Yang, Rebecca Munk Vejborg, Matthew Fletcher, Nigel Halliday, Sophie Bleves, Stephan Heeb, Miguel Cámara, Michael Givskov, Kim Hardie, Tim Tolker-Nielsen, Bérengère Ize, Paul Williams
PLoS Pathogens 17:e1009425 (2021)10.1371/journal.ppat.1009425
2020
2020
Bacterial injection machines: Evolutionary diverse but functionally convergent
Sophie Bleves, Jorge E Galán, Matxalen Llosa
Cellular Microbiology e13157 (2020)10.1111/cmi.13157
2020
Editorial: Protein Export and Secretion Among Bacterial Pathogens
Thibault G Sana, Romé Voulhoux, Denise M Monack, Bérengère Ize, Sophie Bleves
Frontiers in Cellular and Infection Microbiology 9 (2020)10.3389/fcimb.2019.00473
2019
2019
A Type VI Secretion System trans- kingdom effector is required for the delivery of a novel antibacterial toxin in Pseudomonas aeruginosa
Benjamin Berni, Chantal Soscia, Sarah Djermoun, Bérengère Ize, Sophie Bleves
Frontiers in Microbiology (2019)10.3389/fmicb.2019.01218
2019
Killing from the inside: Intracellular role of T3SS in the fate of Pseudomonas aeruginosa within macrophages revealed by mgtC and oprF mutants
Preeti Garai, Laurence Berry, Malika Moussouni, Sophie Bleves, Anne-Béatrice Blanc-Potard
PLoS Pathogens 15:e1007812 (2019)10.1371/journal.ppat.1007812
2019
Differential modulation of Quorum-Sensing signaling through QslA in Pseudomonas
Thibault Gery Sana, Rodrigo Lomas, Maxime Rémi Gimenez, Aurélie Laubier, Chantal Soscia, Claire Chauvet, Ana Conesa, Romé Voulhoux, Bérengère Ize, Sophie Bleves
Journal of Bacteriology (2019)
2018
2018
United we stand, divided we fall
Sophie Bleves, Benjamin Berni
Nature Microbiology (2018)10.1038/s41564-018-0130-x
2018
Genome wide identification and experimental validation of Pseudomonas aeruginosa Tat substrates
Maxime Rémi Gimenez, Govind Chandra, Perrine van Overvelt, Romé Voulhoux, Sophie Bleves, Bérengère Ize
Scientific Reports 8:11950 (2018)10.1038/s41598-018-30393-x
2017
2017
Don't judge a book by its cover: The Hcps are not only structural components of the T6SS machinery
Sophie Bleves
Virulence 8:1053-1054 (2017)10.1080/21505594.2017.1295908
2017
Pseudomonas aeruginosa zinc uptake in chelating environment is primarily mediated by the metallophore pseudopaline
Sebastien Lhospice, Nicolas Oswaldo Gomez, Laurent Ouerdane, Catherine Brutesco, Ghassan Ghssein, Christine Hajjar, Ahmed Liratni, Shuanglong Wang, Pierre Richaud, Sophie Bleves, Geneviève Ball, Elise Borezée-Durant, Ryszard Lobinski, David Pignol, Pascal Arnoux, Romé Voulhoux
Scientific Reports 7:1-10 (2017)10.1038/s41598-017-16765-9
2016
2016
Game of Trans-Kingdom Effectors
Sophie Bleves
Trends in Microbiology 24:773-774 (2016)10.1016/j.tim.2016.08.002
2016
Structural Basis of Lipid Targeting and Destruction by the Type V Secretion System of Pseudomonas aeruginosa.
Paulo Vinicius da Mata Madeira, Samira Zouhir, Pauline Basso, David Neves, Aurélie Laubier, Richard Salacha, Sophie Bleves, Eric Faudry, Carlos Contreras-Martel, Andréa Dessen
Journal of Molecular Biology 428:1790-803 (2016)10.1016/j.jmb.2016.03.012
2016
The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting.
Thibault G Sana, Benjamin Berni, Sophie Bleves
Frontiers in Cellular and Infection Microbiology 6:61 (2016)10.3389/fcimb.2016.00061
2015
2015
A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens
Claudine Belon, Chantal Soscia, Audrey Bernut, Aurélie Laubier, Sophie Bleves, Anne-Béatrice Blanc-Potard
PLoS Pathogens 11:e1004969 (2015)10.1371/journal.ppat.1004969
2015
Intracellular phase for an extracellular bacterial pathogen: MgtC shows the way
Audrey Bernut, Claudine Belon, Chantal Soscia, Sophie Bleves, Anne-Béatrice Blanc-Potard
Microbial Cell 2:353-355 (2015)10.15698/mic2015.09.227
2015
Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network
Thibault G. Sana, Christoph Baumann, Andreas Merdes, Chantal Soscia, Thomas Rattei, Abderrahman Hachani, Cerith Jones, Keiryn L. Bennett, Alain Filloux, Giulio Superti-Furga, Romé Voulhoux, Sophie Bleves
mBio 6 (2015)10.1128/mbio.00712-15
2015
Genome-wide Screen of Pseudomonas aeruginosa in Saccharomyces cerevisiae Identifies New Virulence Factors.
Rafat Zrieq, Thibault G Sana, Sandra Vergin, Steve Garvis, Irina Volfson, Sophie Bleves, Romé Voulhoux, Johannes H Hegemann
Frontiers in Cellular and Infection Microbiology 5:81 (2015)10.3389/fcimb.2015.00081
2014
2014
HoPaCI-DB: host-Pseudomonas and Coxiella interaction database.
Sophie Bleves, Irmtraud Dunger, Mathias C Walter, Dimitrios Frangoulidis, Gabi Kastenmüller, Romé Voulhoux, Andreas Ruepp
Nucleic Acids Research 42:D671-6 (2014)10.1093/nar/gkt925
2014
The target cell genus does not matter.
Sophie Bleves, Thibault G Sana, Romé Voulhoux
Trends Microbiol. 22:304-6 (2014)10.1016/j.tim.2014.04.011
2014
Gene transfer: conjugation.
Thibault G Sana, Aurélie Laubier, Sophie Bleves
Methods in Molecular Biology 1149:17-22 (2014)10.1007/978-1-4939-0473-0_3
2013
2013
Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa
Thibault G Sana, Chantal Soscia, Céline M Tonglet, Steve Garvis, Sophie Bleves
PLoS ONE 8:e76030 (2013)10.1371/journal.pone.0076030
2012
2012
The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells.
Thibault G Sana, Abderrahman Hachani, Iwona Bucior, Chantal Soscia, Steve Garvis, Elise Termine, Joanne Engel, Alain Filloux, Sophie Bleves
Journal of Biological Chemistry 287:27095-105 (2012)10.1074/jbc.M112.376368
2011
2011
Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins.
Abderrahman Hachani, Nadine S Lossi, Alexander Hamilton, Cerith Jones, Sophie Bleves, David Albesa-Jové, Alain Filloux
Journal of Biological Chemistry 286:12317-27 (2011)10.1074/jbc.M110.193045
2011
Role of fimV in type II secretion system-dependent protein secretion of Pseudomonas aeruginosa on solid medium.
Gérard P F Michel, Anthony Aguzzi, Geneviève Ball, Chantal Soscia, Sophie Bleves, Romé Voulhoux
Microbiology (Reading, Engl.) 157:1945-54 (2011)10.1099/mic.0.045849-0
2010
2010
The Pseudomonas aeruginosa patatin-like protein PlpD is the archetype of a novel Type V secretion system
R. Salacha, F. Kovacic, Céline Brochier-Armanet, S. Wilhelm, J. Tommassen, A. Filloux, R. Voulhoux, Sophie Bleves
Environmental Microbiology 12:1498-512 (2010)10.1111/j.1462-2920.2010.02174.x
2006
2006
Multiple sensors control reciprocal expression of Pseudomonas aeruginosa ezgulatory RNA and virulence genes.
Isabelle Ventre, Al Goodman, Isabelle Vallet-Gely, Perrine Vasseur, Chantal Soscia, Sören Molin, Sophie Bleves, Andrée Lazdunski, Steve Lory, Alain Filloux
Proceedings of the National Academy of Sciences of the United States of America 103:171-176 (2006)
1999
1999
Assembly of XcpR in the Cytoplasmic Membrane Is Required for Extracellular Protein Secretion in Pseudomonas aeruginosa
Genevieve Ball, Virginie Chapon, Sophie Bleves, Gérard Michel, Marc Bally
Journal of Bacteriology 181:382-388 (1999)