Our concern is to fight against pathogenic mycobacteria by studying lipid metabolism: identification / validation of proteins involved in lipid processes, discovery of new antimycobacterials (synthetic molecules, peptides) targeting lipid biosynthesis, and set up diagnostic tests related to lipid metabolism.
We aim at deciphering the physiological role of lipolytic enzymes involved in lipid metabolism in pathogenic mycobacteria (such as Mycobacterium tuberculosis, M. abscessus, M. marinum, M. ulcerans), their regulation during the infection process and their impact in dormancy phase. As lipid metabolism is directly related to the viability and virulence of mycobacteria, we also develop specific models to study these enzymes and their inhibitors in order to regulate this metabolic pathway and therefore the spread of the disease.
We have established that these enzymes are involved in bacterial growth, virulence (reactivation and propagation), dormancy, lipid storage and degradation as well as in cell wall biosynthesis.
Moreover, our work leads to the discovery of two new families of lipolytic enzyme inhibitors with strong anti-tuberculous effects, which are useful probes to study mycobacterial lipid metabolism, thus opening a new way to fight the disease.
The team’s expertise range from protein biochemistry (purification, biochemical characterization, expression of recombinant protein using E. coli, M. smegmatis, P. Pastoris or baculovirus expression systems), molecular and cell biology (construction of mutant strains, cell infection), lipid analysis to medicinal chemistry (organic synthesis, in silico docking, enzymology, susceptibility testing…) and cell imaging (fluorescence and electron microscopy).
For more details, please visit us at LBPTeam
Members
Publications
2023
Evaluation of the Efficiency of Random and Diblock Methacrylate-Based Amphiphilic Cationic Polymers against Major Bacterial Pathogens Associated with Cystic Fibrosis
Magali Casanova, Hamza Olleik, Slim Hdiouech, Clarisse Roblin, Jean-François Cavalier, Vanessa Point, Katy Jeannot, Baptiste Caron, Josette Perrier, Siméon Charriau, Mickael Lafond, Yohann Guillaneuf, Stéphane Canaan, Catherine Lefay, Marc Maresca
Antibiotics 12:120 (2023)10.3390/antibiotics12010120
2022
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis
Sarah Barelier, Romain Avellan, Giri Raj Gnawali, Patrick Fourquet, Véronique Roig-Zamboni, Isabelle Poncin, Vanessa Point, Yves Bourne, Stéphane Audebert, Luc Camoin, Christopher Spilling, Stéphane Canaan, Jean‐françois Cavalier, Gerlind Sulzenbacher
FEBS Journal (2022)10.1111/febs.16645
2022
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott Bernard, Nourdine Bah, Mariana Silva dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James Macrae, Maria Greco, Thomas Reinheckel, Matthias Trost, Maximiliano Gutierrez
Nature Communications 13:7338 (2022)10.1038/s41467-022-34632-8
2022
Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2
Laura Caccialupi da Prato, Ugo Zayan, Dina Abdallah, Vanessa Point, Fabienne Schaller, Emilie Pallesi-Pocachard, Aurélie Montheil, Stéphane Canaan, Jean-Luc Gaiarsa, Françoise Muscatelli, Valéry Matarazzo
Neuropsychopharmacology (2022)10.1038/s41386-022-01313-5
2022
Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives
Vasiliki Mavrikaki, Alexandros Pagonis, Isabelle Poncin, Ivy Mallick, Stéphane Canaan, Victoria Magrioti, Jean-François Cavalier
Bioorganic & Medicinal Chemistry Letters 64:128692 (2022)10.1016/j.bmcl.2022.128692
2022
Synthesis and Biological Characterization of Fluorescent Cyclipostins and Cyclophostin Analogues: New Insights for the Diagnosis of Mycobacterial-Related Diseases
Morgane Sarrazin, Benjamin Martin, Romain Avellan, Giri Raj Gnawali, Isabelle Poncin, Hugo Le Guenno, Christopher Spilling, Jean-François Cavalier, Stéphane Canaan
ACS Infectious Diseases (2022)10.1021/acsinfecdis.2c00448
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis Adamopoulos, Khosrow Adeli, Timon Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat Aggarwal, Maria Agnello, Patrizia Agostinis, Javed Agrewala, Alexander Agrotis, Patricia Aguilar, S. Tariq Ahmad, Zubair Ahmed, Ulises Ahumada-Castro, Sonja Aits, Shu Aizawa, Yunus Akkoc, Tonia Akoumianaki, Hafize Aysin Akpinar, Ahmed Al-Abd, Lina Al-Akra, Abeer Al-Gharaibeh, Moulay Alaoui-Jamali, Simon Alberti, Elísabet Alcocer-Gómez, Cristiano Alessandri, Muhammad Ali, M. Abdul Alim Al-Bari, Saeb Aliwaini, Javad Alizadeh, Eugènia Almacellas, Alexandru Almasan, Alicia Alonso, Guillermo Alonso, Nihal Altan-Bonnet, Dario Altieri, Élida Álvarez, Sara Alves, Cristine Alves da Costa, Mazen Alzaharna, Marialaura Amadio, Consuelo Amantini, Cristina Amaral, Susanna Ambrosio, Amal Amer, Veena Ammanathan, Zhenyi An, Stig Andersen, Shaida Andrabi, Magaiver Andrade-Silva, Allen Andres, Sabrina Angelini, David Ann, Uche Anozie, Mohammad Ansari, Pedro Antas, Adam Antebi, Zuriñe Antón, Tahira Anwar, Lionel Apetoh, Nadezda Apostolova, Toshiyuki Araki, Yasuhiro Araki, Kohei Arasaki, Wagner Araújo, Jun Araya, Catherine Arden, Maria-Angeles Arévalo, Sandro Arguelles, Esperanza Arias, Jyothi Arikkath, Hirokazu Arimoto, Aileen Ariosa, Darius Armstrong-James, Laetitia Arnauné-Pelloquin, Angeles Aroca, Daniela Arroyo, Ivica Arsov, Rubén Artero, Dalia Maria Lucia Asaro, Michael Aschner, Milad Ashrafizadeh, Osnat Ashur-Fabian, Atanas Atanasov, Alicia Au, Patrick Auberger, Holger Auner, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Yenniffer Ávalos, Sanja Aveic, Célia Alexandra Aveleira, Tamar Avin-Wittenberg, Yucel Aydin, Scott Ayton, Srinivas Ayyadevara, Maria Azzopardi, Misuzu Baba, Jonathan Backer, Steven Backues, Dong-Hun Bae, Ok-Nam Bae, Soo Han Bae, Eric Baehrecke, Ahruem Baek, Seung-Hoon Baek, Sung Hee Baek, Giacinto Bagetta, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xiyuan Bai, Yidong Bai, Nandadulal Bairagi, Shounak Baksi, Teresa Balbi, Cosima Baldari, Walter Balduini, Andrea Ballabio, Maria Ballester, Salma Balazadeh, Rena Balzan, Rina Bandopadhyay, Sreeparna Banerjee, Sulagna Banerjee, Ágnes Bánréti, Yan Bao, Mauricio Baptista, Alessandra Baracca, Cristiana Barbati, Ariadna Bargiela, Daniela Barilà, Peter Barlow, Sami Barmada, Esther Barreiro, George Barreto, Jiri Bartek, Bonnie Bartel, Alberto Bartolome, Gaurav Barve, Suresh Basagoudanavar, Diane Bassham, Robert Bast, Alakananda Basu, Henri Batoko, Isabella Batten, Etienne Baulieu, Bradley Baumgarner, Jagadeesh Bayry, Rupert Beale, Isabelle Beau, Florian Beaumatin, Luiz R.G. Bechara, George Beck, Michael Beers, Jakob Begun, Christian Behrends, Georg M.N. Behrens, Roberto Bei, Eloy Bejarano, Shai Bel, Christian Behl, Amine Belaid, Naïma Belgareh-Touzé, Cristina Bellarosa, Francesca Belleudi, Melissa Belló Pérez, Raquel Bello-Morales, Jackeline Soares de Oliveira Beltran, Sebastián Beltran, Doris Mangiaracina Benbrook, Mykolas Bendorius, Bruno Benitez, Irene Benito-Cuesta, Julien Bensalem, Martin Berchtold, Sabina Berezowska, Daniele Bergamaschi, Matteo Bergami, Andreas Bergmann, Laura Berliocchi, Clarisse Berlioz-Torrent, Amélie Bernard, Lionel Berthoux, Cagri Besirli, Sébastien Besteiro, Virginie Betin, Rudi Beyaert, Jelena Bezbradica, Kiran Bhaskar, Ingrid Bhatia-Kissova, Resham Bhattacharya, Sujoy Bhattacharya, Shalmoli Bhattacharyya, Md. Shenuarin Bhuiyan, Sujit Kumar Bhutia, Lanrong Bi, Xiaolin Bi, Trevor Biden, Krikor Bijian, Viktor Billes, Nadine Binart, Claudia Bincoletto, Asa Birgisdottir, Geir Bjorkoy, Gonzalo Blanco, Ana Blas-Garcia, Janusz Blasiak, Robert Blomgran, Klas Blomgren, Janice Blum, Emilio Boada-Romero, Mirta Boban, Kathleen Boesze-Battaglia, Philippe Boeuf, Barry Boland, Pascale Bomont, Paolo Bonaldo, Srinivasa Reddy Bonam, Laura Bonfili, Juan Bonifacino, Brian Boone, Martin Bootman, Matteo Bordi, Christoph Borner, Beat Bornhauser, Gautam Borthakur, Jürgen Bosch, Santanu Bose, Luis Botana, Juan Botas, Chantal Boulanger, Michael Boulton, Mathieu Bourdenx, Benjamin Bourgeois, Nollaig Bourke, Guilhem Bousquet, Patricia Boya, Peter Bozhkov, Luiz Bozi, Tolga Bozkurt, Doug Brackney, Christian Brandts, Ralf Braun, Gerhard Braus, Roberto Bravo-Sagua, José M. Bravo-San Pedro, Patrick Brest, Marie-Agnès Bringer, Alfredo Briones-Herrera, V. Courtney Broaddus, Peter Brodersen, Jeffrey Brodsky, Steven Brody, Paola Bronson, Jeff Bronstein, Carolyn Brown, Rhoderick Brown, Patricia Brum, John Brumell, Nicola Brunetti-Pierri, Daniele Bruno, Robert Bryson-Richardson, Cecilia Bucci, Carmen Buchrieser, Marta Bueno, Laura Elisa Buitrago-Molina, Simone Buraschi, Shilpa Buch, J. Ross Buchan, Erin Buckingham, Hikmet Budak, Mauricio Budini, Geert Bultynck, Florin Burada, Joseph Burgoyne, M. Isabel Burón, Victor Bustos, Sabrina Büttner, Elena Butturini, Aaron Byrd, Isabel Cabas, Sandra Cabrera-Benitez, Ken Cadwell, Jingjing Cai, Lu Cai, Qian Cai, Montserrat Cairó, Jose Calbet, Guy Caldwell, Kim Caldwell, Jarrod Call, Riccardo Calvani, Ana Calvo, Miguel Calvo-Rubio Barrera, Niels Os Camara, Jacques H. Camonis, Nadine Camougrand, Michelangelo Campanella, Edward Campbell, François-Xavier Campbell-Valois, Silvia Campello, Ilaria Campesi, Juliane Campos, Olivier Camuzard, Jorge Cancino, Danilo Candido de Almeida, Laura Canesi, Isabella Caniggia, Barbara Canonico, Carles Cantí, Bin Cao, Michele Caraglia, Beatriz Caramés, Evie Carchman, Elena Cardenal-Muñoz, Cesar Cardenas, Luis Cardenas, Sandra Cardoso, Jennifer Carew, Georges F. Carle, Gillian Carleton, Silvia Carloni, Didac Carmona-Gutierrez, Leticia Carneiro, Oliana Carnevali, Julian Carosi, Serena Carra, Alice Carrier, Lucie Carrier, Bernadette Carroll, A. Brent Carter, Andreia Neves Carvalho, Magali Casanova, Caty Casas, Josefina Casas, Chiara Cassioli, Eliseo Castillo, Karen Castillo, Sonia Castillo-Lluva, Francesca Castoldi, Marco Castori, Ariel Castro, Margarida Castro-Caldas, Javier Castro-Hernandez, Susana Castro-Obregon, Sergio Catz, Claudia Cavadas, Federica Cavaliere, Gabriella Cavallini, Maria Cavinato, Maria Cayuela, Paula Cebollada Rica, Valentina Cecarini, Francesco Cecconi, Marzanna Cechowska-Pasko, Simone Cenci, Victòria Ceperuelo-Mallafré, João Cerqueira, Janete Cerutti, Davide Cervia, Vildan Bozok Cetintas, Silvia Cetrullo, Han-Jung Chae, Andrei Chagin, Chee-Yin Chai, Gopal Chakrabarti, Oishee Chakrabarti, Tapas Chakraborty, Trinad Chakraborty, Mounia Chami, Georgios Chamilos, David Chan, Edmond Chan, Edward Chan, H.Y. Edwin Chan, Helen Chan, Hung Chan, Matthew T.V. Chan, Yau Sang Chan, Partha Chandra, Chih-Peng Chang, Chunmei Chang, Hao-Chun Chang, Kai Chang, Jie Chao, Tracey Chapman, Nicolas Charlet-Berguerand, Samrat Chatterjee, Shail Chaube, Anu Chaudhary, Santosh Chauhan, Edward Chaum, Frédéric Checler, Michael Cheetham, Chang-Shi Chen, Guang-Chao Chen, Jian-Fu Chen, Liam Chen, Leilei Chen, Lin Chen, Mingliang Chen, Mu-Kuan Chen, Ning Chen, Quan Chen, Ruey-Hwa Chen, Shi Chen, Wei Chen, Weiqiang Chen, Xin-Ming Chen, Xiong-Wen Chen, Xu Chen, Yan Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, Yu-Jen Chen, Yue-Qin Chen, Zhefan Stephen Chen, Zhi Chen, Zhi-Hua Chen, Zhijian Chen, Zhixiang Chen, Hanhua Cheng, Jun Cheng, Shi-Yuan Cheng, Wei Cheng, Xiaodong Cheng, Xiu-Tang Cheng, Yiyun Cheng, Zhiyong Cheng, Zhong Chen, Heesun Cheong, Jit Kong Cheong, Boris Chernyak, Sara Cherry, Chi Fai Randy Cheung, Chun Hei Antonio Cheung, King-Ho Cheung, Eric Chevet, Richard Chi, Alan Kwok Shing Chiang, Ferdinando Chiaradonna, Roberto Chiarelli, Mario Chiariello, Nathalia Chica, Susanna Chiocca, Mario Chiong, Shih-Hwa Chiou, Abhilash Chiramel, Valerio Chiurchiù, Dong-Hyung Cho, Seong-Kyu Choe, Augustine M.K. Choi, Mary Choi, Kamalika Roy Choudhury, Norman Chow, Charleen Chu, Jason Chua, John Jia En Chua, Hyewon Chung, Kin Pan Chung, Seockhoon Chung, So-Hyang Chung, Yuen-Li Chung, Valentina Cianfanelli, Iwona Ciechomska, Mariana Cifuentes, Laura Cinque, Sebahattin Cirak, Mara Cirone, Michael Clague, Robert Clarke, Emilio Clementi, Eliana Coccia, Patrice Codogno, Ehud Cohen, Mickael M. Cohen, Tania Colasanti, Fiorella Colasuonno, Robert Colbert, Anna Colell, Miodrag Čolić, Nuria Coll, Mark Collins, María Colombo, Daniel Colón-Ramos, Lydie Combaret, Sergio Comincini, Márcia Cominetti, Antonella Consiglio, Andrea Conte, Fabrizio Conti, Viorica Raluca Contu, Mark Cookson, Kevin Coombs, Isabelle Coppens, Maria Tiziana Corasaniti, Dale Corkery, Nils Cordes, Katia Cortese, Maria Do Carmo Costa, Sarah Costantino, Paola Costelli, Ana Coto-Montes, Peter Crack, Jose Crespo, Alfredo Criollo, Valeria Crippa, Riccardo Cristofani, Tamas Csizmadia, Antonio Cuadrado, Bing Cui, Jun Cui, Yixian Cui, Yong Cui, Emmanuel Culetto, Andrea Cumino, Andrey Cybulsky, Mark Czaja, Stanislaw Czuczwar, Stefania D’adamo, Marcello D’amelio, Daniela D’arcangelo, Andrew D’lugos, Gabriella D’orazi, James da Silva, Hormos Salimi Dafsari, Ruben Dagda, Yasin Dagdas, Maria Daglia, Xiaoxia Dai, Yun Dai, Yuyuan Dai, Jessica Dal Col, Paul Dalhaimer, Luisa Dalla Valle, Tobias Dallenga, Guillaume Dalmasso, Markus Damme, Ilaria Dando, Nico Dantuma, April Darling, Hiranmoy Das, Srinivasan Dasarathy, Santosh Dasari, Srikanta Dash, Oliver Daumke, Adrian Dauphinee, Jeffrey Davies, Valeria Dávila, Roger Davis, Tanja Davis, Sharadha Dayalan Naidu, Francesca de Amicis, Karolien de Bosscher, Francesca de Felice, Lucia de Franceschi, Chiara de Leonibus, Mayara de Mattos Barbosa, Guido R.Y. de Meyer, Angelo de Milito, Cosimo de Nunzio, Clara de Palma, Mauro de Santi, Claudio de Virgilio, Daniela de Zio, Jayanta Debnath, Brian Debosch, Jean-Paul Decuypere, Mark Deehan, Gianluca Deflorian, James Degregori, Benjamin Dehay, Gabriel del Rio, Joe Delaney, Lea Delbridge, Elizabeth Delorme-Axford, M. Victoria Delpino, Francesca Demarchi, Vilma Dembitz, Nicholas Demers, Hongbin Deng, Zhiqiang Deng, Joern Dengjel, Paul Dent, Donna Denton, Melvin Depamphilis, Channing Der, Vojo Deretic, Albert Descoteaux, Laura Devis, Sushil Devkota, Olivier Devuyst, Grant Dewson, Mahendiran Dharmasivam, Rohan Dhiman, Diego Di Bernardo, Manlio Di Cristina, Fabio Di Domenico, Pietro Di Fazio, Alessio Di Fonzo, Giovanni Di Guardo, Gianni Di Guglielmo, Luca Di Leo, Chiara Di Malta, Alessia Di Nardo, Martina Di Rienzo, Federica Di Sano, George Diallinas, Jiajie Diao, Guillermo Diaz-Araya, Inés Díaz-Laviada, Jared Dickinson, Marc Diederich, Mélanie Dieudé, Ivan Dikic, Shiping Ding, Wen-Xing Ding, Luciana Dini, Jelena Dinić, Miroslav Dinic, Albena Dinkova-Kostova, Marc Dionne, Jörg H.W. Distler, Abhinav Diwan, Ian M.C. Dixon, Mojgan Djavaheri-Mergny, Ina Dobrinski, Oxana Dobrovinskaya, Radek Dobrowolski, Renwick C.J. Dobson, Jelena Đokić, Serap Dokmeci Emre, Massimo Donadelli, Bo Dong, Xiaonan Dong, Zhiwu Dong, Gerald 2nd Dorn, Volker Dotsch, Huan Dou, Juan Dou, Moataz Dowaidar, Sami Dridi, Liat Drucker, Ailian Du, Caigan Du, Guangwei Du, Hai-Ning Du, Li-Lin Du, André Du Toit, Shao-Bin Duan, Xiaoqiong Duan, Sónia Duarte, Anna Dubrovska, Elaine Dunlop, Nicolas Dupont, Raúl Durán, Bilikere Dwarakanath, Sergey Dyshlovoy, Darius Ebrahimi-Fakhari, Leopold Eckhart, Charles Edelstein, Thomas Efferth, Eftekhar Eftekharpour, Ludwig Eichinger, Nabil Eid, Tobias Eisenberg, N. Tony Eissa, Sanaa Eissa, Miriam Ejarque, Abdeljabar El Andaloussi, Nazira El-Hage, Shahenda El-Naggar, Anna Maria Eleuteri, Eman El-Shafey, Mohamed Elgendy, Aristides Eliopoulos, María Elizalde, Philip Elks, Hans-Peter Elsasser, Eslam Elsherbiny, Brooke Emerling, N. Emre, Christina Eng, Nikolai Engedal, Anna-Mart Engelbrecht, Agnete S.T. Engelsen, Jorrit Enserink, Ricardo Escalante, Audrey Esclatine, Mafalda Escobar-Henriques, Eeva-Liisa Eskelinen, Lucile Espert, Makandjou-Ola Eusebio, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Francesco Facchiano, Bengt Fadeel, Claudio Fader, Alex Faesen, W. Douglas Fairlie, Alberto Falcó, Bjorn Falkenburger, Daping Fan, Jie Fan, Yanbo Fan, Evandro Fang, Yanshan Fang, Yognqi Fang, Manolis Fanto, Tamar Farfel-Becker, Mathias Faure, Gholamreza Fazeli, Anthony Fedele, Arthur Feldman, Du Feng, Jiachun Feng, Lifeng Feng, Yibin Feng, Yuchen Feng, Wei Feng, Thais Fenz Araujo, Thomas Ferguson, Álvaro Fernández, Jose Fernandez-Checa, Sonia Fernández-Veledo, Alisdair Fernie, Anthony Ferrante, Alessandra Ferraresi, Merari Ferrari, Julio C.B. Ferreira, Susan Ferro-Novick, Antonio Figueras, Riccardo Filadi, Nicoletta Filigheddu, Eduardo Filippi-Chiela, Giuseppe Filomeni, Gian Maria Fimia, Vittorio Fineschi, Francesca Finetti, Steven Finkbeiner, Edward Fisher, Paul Fisher, Flavio Flamigni, Steven Fliesler, Trude Flo, Ida Florance, Oliver Florey, Tullio Florio, Erika Fodor, Carlo Follo, Edward Fon, Antonella Forlino, Francesco Fornai, Paola Fortini, Anna Fracassi, Alessandro Fraldi, Brunella Franco, Rodrigo Franco, Flavia Franconi, Lisa Frankel, Scott Friedman, Leopold Fröhlich, Gema Frühbeck, Jose Fuentes, Yukio Fujiki, Naonobu Fujita, Yuuki Fujiwara, Mitsunori Fukuda, Simone Fulda, Luc Furic, Norihiko Furuya, Carmela Fusco, Michaela Gack, Lidia Gaffke, Sehamuddin Galadari, Alessia Galasso, Maria Galindo, Sachith Gallolu Kankanamalage, Lorenzo Galluzzi, Vincent Galy, Noor Gammoh, Boyi Gan, Ian Ganley, Feng Gao, Hui Gao, Minghui Gao, Ping Gao, Shou-Jiang Gao, Wentao Gao, Xiaobo Gao, Ana Garcera, Maria Noé Garcia, Verónica Garcia, Francisco García-del Portillo, Vega Garcia-Escudero, Aracely Garcia-Garcia, Marina Garcia-Macia, Diana García-Moreno, Carmen Garcia-Ruiz, Patricia García-Sanz, Abhishek Garg, Ricardo Gargini, Tina Garofalo, Robert Garry, Nils Gassen, Damian Gatica, Liang Ge, Wanzhong Ge, Ruth Geiss-Friedlander, Cecilia Gelfi, Pascal Genschik, Ian Gentle, Valeria Gerbino, Christoph Gerhardt, Kyla Germain, Marc Germain, David Gewirtz, Elham Ghasemipour Afshar, Saeid Ghavami, Alessandra Ghigo, Manosij Ghosh, Georgios Giamas, Claudia Giampietri, Alexandra Giatromanolaki, Gary Gibson, Spencer Gibson, Vanessa Ginet, Edward Giniger, Carlotta Giorgi, Henrique Girao, Stephen Girardin, Mridhula Giridharan, Sandy Giuliano, Cecilia Giulivi, Sylvie Giuriato, Julien Giustiniani, Alexander Gluschko, Veit Goder, Alexander Goginashvili, Jakub Golab, David Goldstone, Anna Golebiewska, Luciana Gomes, Rodrigo Gomez, Rubén Gómez-Sánchez, Maria Catalina Gomez-Puerto, Raquel Gomez-Sintes, Qingqiu Gong, Felix Goni, Javier González-Gallego, Tomas Gonzalez-Hernandez, Rosa Gonzalez-Polo, Jose Gonzalez-Reyes, Patricia González-Rodríguez, Ing Swie Goping, Marina Gorbatyuk, Nikolai Gorbunov, Kivanç Görgülü, Roxana Gorojod, Sharon Gorski, Sandro Goruppi, Cecilia Gotor, Roberta Gottlieb, Illana Gozes, Devrim Gozuacik, Martin Graef, Markus Gräler, Veronica Granatiero, Daniel Grasso, Joshua Gray, Douglas Green, Alexander Greenhough, Stephen Gregory, Edward Griffin, Mark Grinstaff, Frederic Gros, Charles Grose, Angelina Gross, Florian Gruber, Paolo Grumati, Tilman Grune, Xueyan Gu, Jun-Lin Guan, Carlos Guardia, Kishore Guda, Flora Guerra, Consuelo Guerri, Prasun Guha, Carlos Guillén, Shashi Gujar, Anna Gukovskaya, Ilya Gukovsky, Jan Gunst, Andreas Günther, Anyonya Guntur, Chuanyong Guo, Chun Guo, Hongqing Guo, Lian-Wang Guo, Ming Guo, Pawan Gupta, Shashi Kumar Gupta, Swapnil Gupta, Veer Bala Gupta, Vivek Gupta, Asa Gustafsson, David Gutterman, Ranjitha H.B., Annakaisa Haapasalo, James Haber, Aleksandra Hać, Shinji Hadano, Anders Hafrén, Mansour Haidar, Belinda Hall, Gunnel Halldén, Anne Hamacher-Brady, Andrea Hamann, Maho Hamasaki, Weidong Han, Malene Hansen, Phyllis I. Hanson, Zijian Hao, Masaru Harada, Ljubica Harhaji-Trajkovic, Nirmala Hariharan, Nigil Haroon, James Harris, Takafumi Hasegawa, Noor Hasima Nagoor, Jeffrey Haspel, Volker Haucke, Wayne Hawkins, Bruce Hay, Cole Haynes, Soren Hayrabedyan, Thomas Hays, Congcong He, Qin He, Rong-Rong He, You-Wen He, Yu-Ying He, Yasser Heakal, Alexander Heberle, J. Fielding Hejtmancik, Gudmundur Vignir Helgason, Vanessa Henkel, Marc Herb, Alexander Hergovich, Anna Herman-Antosiewicz, Agustín Hernández, Carlos Hernandez, Sergio Hernandez-Diaz, Virginia Hernandez-Gea, Amaury Herpin, Judit Herreros, Javier Hervás, Daniel Hesselson, Claudio Hetz, Volker Heussler, Yujiro Higuchi, Sabine Hilfiker, Joseph Hill, William Hlavacek, Emmanuel Ho, Idy H.T. Ho, Philip Wing-Lok Ho, Shu-Leong Ho, Wan Yun Ho, G. Aaron Hobbs, Mark Hochstrasser, Peter H.M. Hoet, Daniel Hofius, Paul Hofman, Annika Höhn, Carina Holmberg, Jose Hombrebueno, Chang-Won Hong, Yi-Ren Hong, Lora Hooper, Thorsten Hoppe, Rastislav Horos, Yujin Hoshida, I-Lun Hsin, Hsin-Yun Hsu, Bing Hu, Dong Hu, Li-Fang Hu, Ming Chang Hu, Ronggui Hu, Wei Hu, Yu-Chen Hu, Zhuo-Wei Hu, Fang Hua, Jinlian Hua, Yingqi Hua, Chongmin Huan, Canhua Huang, Chuanshu Huang, Chuanxin Huang, Chunling Huang, Haishan Huang, Kun Huang, Michael L.H. Huang, Rui Huang, Shan Huang, Tianzhi Huang, Xing Huang, Yuxiang Jack Huang, Tobias Huber, Virginie Hubert, Christian Hubner, Stephanie Hughes, William Hughes, Magali Humbert, Gerhard Hummer, James Hurley, Sabah Hussain, Salik Hussain, Patrick Hussey, Martina Hutabarat, Hui-Yun Hwang, Seungmin Hwang, Antonio Ieni, Fumiyo Ikeda, Yusuke Imagawa, Yuzuru Imai, Carol Imbriano, Masaya Imoto, Denise Inman, Ken Inoki, Juan Iovanna, Renato Iozzo, Giuseppe Ippolito, Javier Irazoqui, Pablo Iribarren, Mohd Ishaq, Makoto Ishikawa, Nestor Ishimwe, Ciro Isidoro, Nahed Ismail, Shohreh Issazadeh-Navikas, Eisuke Itakura, Daisuke Ito, Davor Ivankovic, Saška Ivanova, Anand Krishnan V. Iyer, José Izquierdo, Masanori Izumi, Marja Jäättelä, Majid Sakhi Jabir, William Jackson, Nadia Jacobo-Herrera, Anne-Claire Jacomin, Elise Jacquin, Pooja Jadiya, Hartmut Jaeschke, Chinnaswamy Jagannath, Arjen Jakobi, Johan Jakobsson, Bassam Janji, Pidder Jansen-Dürr, Patric Jansson, Jonathan Jantsch, Sławomir Januszewski, Alagie Jassey, Steve Jean, Hélène Jeltsch-David, Pavla Jendelova, Andreas Jenny, Thomas Jensen, Niels Jessen, Jenna Jewell, Jing Ji, Lijun Jia, Rui Jia, Liwen Jiang, Qing Jiang, Richeng Jiang, Teng Jiang, Xuejun Jiang, Yu Jiang, Maria Jimenez-Sanchez, Eun-Jung Jin, Fengyan Jin, Hongchuan Jin, Li Jin, Luqi Jin, Meiyan Jin, Si Jin, Eun-Kyeong Jo, Carine Joffre, Terje Johansen, Gail V.W. Johnson, Simon Johnston, Eija Jokitalo, Mohit Kumar Jolly, Leo A.B. Joosten, Joaquin Jordan, Bertrand Joseph, Dianwen Ju, Jeong-Sun Ju, Jingfang Ju, Esmeralda Juárez, Delphine Judith, Gábor Juhász, Youngsoo Jun, Chang Hwa Jung, Sung-Chul Jung, Yong Keun Jung, Heinz Jungbluth, Johannes Jungverdorben, Steffen Just, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Daniel Kaganovich, Alon Kahana, Renate Kain, Shinjo Kajimura, Maria Kalamvoki, Manjula Kalia, Danuta Kalinowski, Nina Kaludercic, Ioanna Kalvari, Joanna Kaminska, Vitaliy Kaminskyy, Hiromitsu Kanamori, Keizo Kanasaki, Chanhee Kang, Rui Kang, Sang Sun Kang, Senthilvelrajan Kaniyappan, Tomotake Kanki, Thirumala-Devi Kanneganti, Anumantha Kanthasamy, Arthi Kanthasamy, Marc Kantorow, Orsolya Kapuy, Michalis Karamouzis, Md. Razaul Karim, Parimal Karmakar, Rajesh Katare, Masaru Kato, Stefan H.E. 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2020
Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus
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Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases
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Cyclipostins and Cyclophostin Analogues as Multitarget Inhibitors That Impair Growth of Mycobacterium abscessus
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Worms’ Antimicrobial Peptides
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2019
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains
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Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria
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Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis
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Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases
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The potent effect of mycolactone on lipid membranes
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2018
Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages
Pierre Santucci, Sadia Diomandé, Isabelle Poncin, Laetitia Alibaud, Albertus Viljoen, Laurent Kremer, Chantal de Chastellier, Stéphane Canaan
Infection and Immunity 86 (2018)10.1128/IAI.00394-18
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LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling
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2018
Lipid Droplets Breakdown: Adipose Triglyceride Lipase Leads the Way
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2018
Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo
Albertus Viljoen, Matthias Richard, Phuong Chi Nguyen, Patrick Fourquet, Luc Camoin, Rishi R. Paudal, Giri R Gnawali, Christopher D Spilling, Jean-François Cavalier, Stéphane Canaan, Mickaël Blaise, Laurent Kremer
Journal of Biological Chemistry 293:2755-2769 (2018)10.1074/jbc.RA117.000760
2017
Efficient synthesis of novel dialkyl-3-cyanopropylphosphate derivatives and evaluation of their anticholinesterase activity
Iyadh Aouani, Badreddine Sellami, Karima Lahbib, Jean-François Cavalier, Soufiane Touil
Bioorganic Chemistry 72:301-307 (2017)10.1016/j.bioorg.2017.05.008
2016
A phospholipase A 1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery
Nicolas Flaugnatti, Thi Thu Hang Le, Stéphane Canaan, Marie-Stéphanie Aschtgen, Vân Nguyên, Stephanie Blangy, Christine Kellenberger, Alain Roussel, Christian Cambillau, E. Cascales, Laure Journet
Molecular Microbiology 99:1099-1118 (2016)10.1111/mmi.13292
2015
Biochemical characterization of Yarrowia lipolytica LIP8, a secreted lipase with a cleavable C-terminal region
Jannet Kamoun, Mathieu Schué, Wala Messaoud, Justine Baignol, Vanessa Point, Eduardo Mateos-Diaz, Pascal Mansuelle, Youssef Gargouri, Goetz Parsiegla, Jean-François Cavalier, Frédéric Carrière, Ahmed Aloulou
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1851:129-140 (2015)10.1016/j.bbalip.2014.10.012
2014
An interfacial and comparative in vitro study of gastrointestinal lipases and Yarrowia lipolytica LIP2 lipase, a candidate for enzyme replacement therapy
Anaïs Bénarouche, Vanessa Point, Frédéric Carrière, Jean-François Cavalier
Biochimie 102:145-153 (2014)10.1016/j.biochi.2014.03.004
2013
Solution conformational features and interfacial properties of an intrinsically disordered peptide coupled to alkyl chains: a new class of peptide amphiphiles
Antonella Accardo, Marilisa Leone, Diego Tesauro, Rosa Aufiero, Anaïs Bénarouche, Jean-François Cavalier, Sonia Longhi, Frederic Carriere, Filomena Rossi
Molecular BioSystems 9:1401 (2013)10.1039/c3mb25507g
2013
Biochemical and structural characterization of non-glycosylated Yarrowia lipolytica LIP2 lipase
Ahmed Aloulou, Anaïs Bénarouche, Delphine Puccinelli, Silvia Spinelli, Jean-François Cavalier, Christian Cambillau, Frédéric Carrière
European Journal of Lipid Science and Technology 115:429-441 (2013)10.1002/ejlt.201200440
2013
New insights into the pH-dependent interfacial adsorption of dog gastric lipase using the monolayer technique
Anaïs Bénarouche, Vanessa Point, Goetz Parsiegla, Frédéric Carrière, Jean-François Cavalier
Colloids and Surfaces B: Biointerfaces 111:306-312 (2013)10.1016/j.colsurfb.2013.06.025
2013
Effects of the propeptide of group X secreted phospholipase A2 on substrate specificity and interfacial activity on phospholipid monolayers
Vanessa Point, Anaïs Bénarouche, Ikram Jemel, Goetz Parsiegla, Gérard Lambeau, Frédéric Carrière, Jean-François Cavalier
Biochimie 95:51-58 (2013)10.1016/j.biochi.2012.07.023
2013
Enantioselective Inhibition of Microbial Lipolytic Enzymes by Nonracemic Monocyclic Enolphosphonate Analogues of Cyclophostin
Vanessa Point, Raj Malla, Frederic Carrière, Stéphane Canaan, Christopher Spilling, Jean-François Cavalier
Journal of Medicinal Chemistry 56:4393-4401 (2013)10.1021/jm4000787
2012
Synthesis and Kinetic Evaluation of Cyclophostin and Cyclipostins Phosphonate Analogs As Selective and Potent Inhibitors of Microbial Lipases
Vanessa Point, Raj Malla, Sadia Diomande, Benjamin Martin, Vincent Delorme, Frederic Carriere, Stephane Canaan, Nigam Rath, Christopher Spilling, Jean-François Cavalier
Journal of Medicinal Chemistry 55:10204-10219 (2012)10.1021/jm301216x
2009
Synthesis, Structure-activity Relationship and In Vitro Evaluation of Coelenterazine and Coelenteramine Derivatives as Inhibitors of Lipid Peroxidation
Maggi Burton, Catherine de Tollenaere, Jean-François Cavalier, Cécile Marchand, Frédérique Dussart, Jacqueline Marchand-Brynaert, Jean-François Rees
Free Radical Research 37:145-158 (2009)10.1080/1071576021000036443
2005
Discrimination between closed and open forms of lipases using electrophoretic techniques
Jean-François Cavalier, N. Miled, M. Riviere, J.F. Cavalier, G. Buono, L. Berti, R. Verger
Analytical Biochemistry 338:171-178 (2005)10.1016/j.ab.2004.11.046
2004
2,6-Diamino-3,5-diaryl-1,4-pyrazine Derivatives as Novel Antioxidants
Jean-François Cavalier, Maggi Burton, Catherine de Tollenaere, Frédérique Dussart, Cécile Marchand, Jean-François Rees, Jacqueline Marchand-Brynaert
Synthesis: Journal of Synthetic Organic Chemistry 2001:0768-0772 (2004)10.1055/s-2001-12764
2003
N -(Alkyl)-2-amino-1,4-pyrazine Derivatives: Synthesis and Antioxidative Properties of 3- and 3,5- p -Hydroxyphenyl-Substituted Compounds
Paul Jeanjot, Frédéric Bruyneel, Axelle Arrault, Sonia Gharbi, Jean-François Cavalier, Agnès Abels, Cécile Marchand, Roland Touillaux, Jean-François Rees, Jacqueline Marchand-Brynaert
Synthesis: Journal of Synthetic Organic Chemistry 2003:0513-0522 (2003)10.1055/s-2003-37652
2001
Catechol derivatives of aminopyrazine and cell protection against uvb-induced mortality
Jean-François Cavalier, Maggi Burton, Frédérique Dussart, Cécile Marchand, Jean-François Rees, Jacqueline Marchand-Brynaert
Bioorganic & Medicinal Chemistry Letters 9:1037-1044 (2001)10.1016/s0968-0896(00)00321-7
2000
2000
Covalent Inhibition of Digestive Lipases by Chiral Phosphonates
Jean-François Cavalier, Gerard Buono, Robert Verger
Accounts of Chemical Research 33:579-589 (2000)10.1021/ar990150i
1999
Inhibition of human gastric and pancreatic lipases by chiral alkylphosphonates. A kinetic study with 1,2-didecanoyl-sn-glycerol monolayer
Jean-François Cavalier, Stéphane Ransac, Robert Verger, Gérard Buono
Chemistry and Physics of Lipids 100:3-31 (1999)10.1016/s0009-3084(99)00028-6
1999
Interfacial and/or molecular recognition by lipases of mixed monomolecular films of 1,2-dicaprin and chiral organophosphorus glyceride analogues?
Frank Marguet, Isabelle Douchet, Jean-François Cavalier, Gerard Buono, Robert Verger
Colloids and Surfaces B: Biointerfaces 13:37-45 (1999)10.1016/S0927-7765(98)00099-X
1999
New Synthesis of sn-1,2-and sn-2,3-O-Diacylglycerols ؊ Application to the Synthesis of Enantiopure Phosphonates Analogous to Triglycerides: A New Class of Inhibitors of Lipases
Frank Marguet, Jean-François Cavalier, Robert Verger, Gérard Buono
European Journal of Organic Chemistry (1999)
1998
New Highly Diastereoselective Synthesis of Phosphoramidates. A Route to Chiral Methyl p -Nitrophenyl Alkylphosphonates
Jean-François Cavalier, Frédéric Fotiadu, Robert Verger, Gérard Buono
SYNLETT 1998:73-75 (1998)10.1055/s-1998-1560
Collaborations
- National
- J.-L. Hermann APHP Paris
- L. Kremer Irim Montpellier
- L. Marsollier Inserm Angers
- International
- V. Magrioti University of Athens, Greece
- C. D. Spilling University of Missouri, St Louis, USA
Funding
